CPNE2 and THAP4

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CPNE2	THAP4
Description		copine 2	THAP domain containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Calcium-dependent Phospholipid Binding Metal Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Isomerase Activity Heme Binding Identical Protein Binding Metal Ion Binding Peroxynitrite Isomerase Activity Nitric Oxide Binding
	Biological Process	Cellular Response To Calcium Ion	Tyrosine Metabolic Process Nitrate Metabolic Process
Pathways
Drugs
Diseases
GWAS			Brain structure ( 20171287) Femur bone mineral density x serum urate levels interaction ( 34046847) Hip circumference adjusted for BMI ( 34021172) Platelet count ( 32888494) Prostate cancer ( 23535732) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		28 interacting genes: ACTB ANXA7 BCOR CDKN1A CT55 EFHC2 GBP7 IKBKG KATNBL1 LNX1 MEI4 MEOX2 MYCBP NCKIPSD PDCD6 PICK1 PPP5C RDX REL SKIL SORBS3 TCF4 TERF2IP THAP4 TRIM27 UBA3 UBE2M UBE2O	43 interacting genes: AGTRAP AIG1 AMD1 ANKRD46 APP BSND CACNG1 CD81 CLCA4 CMTM5 CMTM7 COL4A5 CPNE2 CTSA CYP4F2 DGAT2L6 FKBP7 GIMAP1 GPR37L1 IGFBP5 LAT LCOR LPAR3 MAL2 MAPK6 MOB4 MS4A1 NDRG4 PLP2 RMDN2 RTP2 SCAMP1 SLC30A8 SYP TMEM107 TMEM60 TMEM86A TMEM86B TNFRSF10D TPD52 TRIM54 TTPA YIPF6
Entrez ID		221184	51078
HPRD ID		05015	11630
Ensembl ID		ENSG00000140848	ENSG00000176946
Uniprot IDs		Q96FN4	Q8WY91
PDB IDs			3IA8
Enriched GO Terms of Interacting Partners?		Cytoplasm Nucleus Identical Protein Binding Negative Regulation Of Type I Interferon Production Ubiquitin-protein Transferase Activity NEDD8 Transferase Activity Nucleoplasm Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cellular Component Organization Apical Protein Localization Arp2/3 Complex Binding Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein Domain Specific Binding Protein Neddylation	Membrane Alkenylglycerophosphocholine Hydrolase Activity Vitamin E Metabolic Process
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