KRTAP5-9 and FLT3LG

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP5-9	FLT3LG
Description		keratin associated protein 5-9	fms related receptor tyrosine kinase 3 ligand
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Extracellular Region Extracellular Space Cytosol Plasma Membrane Cell Surface Membrane
	Molecular Function	Protein Binding Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Protein Binding Receptor Tyrosine Kinase Binding
	Biological Process	Epidermis Development	Signal Transduction Positive Regulation Of Cell Population Proliferation B Cell Differentiation Positive Regulation Of Natural Killer Cell Proliferation Embryonic Hemopoiesis Dendritic Cell Differentiation
Pathways		Keratinization	PI3K Cascade PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling FLT3 Signaling FLT3 Signaling STAT5 Activation Negative regulation of FLT3 FLT3 signaling through SRC family kinases FLT3 signaling through SRC family kinases FLT3 signaling by CBL mutants
Drugs
Diseases
GWAS			Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		201 interacting genes: ABHD17A ADAM12 ADAMTSL4 ADAMTSL5 ALDH3B1 ALPP ATG9A BEX2 BMP7 BRME1 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CHRNG CKS1B CNNM3 COL8A1 COMT CRCT1 CREB5 CRH CRY2 CTNNBIP1 CTSZ CXCL16 CYSRT1 DCDC2 DHRS1 DMRT3 DNASE1L3 DOCK2 EMC7 ENKD1 ENPP7 FAH FAM124B FAM161A FAM74A4 FAM76B FLT3LG GGN GLP1R GLRX3 GNE GRN GSC2 HEY2 HHEX HLCS HOXA1 HOXB9 HPCAL1 HSD3B7 HSPD1 ICAM4 IGFBP6 JOSD1 KLHL38 KLK8 KPRP KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 LY6H MAPKBP1 MEOX2 MOBP MT1M NAXD NBPF19 NCLN NECTIN2 NECTIN3 NKD1 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NR4A3 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 P2RY6 P4HB PCSK5 PDE9A PFKL PGAP6 PGLS PHLDA1 PIN1 POM121L8P POTEB3 POU4F2 PRKAB2 PSMA1 PTK7 PTPMT1 RAMP3 RASD1 RGS20 RNF111 SCARB1 SCNM1 SDC3 SDCBP SEMA3B SHFL SLC13A5 SLC15A3 SLC22A23 SLC25A10 SLC6A20 SMCP SPATA3 SPATC1L SPG7 SPINK2 SPRY1 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TGM1 TOMM22 TRARG1 TYRO3 UBE2I UXT VWC2 WNT11 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF581 ZNF587 ZNF655 ZNF696 ZNF837	5 interacting genes: FLT3 KITLG KRTAP5-9 PFN2 S100A6
Entrez ID		3846	2323
HPRD ID		01008	02477
Ensembl ID		ENSG00000254997	ENSG00000090554
Uniprot IDs		P26371	B7ZLY4 P49771
PDB IDs			1ETE 3QS7 3QS9 7NBI 7QDP 7ZV9
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Protein Binding Tissue Development Hair Cycle Axis Elongation	Positive Regulation Of Cell Population Proliferation Lymphocyte Proliferation Leukocyte Proliferation Hematopoietic Progenitor Cell Differentiation Vascular Endothelial Growth Factor Receptor Activity Positive Regulation Of Phosphorylation Common Myeloid Progenitor Cell Proliferation Pro-B Cell Differentiation Myeloid Progenitor Cell Differentiation Mononuclear Cell Proliferation Phosphatidylinositol 3-kinase Activator Activity Hemopoiesis Positive Regulation Of Protein Phosphorylation Mast Cell Apoptotic Process Regulation Of Melanocyte Differentiation Positive Regulation Of Mast Cell Proliferation Negative Regulation Of Mast Cell Apoptotic Process Melanocyte Migration Mast Cell Proliferation Mast Cell Migration Regulation Of Mast Cell Apoptotic Process Positive Regulation Of Pigment Cell Differentiation Positive Regulation Of Hematopoietic Progenitor Cell Differentiation Stem Cell Factor Receptor Binding Positive Regulation Of Melanocyte Differentiation Presynaptic Actin Cytoskeleton Organization Presynaptic Cytoskeleton Organization Negative Regulation Of Ruffle Assembly Positive Regulation Of Developmental Pigmentation Regulation Of Mast Cell Proliferation Positive Regulation Of Hematopoietic Stem Cell Proliferation Lymphoid Progenitor Cell Differentiation Positive Regulation Of Phosphate Metabolic Process Modification Of Postsynaptic Actin Cytoskeleton Monoatomic Ion Transmembrane Transporter Activity Regulation Of Developmental Pigmentation Tropomyosin Binding Nuclear Glucocorticoid Receptor Binding S100 Protein Binding Leukocyte Differentiation Positive Regulation Of Protein Modification Process Myeloid Cell Apoptotic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Protein Phosphorylation Regulation Of Hematopoietic Stem Cell Proliferation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Ras Protein Signal Transduction Vascular Endothelial Growth Factor Signaling Pathway Regulation Of Phosphorylation Modification Of Postsynaptic Structure
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