PTPRU and IRS1

  • Number of citations of the paper that reports this interaction (PMID 11781100)
  • 6
  • Data Source:
  • BioGRID (enzymatic study)

PTPRU

IRS1

Gene Name protein tyrosine phosphatase, receptor type, U insulin receptor substrate 1
Image No pdb structure
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Bipolar disorder and schizophrenia ( 20889312)
  • Non-alcoholic fatty liver disease ( 23535911)
  • Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions 8 interactors: CTNNB1 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT PPFIA3 73 interactors: AKT1 ALK AP3S1 APP ATP2A1 ATP2A2 ATP2A3 BCL2L1 BCR CAV1 CDH1 CHUK CRK CSNK2A1 CSNK2B EGFR ERBB2 FBXO25 FBXW8 FER FES FYN GHR GRB10 GRB14 GRB2 IGF1R IKBKB IL4R INSR JAK1 JAK2 JAK3 MAPK1 MAPK8 MAPK9 MTOR NCK2 NEDD4 NPM1 NTRK1 PDPK1 PHIP PIK3R1 PIK3R2 PIK3R3 PLCG2 PRKCD PRKCG PRKCQ PRKCZ PTK2 PTPN1 PTPN11 PTPRC PTPRF PTPRU RAD51 ROCK1 RPS6KB1 RPTOR SH2B1 SHC1 SIK2 SOCS1 SOCS3 TUB TYK2 UBTF YWHAB YWHAE YWHAG YWHAZ
Entrez ID 10076 3667
HPRD ID 03908 00943
Ensembl ID ENSG00000060656 ENSG00000169047
Uniprot IDs Q92729 P35568
PDB IDs 1IRS 1K3A 1QQG 2Z8C
Enriched GO Terms of Interacting Partners?
Tagcloud ?
adhesion  adjacent  attenuation  catenin  colon  delivered  dephosphorylating  find  focal  fragment  full  gastric  isoform  kda  knockdown  lentivirus  localized  lowly  lysine  phosphatase  reducing  relatively  respective  serve  shrna  suppressor  tissues  tyrosine 
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kda  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  tyrosine  wortmannin 
Tagcloud (Difference) ?
adhesion  adjacent  attenuation  catenin  colon  delivered  dephosphorylating  find  focal  fragment  full  gastric  isoform  knockdown  lentivirus  localized  lowly  lysine  phosphatase  reducing  relatively  respective  serve  shrna  suppressor  tissues 
action  adipocytes  biochem  biophys  coimmunoprecipitation  coincided  commun  docking  evidenced  extent  gh  initiating  insulin  involvement  kinase  phosphatidylinositol  phosphorylated  pi  postreceptor  res  ridderstrale  seems  substrate  thereby  tornqvist  wortmannin 
Tagcloud (Intersection) ?
kda  tyrosine