PTPRU and OMG

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		PTPRU	OMG
Description		protein tyrosine phosphatase receptor type U	oligodendrocyte myelin glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Anchoring Junction	Plasma Membrane Membrane Side Of Membrane
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Differentiation Negative Regulation Of Cell Migration Animal Organ Regeneration Neuron Projection Development Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Cell Adhesion Neuron Projection Regeneration
Pathways		Signaling by SCF-KIT	Axonal growth inhibition (RHOA activation)
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Bipolar disorder and schizophrenia ( 20889312) Blood protein levels ( 30072576) Carotid plaque maximum area ( 32469969) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Mean area of carotid plaque ( 32469969) Mean corpuscular volume ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Schizophrenia ( 28991256) Tourette syndrome ( 30818990)	Brain morphology (MOSTest) ( 32665545) Diverticular disease ( 30177863) Oily fish consumption ( 32066663) Pork consumption ( 32066663)
Interacting Genes		12 interacting genes: CTNNB1 EGFR ERBB2 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT OMG OSTN PPFIA3	6 interacting genes: PTPRD PTPRF PTPRS PTPRU RTN4R RTN4RL1
Entrez ID		10076	4974
HPRD ID		03908	01257
Ensembl ID		ENSG00000060656	ENSG00000126861
Uniprot IDs		Q92729	P23515
PDB IDs		6SUB 6SUC
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Ciliary Basal Body Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell Adenylate Cyclase Regulator Activity Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion Transmembrane Receptor Protein Tyrosine Kinase Activity Midbody Negative Regulation Of Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB Signaling Pathway Plasma Membrane Basolateral Plasma Membrane Cell Surface Receptor Signaling Pathway Negative Regulation Of Hormone Secretion G Protein-coupled Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Protein Secretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Presynaptic Active Zone Cytoplasmic Component Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding GTPase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Transport Nucleotide Binding Protein Tyrosine Kinase Activity G Protein-coupled Serotonin Receptor Signaling Pathway Signal Transduction GTP Binding Cell Population Proliferation Presynaptic Membrane ERBB2 Signaling Pathway Negative Regulation Of Establishment Of Protein Localization Signaling Receptor Binding Regulation Of Cell Communication	Regulation Of Neuron Projection Regeneration Regulation Of Axon Regeneration Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Chondroitin Sulfate Binding Negative Regulation Of Axon Regeneration Negative Regulation Of Neuron Projection Regeneration Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Tyrosine Phosphatase Activity Corpus Callosum Development Synaptic Membrane Adhesion Phosphoprotein Phosphatase Activity Regulation Of Neuron Projection Development Heparin Binding Regulation Of Synapse Assembly Regulation Of Response To Wounding Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Junction Assembly Regulation Of Cell Projection Organization Regulation Of Synapse Organization Protein Dephosphorylation Negative Regulation Of Neuron Projection Development Regulation Of Nervous System Development Regeneration Dephosphorylation Regulation Of Postsynaptic Density Assembly Regulation Of Postsynapse Organization Perikaryon Cell-cell Adhesion Regulation Of Postsynaptic Specialization Assembly Regulation Of Excitatory Synapse Assembly Regulation Of Cellular Response To Stress Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Projection Organization Neuron Projection Regeneration Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Negative Regulation Of Axon Extension Developmental Process Cell Adhesion Regulation Of Dendritic Spine Development Negative Regulation Of Axonogenesis Positive Regulation Of Synapse Assembly Neuron Projection Regulation Of Neurogenesis Chondroitin Sulfate Proteoglycan Binding Extracellular Exosome Regulation Of Axon Extension Cell Projection Organization Cell Adhesion Molecule Binding Negative Regulation Of Developmental Growth Schaffer Collateral - CA1 Synapse
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