TOPORS and MTDH

Number of citations of the paper that reports this interaction (PMID 24529480)
0

Data Source:
BioGRID (pull down)

		TOPORS	MTDH
Gene Name		topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	metadherin
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Spindle Pole Gamma-tubulin Complex Nucleus Centriole Cytoplasmic Dynein Complex PML Body Nuclear Speck Midbody Photoreceptor Connecting Cilium Ciliary Basal Body	Nucleus Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Tight Junction Integral Component Of Membrane Apical Plasma Membrane Nuclear Body Nuclear Membrane Intercellular Canaliculus Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Antigen Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity SUMO Transferase Activity DNA Topoisomerase Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Transcription Factor Binding Transcription Coactivator Activity Double-stranded RNA Binding Protein Binding Poly(A) RNA Binding NF-kappaB Binding
	Biological Process	Transcription, DNA-templated Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Cellular Response To DNA Damage Stimulus Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Retina Layer Formation Protein Sumoylation Protein Localization To Nucleus Photoreceptor Cell Outer Segment Organization Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Retinal Rod Cell Development Retinal Cone Cell Development Positive Regulation Of Ubiquitin-protein Transferase Activity Maintenance Of Protein Location In Nucleus Protein K48-linked Ubiquitination	Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Autophagy Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Angiogenesis Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Tight Junction Assembly
Pathways
Drugs
Diseases
GWAS		Immune response to smallpox vaccine (IL-6) ( 22610502)	Migraine ( 20802479)
Protein-Protein Interactions		24 interactors: CASP8 H2AFX HABP4 MTDH NKX3-1 SATB1 SERBP1 SIN3A SNIP1 SUMO1 SUMO2 TOP1 TP53 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2J1 UBE2L6 UBE2N UBE2W	2 interactors: CSNK2A1 TOPORS
Entrez ID		10210	92140
HPRD ID		11642	17459
Ensembl ID		ENSG00000197579	ENSG00000147649
Uniprot IDs		Q9NS56	Q86UE4
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Polyubiquitination Protein Catabolic Process Modification-dependent Protein Catabolic Process Regulation Of Innate Immune Response Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Cellular Macromolecule Catabolic Process Cellular Response To Organic Substance Protein K48-linked Ubiquitination Positive Regulation Of Innate Immune Response Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Ubiquitin-dependent Protein Catabolic Process Toll-like Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Response To Oxygen Levels Regulation Of DNA-templated Transcription In Response To Stress Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Proteolysis Response To Organic Substance Negative Regulation Of Gene Expression Cellular Protein Modification Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Response To Stress Proteolysis Regulation Of Metabolic Process Cellular Protein Metabolic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Response To Hypoxia Positive Regulation Of Cellular Protein Catabolic Process Catabolic Process DNA Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process	Photoreceptor Cell Outer Segment Organization Retinal Cone Cell Development Retinal Rod Cell Development Camera-type Eye Photoreceptor Cell Differentiation Maintenance Of Protein Location In Nucleus Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Neuron Development Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Death Protein Sumoylation Retina Layer Formation Neuron Differentiation Cell Projection Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Protein Metabolic Process Protein K48-linked Ubiquitination Eye Photoreceptor Cell Development Mitotic Spindle Checkpoint Negative Regulation Of Chromosome Segregation Protein Monoubiquitination Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Photoreceptor Cell Development Regulation Of Cell Proliferation Spindle Checkpoint Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Mitotic Nuclear Division Eye Photoreceptor Cell Differentiation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Cell Death Generation Of Neurons Neural Retina Development Retina Morphogenesis In Camera-type Eye Neurogenesis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Chaperone-mediated Protein Folding Negative Regulation Of Proteasomal Protein Catabolic Process Cell Development Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cellular Protein Catabolic Process Positive Regulation Of Ligase Activity Negative Regulation Of Cell Division Regulation Of Chromosome Segregation Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity
Tagcloud ?		bindingprotein blockade condition deprivation diphosphate e3 eliminates ern1 finction finger glioma glutamine matrin nm23 nme nme6 nucleoside ofrybpi oftumor regulatedpa26 rybp sesn1 tp53 tp53bp1 tp53bpi tp53tg1 u87 zmat3	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Difference) ?		bindingprotein blockade condition deprivation diphosphate e3 eliminates ern1 finction finger glioma glutamine matrin nm23 nme nme6 nucleoside ofrybpi oftumor regulatedpa26 rybp sesn1 tp53 tp53bp1 tp53bpi tp53tg1 u87 zmat3	aldh1a1 anxa1 bcar1 cldn1 crmp1 endpoint folr1 foxm1 il12rb2 il7r inconclusive kiaa1524 lox mcm7 mta1 ncoa3 ndrg2 nedd9 nes overview pbk ppm1d principally prognostication qualifying slc7a5 sqstm1 warranted wnt1
Tagcloud (Intersection) ?