CPNE2 and UBA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CPNE2	UBA3
Description		copine 2	ubiquitin like modifier activating enzyme 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	Nucleotide Binding Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity NEDD8 Activating Enzyme Activity NEDD8 Transferase Activity Identical Protein Binding Protein Heterodimerization Activity
	Biological Process	Cellular Response To Calcium Ion	Mitotic Cell Cycle Proteolysis Endomitotic Cell Cycle Protein Modification Process Post-translational Protein Modification Protein Neddylation Regulation Of Cell Cycle
Pathways			Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Meat-related diet ( 32066663)
Interacting Genes		28 interacting genes: ACTB ANXA7 BCOR CDKN1A CT55 EFHC2 GBP7 IKBKG KATNBL1 LNX1 MEI4 MEOX2 MYCBP NCKIPSD PDCD6 PICK1 PPP5C RDX REL SKIL SORBS3 TCF4 TERF2IP THAP4 TRIM27 UBA3 UBE2M UBE2O	16 interacting genes: CHD3 CPNE2 CUL5 DSCAM DUSP23 IMPA2 KDM1A NAE1 NEDD8 OGT RNF7 TRIM55 TRIM63 UBE2D2 UBE2F UBE2M
Entrez ID		221184	9039
HPRD ID		05015	04413
Ensembl ID		ENSG00000140848	ENSG00000144744
Uniprot IDs		Q96FN4	F8W8D4 Q8TBC4
PDB IDs			1R4M 1R4N 1TT5 1Y8X 1YOV 2LQ7 2NVU 3DBH 3DBL 3DBR 3FN1 3GZN 5JJM
Enriched GO Terms of Interacting Partners?		Cytoplasm Nucleus Identical Protein Binding Negative Regulation Of Type I Interferon Production Ubiquitin-protein Transferase Activity NEDD8 Transferase Activity Nucleoplasm Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cellular Component Organization Apical Protein Localization Arp2/3 Complex Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Domain Specific Binding Protein Neddylation	Protein Neddylation Protein Modification By Small Protein Conjugation NEDD8 Transferase Activity Protein Modification Process Post-translational Protein Modification Regulation Of Cell Junction Assembly NEDD8 Conjugating Enzyme Activity Negative Regulation Of Focal Adhesion Disassembly NEDD8 Ligase Activity Protein Metabolic Process Regulation Of Postsynapse Assembly Protein Ubiquitination Regulation Of Synapse Assembly Erythropoietin-mediated Signaling Pathway Negative Regulation Of Growth Hormone Receptor Signaling Pathway Regulation Of Growth Hormone Receptor Signaling Pathway Reelin-mediated Signaling Pathway Epithelial To Mesenchymal Transition Ubiquitin-protein Transferase Activity Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cul5-RING Ubiquitin Ligase Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein Polyubiquitination Layer Formation In Cerebral Cortex Mesenchymal Cell Differentiation Negative Regulation Of Focal Adhesion Assembly Regulation Of Synapse Organization Innate Immune Response Growth Hormone Receptor Signaling Pathway Ubiquitin Protein Ligase Activity Regulation Of Postsynapse Organization Proteolysis Involved In Protein Catabolic Process CGAS/STING Signaling Pathway Positive Regulation Of Focal Adhesion Assembly Nucleus Defense Response To Symbiont Proteolysis Transferase Activity Defense Response To Other Organism Negative Regulation Of Cell-matrix Adhesion Protein K11-linked Ubiquitination Regulation Of Cellular Component Organization Macromolecule Metabolic Process Regulation Of Neuron Migration Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Defense Response Regulation Of Glycolytic Process
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