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PTPRU and PPFIA3
Number of citations of the paper that reports this interaction (PMID
9624153
)
49
Data Source:
HPRD
(in vitro)
PTPRU
PPFIA3
Gene Name
protein tyrosine phosphatase, receptor type, U
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cytosol
Cell Surface
Presynaptic Active Zone
Molecular Function
Protein Tyrosine Phosphatase Activity
Transmembrane Receptor Protein Tyrosine Phosphatase Activity
Protein Binding
Beta-catenin Binding
Protein Binding
Biological Process
Protein Dephosphorylation
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway
Negative Regulation Of Cell Proliferation
Single Organismal Cell-cell Adhesion
Cell Differentiation
Negative Regulation Of Cell Migration
Organ Regeneration
Homotypic Cell-cell Adhesion
Protein Localization To Cell Surface
Peptidyl-tyrosine Dephosphorylation
Response To Glucocorticoid
Canonical Wnt Signaling Pathway
Synaptic Transmission
Neurotransmitter Secretion
Glutamate Secretion
Regulation Of Short-term Neuronal Synaptic Plasticity
Pathways
Signaling by SCF-KIT
Dopamine Neurotransmitter Release Cycle
Neurotransmitter Release Cycle
Acetylcholine Neurotransmitter Release Cycle
Norepinephrine Neurotransmitter Release Cycle
Serotonin Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Bipolar disorder and schizophrenia (
20889312
)
Non-alcoholic fatty liver disease (
23535911
)
Prostate cancer (gene x gene interaction) (
22219177
)
Protein-Protein Interactions
8 interactors:
CTNNB1
GNAI1
GNAI2
GNAI3
GNAO1
IRS1
KIT
PPFIA3
12 interactors:
CAST
ERC2
GIT1
PPFIA1
PPFIA2
PPFIBP1
PPFIBP2
PTPRD
PTPRF
PTPRG
PTPRS
PTPRU
Entrez ID
10076
8541
HPRD ID
03908
04393
Ensembl ID
ENSG00000060656
ENSG00000177380
Uniprot IDs
Q92729
O75145
PDB IDs
Enriched GO Terms of Interacting Partners
?
Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger
Synaptic Transmission
Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway
Cell Activation
Cell-cell Signaling
Cell Surface Receptor Signaling Pathway
Cell Division
Response To Stress
Signaling
Cell Communication
Negative Regulation Of Adenylate Cyclase Activity
Negative Regulation Of Lyase Activity
Regulation Of Calcium Ion Transport
Platelet Activation
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Negative Regulation Of CAMP Biosynthetic Process
Regulation Of Phosphorus Metabolic Process
Negative Regulation Of CAMP Metabolic Process
Positive Regulation Of Mesenchymal Cell Proliferation
Negative Regulation Of Nucleotide Metabolic Process
Positive Regulation Of Cell Proliferation
Response To Organonitrogen Compound
Regulation Of Mesenchymal Cell Proliferation
Positive Regulation Of Phosphorylation
Regulation Of Synaptic Transmission
Regulation Of Phosphatidylinositol 3-kinase Activity
Vesicle Fusion
Response To Hormone
Regulation Of Adenylate Cyclase Activity
Regulation Of Neuronal Synaptic Plasticity
Signal Transduction
Regulation Of Lipid Kinase Activity
Regulation Of Cyclase Activity
Positive Regulation Of Stem Cell Proliferation
Organelle Fusion
Blood Coagulation
Hemostasis
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of MAPK Cascade
Mast Cell Cytokine Production
Melanocyte Adhesion
Dendritic Cell Cytokine Production
Mast Cell Proliferation
Response To Peptide Hormone
Regulation Of CAMP Biosynthetic Process
Response To Peptide
Regulation Of Catalytic Activity
Positive Regulation Of Kinase Activity
Positive Regulation Of Signal Transduction
Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway
Peptidyl-tyrosine Dephosphorylation
Protein Dephosphorylation
Cell Adhesion
Enzyme Linked Receptor Protein Signaling Pathway
Dephosphorylation
Signaling
Cell Communication
Glutamate Secretion
Signal Transduction
Acid Secretion
Dicarboxylic Acid Transport
Cell Surface Receptor Signaling Pathway
Cellular Response To Stimulus
Neurotransmitter Secretion
Regulation Of Neurotransmitter Levels
Amino Acid Transport
Neurotransmitter Transport
Cell-matrix Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Negative Regulation Of Cell Migration
Negative Regulation Of Receptor Binding
Cell-substrate Adhesion
Presynaptic Membrane Assembly
Negative Regulation Of Cell Motility
Phosphate-containing Compound Metabolic Process
Negative Regulation Of Stress Fiber Assembly
Negative Regulation Of Cellular Component Movement
Response To Stimulus
Presynaptic Membrane Organization
Negative Regulation Of Locomotion
Negative Regulation Of Actin Filament Bundle Assembly
Negative Regulation Of Establishment Of Protein Localization To Plasma Membrane
Cellular Protein Modification Process
Corpus Callosum Development
Carboxylic Acid Transport
Organic Acid Transport
Protein Localization To Cell Surface
Negative Regulation Of Protein Localization To Plasma Membrane
Membrane Assembly
RRNA Transcription
Regulation Of Neuron Projection Development
Nervous System Development
Termination Of RNA Polymerase I Transcription
Transcription Elongation From RNA Polymerase I Promoter
Membrane Biogenesis
Tagcloud
?
adhesion
adjacent
attenuation
catenin
colon
delivered
dephosphorylating
find
focal
fragment
full
gastric
isoform
kda
knockdown
lentivirus
localized
lowly
lysine
phosphatase
reducing
relatively
respective
serve
shrna
suppressor
tissues
tyrosine
Tagcloud (Difference)
?
adhesion
adjacent
attenuation
catenin
colon
delivered
dephosphorylating
find
focal
fragment
full
gastric
isoform
kda
knockdown
lentivirus
localized
lowly
lysine
phosphatase
reducing
relatively
respective
serve
shrna
suppressor
tissues
tyrosine
Tagcloud (Intersection)
?