CPNE2 and UBE2M

Number of citations of the paper that reports this interaction (PMID 12522145)
20

Data Source:
HPRD (two hybrid)

		CPNE2	UBE2M
Gene Name		copine II	ubiquitin-conjugating enzyme E2M
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Vesicular Exosome	Cytoplasm Cytosol Extracellular Vesicular Exosome
	Molecular Function		Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ribosomal S6-glutamic Acid Ligase Activity NEDD8 Transferase Activity Ubiquitin Protein Ligase Binding Ubiquitin Protein Ligase Activity
	Biological Process		Cellular Protein Modification Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Neuron Apoptotic Process Protein Neddylation
Pathways			Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer SMAD2/3 Phosphorylation Motif Mutants in Cancer Antigen processing: Ubiquitination & Proteasome degradation Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex Signaling by TGF-beta Receptor Complex in Cancer Class I MHC mediated antigen processing & presentation SMAD4 MH2 Domain Mutants in Cancer Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		18 interactors: ACTB ANXA7 BCOR CDKN1A IKBKG LNX1 MYCBP PDCD6 PPP5C RDX REL SKIL SORBS3 TERF2IP TRIM27 UBA3 UBE2M UBE2O	24 interactors: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL3 CUL7 DCUN1D3 DCUN1D4 MARCH7 MDM2 NAE1 NEDD4 NEDD8 PARK2 PINK1 RBX1 RNF111 RNF7 TP53 UBA3 UBC
Entrez ID		221184	9040
HPRD ID		05015	04414
Ensembl ID		ENSG00000140848	ENSG00000130725
Uniprot IDs		Q96FN4	P61081
PDB IDs			1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO
Enriched GO Terms of Interacting Partners?		Protein Modification By Small Protein Conjugation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Protein Neddylation Positive Regulation Of Signal Transduction Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Regulation Of Cellular Component Organization Protein Ubiquitination Regulation Of Cellular Process Transcription, DNA-templated Regulation Of Intracellular Signal Transduction RNA Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Protein Oligomerization Protein K63-linked Ubiquitination Protein Trimerization Response To Stress NIK/NF-kappaB Signaling Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Organelle Organization Protein Monoubiquitination Regulation Of Signal Transduction Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Epithelial Cell Differentiation Regulation Of Cell Death Negative Regulation Of Histone H3-K36 Methylation Negative Regulation Of DNA Recombination At Telomere Positive Regulation Of Programmed Cell Death I-kappaB Kinase/NF-kappaB Signaling Regulation Of Signaling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Death Fc Receptor Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Cellular Response To Heat Lymphocyte Homeostasis Retrograde Transport, Endosome To Golgi Negative Regulation Of RNA Biosynthetic Process RNA Metabolic Process Regulation Of Neuron Death Cellular Protein Modification Process Negative Regulation Of Tooth Mineralization Negative Regulation Of Interleukin-2 Secretion Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Neddylation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Cellular Protein Modification Process Protein Catabolic Process Cellular Macromolecule Catabolic Process Cellular Protein Metabolic Process Protein Monoubiquitination Proteolysis Positive Regulation Of Protein Metabolic Process Positive Regulation Of Proteolysis Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Hypoxia Regulation Of Mitochondrion Degradation Cellular Response To Decreased Oxygen Levels Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Regulation Of Cell Cycle Phase Transition Cellular Response To Oxygen Levels Regulation Of Mitotic Cell Cycle Regulation Of Cell Cycle Positive Regulation Of Protein Ubiquitination Catabolic Process Notch Signaling Pathway Regulation Of Cell Cycle Process Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Mitotic Cell Cycle Negative Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Catabolic Process Viral Process Protein Polyubiquitination Negative Regulation Of Signaling Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Regulation Of Protein Catabolic Process Apoptotic Process Cellular Response To Toxic Substance Regulation Of Proteolysis Positive Regulation Of Cell Cycle Process Signaling Mitotic Cell Cycle Process Response To Oxidative Stress
Tagcloud ?			acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Difference) ?			acts affects balance brca1 breaks choice controller controlling ctip cytotoxic deneddylation great homologous indeed neddylation nhej recombination repair repaired resection respond rnf111 ssdna strand subpathways tight toward uncover way
Tagcloud (Intersection) ?