PTPRU and GNAI2

Number of citations of the paper that reports this interaction (PMID 16298104)
9

Data Source:
HPRD (in vitro, in vivo)

		PTPRU	GNAI2
Gene Name		protein tyrosine phosphatase, receptor type, U	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Midbody Vesicle Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding	G-protein Coupled Receptor Binding GTPase Activity Signal Transducer Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Proliferation Single Organismal Cell-cell Adhesion Cell Differentiation Negative Regulation Of Cell Migration Organ Regeneration Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Response To Glucocorticoid Canonical Wnt Signaling Pathway	Activation Of MAPKK Activity Adenosine Receptor Signaling Pathway Cell Cycle Signal Transduction G-protein Coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G-protein Coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission Response To Nutrient Blood Coagulation Cell Proliferation Positive Regulation Of Cell Proliferation Platelet Activation Intracellular Signal Transduction Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport
Pathways		Signaling by SCF-KIT	Signaling by GPCR Integration of energy metabolism G alpha (s) signalling events Activation of GABAB receptors Signal amplification G alpha (z) signalling events G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell ADP signalling through P2Y purinoceptor 12 GABA B receptor activation Adenylate cyclase inhibitory pathway GABA receptor activation PLC beta mediated events Opioid Signalling Regulation of insulin secretion G-protein mediated events Adrenaline,noradrenaline inhibits insulin secretion Inhibition of adenylate cyclase pathway Adenylate cyclase inhibitory pathway GPCR downstream signaling G-protein activation Platelet activation, signaling and aggregation Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Bipolar disorder and schizophrenia ( 20889312) Non-alcoholic fatty liver disease ( 23535911) Prostate cancer (gene x gene interaction) ( 22219177)
Protein-Protein Interactions		8 interactors: CTNNB1 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT PPFIA3	64 interactors: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR ESR1 EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MCF2 MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NL NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A
Entrez ID		10076	2771
HPRD ID		03908	00764
Ensembl ID		ENSG00000060656	ENSG00000114353
Uniprot IDs		Q92729	B3KP24 B3KX51 P04899
PDB IDs
Enriched GO Terms of Interacting Partners?		Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Synaptic Transmission Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Cell Activation Cell-cell Signaling Cell Surface Receptor Signaling Pathway Cell Division Response To Stress Signaling Cell Communication Negative Regulation Of Adenylate Cyclase Activity Negative Regulation Of Lyase Activity Regulation Of Calcium Ion Transport Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of CAMP Biosynthetic Process Regulation Of Phosphorus Metabolic Process Negative Regulation Of CAMP Metabolic Process Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Phosphorylation Regulation Of Synaptic Transmission Regulation Of Phosphatidylinositol 3-kinase Activity Vesicle Fusion Response To Hormone Regulation Of Adenylate Cyclase Activity Regulation Of Neuronal Synaptic Plasticity Signal Transduction Regulation Of Lipid Kinase Activity Regulation Of Cyclase Activity Positive Regulation Of Stem Cell Proliferation Organelle Fusion Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Mast Cell Cytokine Production Melanocyte Adhesion Dendritic Cell Cytokine Production Mast Cell Proliferation Response To Peptide Hormone Regulation Of CAMP Biosynthetic Process Response To Peptide Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity Positive Regulation Of Signal Transduction	G-protein Coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Signal Transduction G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Signaling Cell Communication Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of Catalytic Activity Cellular Response To Stimulus Positive Regulation Of Catalytic Activity Response To Stimulus Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signaling Regulation Of Signal Transduction Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Hydrolase Activity Negative Regulation Of Signaling Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Negative Regulation Of Signal Transduction Inflammatory Response Regulation Of Protein Kinase Activity Regulation Of Cellular Process Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cytosolic Calcium Ion Homeostasis Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Phosphorylation Termination Of G-protein Coupled Receptor Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of MAPK Cascade Termination Of Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Intracellular Signal Transduction Response To Organic Substance Positive Regulation Of Signal Transduction Positive Regulation Of Protein Phosphorylation Chemical Homeostasis Intracellular Signal Transduction Regulation Of Metabolic Process Regulation Of Smooth Muscle Contraction Response To Stress Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Metal Ion Homeostasis Cellular Calcium Ion Homeostasis Positive Regulation Of Kinase Activity
Tagcloud ?		adhesion adjacent attenuation catenin colon delivered dephosphorylating find focal fragment full gastric isoform kda knockdown lentivirus localized lowly lysine phosphatase reducing relatively respective serve shrna suppressor tissues tyrosine	aberrations assessing associations catenin clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Difference) ?		adhesion adjacent attenuation colon delivered dephosphorylating find focal fragment full gastric isoform kda knockdown lentivirus localized lowly lysine phosphatase reducing relatively respective serve shrna suppressor tissues tyrosine	aberrations assessing associations clinicopathological egfr gnao1 gnaq gnas grades impacts intraductal ipmn ipmns kras morphological mucinous mutations neoplasm overexpression pakt pancreas papillary phenotypes pik3ca pmapk retrospectively smad4 tp53
Tagcloud (Intersection) ?		catenin