WASHC1 and BLOC1S2

Number of citations of the paper that reports this interaction (PubMedID 23974797)
47

Data Source:
BioGRID (two hybrid)

		WASHC1	BLOC1S2
Description		WASH complex subunit 1	biogenesis of lysosomal organelles complex 1 subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Exocyst Cytoplasm Endosome Early Endosome Late Endosome Autophagosome Centriole Cytosol Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Recycling Endosome Recycling Endosome Membrane WASH Complex	Gamma-tubulin Complex Nucleus Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Centrosome Cytosol Cytoskeleton Membrane BLOC-1 Complex Cytoplasmic Side Of Lysosomal Membrane BORC Complex Axon Cytoplasm
	Molecular Function	Actin Binding Protein Binding Ubiquitin Protein Ligase Binding Alpha-tubulin Binding Gamma-tubulin Binding Phosphatidylinositol 3-kinase Inhibitor Activity	Protein Binding Gamma-tubulin Binding
	Biological Process	Exocytosis Negative Regulation Of Autophagy Protein Transport Endosomal Transport Extracellular Matrix Disassembly Positive Regulation Of Cell Migration Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Ubiquitination Endocytic Recycling Arp2/3 Complex-mediated Actin Nucleation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Retrograde Transport, Endosome To Golgi	Microtubule Nucleation Anterograde Axonal Transport Positive Regulation Of Cell Population Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Endosomal Transport Neuron Projection Development Lysosome Localization Melanosome Organization Positive Regulation Of DNA-templated Transcription Anterograde Synaptic Vesicle Transport Regulation Of Endosome Size Platelet Dense Granule Organization Regulation Of Lysosome Size Organelle Transport Along Microtubule Mitochondrial Outer Membrane Permeabilization
Pathways
Drugs
Diseases
GWAS			Refractive error ( 32231278)
Interacting Genes		54 interacting genes: ABI2 ABI3 ATPAF2 BECN1 BLOC1S2 C14orf119 C1orf216 CDR2L CEP55 EIF3F EXOC8 FHL2 GYS1 HGS HSBP1 HSF2BP IFT57 KANK2 KLC3 KRT20 KRT26 KRT28 KRT3 KRT75 KRT76 LIMK1 LMO1 LMO2 LMO3 LMO4 MORN4 MRFAP1 NDC80 NUP62CL OIP5 OSTF1 POLR1C PRKAA2 RABGEF1 RNF2 SDCBP SMARCD1 TPM1 TPM3 TRIM69 TSG101 TTC19 TXLNA UBL5 USP20 WASHC3 WASHC4 WASHC5 ZBTB16	36 interacting genes: APP ARFIP2 BFSP2 BLOC1S1 BLOC1S3 BLOC1S4 BLOC1S5 BLOC1S6 C8orf33 CCDC146 CCHCR1 CCNC CTNNA3 DCTN2 ERP27 EXOC8 FAM161B FAM9B GADD45G GEM HMOX2 KRT26 MEST P4HA3 PAM16 PICK1 RDH11 SH2D4A SNAPIN SSC5D STX2 TNNT1 TRIML2 TTC3 WASHC1 WASHC3
Entrez ID		100287171	282991
HPRD ID			12526
Ensembl ID		ENSG00000181404	ENSG00000196072
Uniprot IDs		A8K0Z3	A0A087X1N6 F1T0F0 Q6QNY1
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Supramolecular Fiber Organization Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Organelle Organization Cytoskeleton Organization Endosomal Transport Regulation Of Arp2/3 Complex-mediated Actin Nucleation Actin-based Cell Projection Protein Binding Regulation Of Actin Nucleation Endosome Organization Organelle Localization Intermediate Filament Regulation Of Organelle Organization Positive Regulation Of Exosomal Secretion WASH Complex Transport Along Microtubule Regulation Of Actin Filament Organization Regulation Of Exosomal Secretion Cytoskeleton Cytoskeleton-dependent Intracellular Transport Early Endosome Membrane Cellular Localization Intracellular Transport Muscle Thin Filament Tropomyosin Microtubule-based Transport Cytosol Regulation Of Actin Cytoskeleton Organization Axo-dendritic Transport Regulation Of Extracellular Exosome Assembly Actin Filament Organization Establishment Of Organelle Localization Establishment Of Localization In Cell Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Protein Localization To Vacuole Late Endosome To Vacuole Transport Cytoskeleton-dependent Cytokinesis Regulation Of Cytoskeleton Organization Identical Protein Binding Cytoplasm Nuclear Speck Membrane Fission Exocytosis Vesicle Organization Regulation Of Stress Granule Assembly Cell Division	Anterograde Synaptic Vesicle Transport BLOC-1 Complex Synaptic Vesicle Transport Melanosome Organization Pigment Granule Organization Axo-dendritic Transport Anterograde Axonal Transport Vesicle Transport Along Microtubule Vesicle Cytoskeletal Trafficking Establishment Of Vesicle Localization Axon Cytoplasm Axonal Transport Vesicle Localization Organelle Localization Organelle Transport Along Microtubule Intracellular Transport Transport Along Microtubule Melanosome Transport Cellular Localization Establishment Of Melanosome Localization Pigment Granule Transport Cytoskeleton-dependent Intracellular Transport Establishment Of Localization In Cell Melanosome Localization Pigment Granule Localization Vesicle Organization Regulation Of Arp2/3 Complex-mediated Actin Nucleation Microtubule-based Transport Microvesicle Regulation Of Actin Nucleation Plasma Membrane Bounded Cell Projection Organization Endosome To Melanosome Transport Microtubule-based Movement Establishment Of Organelle Localization Protein Transport Cell Projection Organization Secretion By Cell Organelle Organization Membrane Curvature Sensor Activity Microtubule-based Process Establishment Of Protein Localization Secretion Of Lysosomal Enzymes Neuron Projection Development Exocytosis Positive Regulation Of Pigment Cell Differentiation Secretion Regulation Of Lysosome Size BORC Complex Positive Regulation Of Developmental Pigmentation Pigmentation
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