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PTPRU
Gene Name
protein tyrosine phosphatase, receptor type, U
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Molecular Function
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
Beta-catenin Binding
Biological Process
Protein Dephosphorylation
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway
Negative Regulation Of Cell Proliferation
Single Organismal Cell-cell Adhesion
Cell Differentiation
Negative Regulation Of Cell Migration
Organ Regeneration
Homotypic Cell-cell Adhesion
Protein Localization To Cell Surface
Peptidyl-tyrosine Dephosphorylation
Response To Glucocorticoid
Canonical Wnt Signaling Pathway
Pathways
Signaling by SCF-KIT
Drugs
Diseases
GWAS
Bipolar disorder and schizophrenia (
20889312
)
Non-alcoholic fatty liver disease (
23535911
)
Prostate cancer (gene x gene interaction) (
22219177
)
Protein-protein Interactions
8 interactors:
CTNNB1
GNAI1
GNAI2
GNAI3
GNAO1
IRS1
KIT
PPFIA3
Entrez ID
10076
HPRD ID
03908
Ensembl ID
ENSG00000060656
Uniprot IDs
Q92729
PDB IDs
Enriched GO Terms of Interacting Partners
?
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Synaptic Transmission
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cell Activation
Cell-cell Signaling
Cell Surface Receptor Signaling Pathway
Cell Division
Response To Stress
Signaling
Cell Communication
Negative Regulation Of Adenylate Cyclase Activity
Negative Regulation Of Lyase Activity
Regulation Of Calcium Ion Transport
Platelet Activation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of CAMP Biosynthetic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of CAMP Metabolic Process
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of Nucleotide Metabolic Process
Positive Regulation Of Cell Proliferation
Response To Organonitrogen Compound
Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Phosphorylation
Regulation Of Synaptic Transmission
Regulation Of Phosphatidylinositol 3-kinase Activity
Vesicle Fusion
Response To Hormone
Regulation Of Adenylate Cyclase Activity
Regulation Of Neuronal Synaptic Plasticity
Signal Transduction
Regulation Of Lipid Kinase Activity
Regulation Of Cyclase Activity
Positive Regulation Of Stem Cell Proliferation
Organelle Fusion
Blood Coagulation
Hemostasis
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Mast Cell Cytokine Production
Melanocyte Adhesion
Dendritic Cell Cytokine Production
Mast Cell Proliferation
Response To Peptide Hormone
Regulation Of CAMP Biosynthetic Process
Response To Peptide
Regulation Of Catalytic Activity
Positive Regulation Of Kinase Activity
Positive Regulation Of Signal Transduction
Tagcloud
?
adhesion
adjacent
attenuation
catenin
colon
delivered
dephosphorylating
find
focal
fragment
full
gastric
isoform
kda
knockdown
lentivirus
localized
lowly
lysine
phosphatase
reducing
relatively
respective
serve
shrna
suppressor
tissues
tyrosine