PTPRU and OSTN

Number of citations of the paper that reports this interaction (PubMedID 36178190)
90

Data Source:
BioGRID (pull down)

		PTPRU	OSTN
Description		protein tyrosine phosphatase receptor type U	osteocrin
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Anchoring Junction	Extracellular Region Extracellular Space
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Hydrolase Activity	Signaling Receptor Binding Hormone Activity
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Population Proliferation Cell Differentiation Negative Regulation Of Cell Migration Animal Organ Regeneration Neuron Projection Development Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Endochondral Bone Growth CGMP Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Blood Pressure Hormone-mediated Signaling Pathway Cell Differentiation Regulation Of Osteoblast Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of D-glucose Import Bone Growth Negative Regulation Of Dendrite Extension
Pathways		Signaling by SCF-KIT
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Appendicular lean mass ( 33097823) Bipolar disorder and schizophrenia ( 20889312) Blood protein levels ( 30072576) Carotid plaque maximum area ( 32469969) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Mean area of carotid plaque ( 32469969) Mean corpuscular volume ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Schizophrenia ( 28991256) Tourette syndrome ( 30818990)	Cerebrospinal P-tau181p levels ( 28247064) Cerebrospinal T-tau levels ( 28247064) Cortical volume ( 32963231) Height ( 31562340) Lateral ventricular volume in normal aging ( 30258056) Psoriasis ( 25903422) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		12 interacting genes: CTNNB1 EGFR ERBB2 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT OMG OSTN PPFIA3	1 interacting genes: PTPRU
Entrez ID		10076	344901
HPRD ID		03908	17809
Ensembl ID		ENSG00000060656	ENSG00000188729
Uniprot IDs		Q92729	P61366
PDB IDs		6SUB 6SUC
Enriched GO Terms of Interacting Partners?		Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway G Protein-coupled Serotonin Receptor Binding Ciliary Basal Body Negative Regulation Of Insulin Secretion Negative Regulation Of Secretion By Cell Adenylate Cyclase Regulator Activity Negative Regulation Of Peptide Secretion Negative Regulation Of Secretion Transmembrane Receptor Protein Tyrosine Kinase Activity Midbody Negative Regulation Of Transport Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of MAPK Cascade Epidermal Growth Factor Receptor Signaling Pathway ERBB2-EGFR Signaling Pathway ERBB Signaling Pathway Plasma Membrane Basolateral Plasma Membrane Cell Surface Receptor Signaling Pathway Negative Regulation Of Hormone Secretion G Protein-coupled Receptor Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Negative Regulation Of Protein Secretion Negative Regulation Of Adenylate Cyclase Activity Regulation Of Protein Localization Positive Regulation Of Cell Population Proliferation Presynaptic Active Zone Cytoplasmic Component Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kinase Binding GTPase Activity Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Regulation Of MAPK Cascade Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Transport Nucleotide Binding Protein Tyrosine Kinase Activity G Protein-coupled Serotonin Receptor Signaling Pathway Signal Transduction GTP Binding Cell Population Proliferation Presynaptic Membrane ERBB2 Signaling Pathway Negative Regulation Of Establishment Of Protein Localization Signaling Receptor Binding Regulation Of Cell Communication	Transmembrane Receptor Protein Tyrosine Phosphatase Activity Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Protein Localization To Cell Surface Animal Organ Regeneration Homotypic Cell-cell Adhesion Beta-catenin Binding Negative Regulation Of Canonical Wnt Signaling Pathway Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Dephosphorylation Regeneration Phosphoprotein Phosphatase Activity Response To Glucocorticoid Response To Corticosteroid
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