PTPRU and GNAO1

Number of citations of the paper that reports this interaction (PMID 10196137)
13

Data Source:
HPRD (in vitro, in vivo)

		PTPRU	GNAO1
Gene Name		protein tyrosine phosphatase, receptor type, U	guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction	Heterotrimeric G-protein Complex Plasma Membrane Neuron Projection
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding	GTPase Activity Signal Transducer Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G-protein Coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding GTPase Activating Protein Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Organ Regeneration Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Response To Glucocorticoid Canonical Wnt Signaling Pathway	Muscle Contraction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Aging Locomotory Behavior Regulation Of Heart Contraction Forebrain Development Neuron Projection Development Response To Cytokine Response To Drug Response To Hydrogen Peroxide Response To Morphine Positive Regulation Of GTPase Activity Negative Regulation Of Calcium Ion Transport
Pathways		Signaling by SCF-KIT	Signaling by GPCR Ca2+ pathway PLC beta mediated events G-protein activation Opioid Signalling Signaling by Wnt G-protein mediated events beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312) Non-alcoholic fatty liver disease ( 23535911) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		8 interactors: CTNNB1 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT PPFIA3	34 interactors: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		10076	2775
HPRD ID		03908	00757
Ensembl ID		ENSG00000060656	ENSG00000087258
Uniprot IDs		Q92729	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell Activation Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Division Response To Stress Signaling Cell Communication Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of CAMP Biosynthetic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Synaptic Transmission Regulation Of Phosphatidylinositol 3-kinase Activity Vesicle Fusion Response To Hormone Regulation Of Adenylate Cyclase Activity Regulation Of Neuronal Synaptic Plasticity Signal Transduction Regulation Of Lipid Kinase Activity Regulation Of Cyclase Activity Positive Regulation Of Stem Cell Proliferation Organelle Fusion Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Response To Peptide Hormone Regulation Of CAMP Biosynthetic Process Response To Peptide Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Positive Regulation Of ERBB Signaling Pathway Signaling Cell Communication Signal Transduction Cell-cell Signaling Neurological System Process Regulation Of Signal Transduction Locomotory Behavior Positive Regulation Of GTPase Activity Negative Regulation Of Epinephrine Secretion Regulation Of Sensory Perception Of Pain Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of GTPase Activity Positive Regulation Of Metabolic Process Behavior Regulation Of ERBB Signaling Pathway Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Response To Stimulus Regulation Of Phosphorus Metabolic Process Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Cellular Response To Stimulus Regulation Of Cellular Process Positive Regulation Of Hydrolase Activity Sensory Perception Regulation Of Neurological System Process Regulation Of Adenylate Cyclase Activity Negative Regulation Of Smooth Muscle Contraction Regulation Of Ion Transport Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Hormone Secretion Negative Regulation Of Uterine Smooth Muscle Contraction Regulation Of Cyclase Activity Single-organism Behavior Regulation Of MAP Kinase Activity Negative Regulation Of Secretion By Cell
Tagcloud ?		adhesion adjacent attenuation catenin colon delivered dephosphorylating find focal fragment full gastric isoform kda knockdown lentivirus localized lowly lysine phosphatase reducing relatively respective serve shrna suppressor tissues tyrosine	aberrations assessing associations catenin clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?		adhesion adjacent attenuation colon delivered dephosphorylating find focal fragment full gastric isoform kda knockdown lentivirus localized lowly lysine phosphatase reducing relatively respective serve shrna suppressor tissues tyrosine	aberrations assessing associations clinicopathological egfr gnai2 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?		catenin