WASH1 and RNF2

Number of citations of the paper that reports this interaction (PMID 24980959)
0

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		WASH1	RNF2
Gene Name		WAS protein family homolog 1	ring finger protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Exocyst Early Endosome Early Endosome Membrane Recycling Endosome Recycling Endosome Membrane WASH Complex Invadopodium	Ubiquitin Ligase Complex Euchromatin Sex Chromatin Nucleus Nucleoplasm Nuclear Body PcG Protein Complex PRC1 Complex MLL1 Complex
	Molecular Function	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Alpha-tubulin Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity RING-like Zinc Finger Domain Binding
	Biological Process	Exocytosis Endosomal Transport Extracellular Matrix Disassembly Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi Retrograde Transport, Endosome To Plasma Membrane	Negative Regulation Of Transcription From RNA Polymerase II Promoter Mitotic Cell Cycle Gastrulation With Mouth Forming Second Transcription, DNA-templated Anterior/posterior Axis Specification Histone H2A Monoubiquitination Histone H2A-K119 Monoubiquitination
Pathways			Oxidative Stress Induced Senescence Cellular Senescence
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: BECN1 BLOC1S2 KIAA0196 KIAA1033 RNF2	54 interactors: ABCB1 AMBRA1 BMI1 CASP3 CASP9 CBX4 CBX6 CBX7 CBX8 HIST1H2AB HIST2H2AA3 HIST2H2AC HIST3H3 KAT8 KMT2A L3MBTL2 MBD1 OTUD6A PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PGP PHB2 PHC1 PSMC4 RING1 RRM1 RYBP SMURF2 SSX2 TARDBP TFCP2 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2J1 UBE2K UBE2L3 UBE2U UBE2V1 UBE2V2 UBE2W UBE3A USP11 USP19 USP7 WASH1
Entrez ID		100287171	6045
HPRD ID			07028
Ensembl ID			ENSG00000121481
Uniprot IDs		A8K0Z3	B3KRH1 Q99496
PDB IDs			2H0D 3GS2 3H8H 3IXS 3RPG
Enriched GO Terms of Interacting Partners?		Endosomal Transport Intracellular Transport Cellular Response To Aluminum Ion Establishment Of Localization In Cell Positive Regulation Of Mitochondrion Degradation CVT Pathway Histone H2A-K119 Monoubiquitination Cellular Localization Response To Aluminum Ion Late Endosome To Vacuole Transport Organelle Organization Regulation Of Mitochondrion Degradation Mitochondrial Outer Membrane Permeabilization Platelet Dense Granule Organization Histone H2A Monoubiquitination Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Macroautophagy Histone H2A Ubiquitination Endomembrane System Organization Cellular Response To Nitrogen Starvation Positive Regulation Of Mitochondrial Membrane Permeability Response To Vitamin E Histone Monoubiquitination Anterograde Synaptic Vesicle Transport Nucleophagy Beta-amyloid Metabolic Process Microtubule Nucleation Melanosome Organization Protein Targeting To Vacuole Pigment Granule Organization Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Cellular Response To Epidermal Growth Factor Stimulus Establishment Of Protein Localization To Vacuole Microtubule Polymerization Anterograde Axon Cargo Transport Response To Epidermal Growth Factor Endosome Organization Histone Ubiquitination Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Autophagy Regulation Of Membrane Permeability Transport Secretory Granule Organization Protein Monoubiquitination Microtubule Polymerization Or Depolymerization Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Autophagic Vacuole Assembly Axon Cargo Transport Cellular Defense Response Lysosome Organization	Protein Modification By Small Protein Conjugation Protein Ubiquitination Protein Polyubiquitination Protein K48-linked Ubiquitination Cellular Protein Modification Process Histone Ubiquitination Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein K11-linked Ubiquitination Cellular Protein Catabolic Process Chromatin Modification Cellular Macromolecule Catabolic Process Protein Catabolic Process Cellular Metabolic Process Chromatin Organization Cellular Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Transcription, DNA-templated Chromosome Organization Histone Modification RNA Biosynthetic Process Protein Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Proteolysis Protein Monoubiquitination Negative Regulation Of RNA Biosynthetic Process Nitrogen Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Catabolic Process Cellular Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Protein K63-linked Ubiquitination Macromolecule Biosynthetic Process Metabolic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Gene Expression Regulation Of Nucleic Acid-templated Transcription Gene Expression Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression
Tagcloud ?			aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Difference) ?			aldrich ambra1 arp2 associates autophagy becn1 cul4a ddb1 e3 elusive endosomal impairs impede interactor k48 k63 ligase linkage pik3c3 potentiates scar sorting starvation suppresses ubiquitinate ubiquitination wash wasp wiskott
Tagcloud (Intersection) ?