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GNE and KRTAP5-9
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
GNE
KRTAP5-9
Gene Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
keratin associated protein 5-9
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Keratin Filament
Molecular Function
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Metal Ion Binding
Protein Binding
Biological Process
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Cell Adhesion
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Carbohydrate Phosphorylation
Epidermis Development
Pathways
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MOGS causes MOGS-CDG (CDG-2b)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Post-translational protein modification
Defective ALG3 causes ALG3-CDG (CDG-1d)
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Sialic acid metabolism
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions
17 interactors:
ADAMTSL4
CRMP1
GTPBP3
KIAA1549
KRT31
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP5-9
KRTAP9-2
NOTCH2NL
RIF1
SPRY2
ZBTB16
103 interactors:
ADAMTSL4
ALPP
ATG9A
BEX2
BMP7
C10orf62
C11orf87
C19orf66
CARKD
CATSPER1
CHIC2
CHRD
CKS1B
CNNM3
COMT
CRCT1
CTSZ
CXCL16
DHRS1
DMRT3
DOCK2
FAH
FAM124B
FAM161A
FAM74A4
FAM76B
GLRX3
GNE
HOXA1
HOXB9
HPCAL1
HSPD1
JOSD1
KLHL38
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-1
KRTAP12-2
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP9-2
KRTAP9-4
LCE1B
LCE2A
LCE3C
LCE3E
LCE4A
LY6H
MAPKBP1
MEOX2
NCLN
NLK
NMU
NOTCH2NL
NPBWR2
NPDC1
NTM
NTN4
NUFIP2
OTX1
P2RX4
PCSK5
PFKL
PGLS
POM121L8P
PRKAB2
PSMA1
PTPMT1
PVRL2
RAMP3
RGS20
RNF111
SCARB1
SDC3
SDCBP
SLC22A23
SLC25A10
SMCP
SPINK2
SPRY2
TBC1D10C
TBC1D16
TCEA2
TCEANC
TOMM22
TYRO3
WDYHV1
YIPF3
ZBTB24
ZFYVE21
ZNF124
ZNF266
ZNF417
ZNF439
ZNF581
ZNF587
Entrez ID
10020
3846
HPRD ID
04825
01008
Ensembl ID
ENSG00000159921
ENSG00000254997
Uniprot IDs
H0YFA7
Q9Y223
P26371
PDB IDs
2YHW
2YHY
2YI1
3EO3
Enriched GO Terms of Interacting Partners
?
Keratinization
Keratinocyte Differentiation
Pattern Specification Process
Epidermal Cell Differentiation
Developmental Process
Positive Regulation Of Immune Response To Tumor Cell
Adhesion Of Symbiont To Host
Locomotion
Negative Regulation Of Cardiac Muscle Hypertrophy
Negative Regulation Of Muscle Hypertrophy
Organ Development
Cell Recognition
Skin Development
Multicellular Organismal Development
Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin
Anterior/posterior Pattern Specification
Cell Differentiation
System Development
Epidermis Development
Transcription, DNA-templated
Tagcloud
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Difference)
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Intersection)
?