GNE and KIAA1549

Number of citations of the paper that reports this interaction (PMID 17118363)
6

Data Source:
HPRD (two hybrid)

		GNE	KIAA1549
Gene Name		glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	KIAA1549
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol	Integral Component Of Membrane
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Cell Adhesion Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Carbohydrate Phosphorylation
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions		17 interactors: ADAMTSL4 CRMP1 GTPBP3 KIAA1549 KRT31 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP5-9 KRTAP9-2 NOTCH2NL RIF1 SPRY2 ZBTB16	10 interactors: CADPS CDC73 DST GNE ITSN2 LGALS4 MBD5 MYO5B SOD2 ZBTB16
Entrez ID		10020	57670
HPRD ID		04825	13873
Ensembl ID		ENSG00000159921	ENSG00000122778
Uniprot IDs		H0YFA7 Q9Y223	Q9HCM3
PDB IDs		2YHW 2YHY 2YI1 3EO3
Enriched GO Terms of Interacting Partners?			Negative Regulation Of Fibroblast Proliferation Erythrophore Differentiation Age-dependent Response To Reactive Oxygen Species Vasodilation By Acetylcholine Involved In Regulation Of Systemic Arterial Blood Pressure Negative Regulation Of Myeloid Cell Differentiation Regulation Of Fibroblast Proliferation N-acetylglucosamine Biosynthetic Process Positive Regulation Of Growth Hormone Receptor Signaling Pathway Response To Silicon Dioxide Response To Magnetism Regulation Of Fat Cell Differentiation Catecholamine Secretion Regulation Of Growth Hormone Receptor Signaling Pathway Age-dependent Response To Oxidative Stress Positive Regulation Of NK T Cell Differentiation Detection Of Oxygen Negative Regulation Of Cell Proliferation Regulation Of Myeloid Cell Differentiation Male Germ-line Stem Cell Asymmetric Division Response To Selenium Ion Endosome Localization Negative Regulation Of Cell Differentiation Oxygen Homeostasis Cellular Response To Ethanol N-acetylneuraminate Metabolic Process Histone H2B Ubiquitination Hydrogen Peroxide Biosynthetic Process Synaptic Vesicle Priming Response To Isolation Stress
Tagcloud ?		15s alphap competition contaminant doublet eif2 eif2alpha eif2b exchange gdp germ gtp guanine heme impairs inability insects interact lysates nucleotides p41 presumably residue reticulocyte unable unlike wg wheat x	10q 3q26 6q23 7q34 9q astrocytoma chek2 dnt dysembryoplastic encompassed fam131b fibrillary ganglioglioma gliomas lggs mbs medulloblastomas neuroepithelial nf1 nf2 philadelphia pilocytic q10 qki refine sanger thr599dup tier v600e
Tagcloud (Difference) ?		15s alphap competition contaminant doublet eif2 eif2alpha eif2b exchange gdp germ gtp guanine heme impairs inability insects interact lysates nucleotides p41 presumably residue reticulocyte unable unlike wg wheat x	10q 3q26 6q23 7q34 9q astrocytoma chek2 dnt dysembryoplastic encompassed fam131b fibrillary ganglioglioma gliomas lggs mbs medulloblastomas neuroepithelial nf1 nf2 philadelphia pilocytic q10 qki refine sanger thr599dup tier v600e
Tagcloud (Intersection) ?