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GNE and KRTAP9-2
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
GNE
KRTAP9-2
Gene Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
keratin associated protein 9-2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Keratin Filament
Molecular Function
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Metal Ion Binding
Biological Process
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Cell Adhesion
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Carbohydrate Phosphorylation
Pathways
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MOGS causes MOGS-CDG (CDG-2b)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Post-translational protein modification
Defective ALG3 causes ALG3-CDG (CDG-1d)
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Sialic acid metabolism
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions
17 interactors:
ADAMTSL4
CRMP1
GTPBP3
KIAA1549
KRT31
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP5-9
KRTAP9-2
NOTCH2NL
RIF1
SPRY2
ZBTB16
54 interactors:
ADAMTSL4
AQP1
ARFGAP1
C19orf66
CATSPER1
CCDC28A
CHRD
COL8A1
CREB5
DOCK2
FAM76B
GATA1
GLRX3
GNE
HOXA1
JOSD1
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP26-1
KRTAP3-2
KRTAP4-12
KRTAP4-2
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-4
LCE1B
LCE2A
LCE3E
LCE4A
LNX1
MAPKBP1
MEOX2
NOTCH2NL
NUFIP2
OTX1
PDE9A
PLSCR1
PRKAB2
PTPMT1
RCHY1
RNF31
SMCP
SPATA8
SPRY2
SUMO1P1
TMSB10
WDYHV1
ZDHHC17
Entrez ID
10020
83899
HPRD ID
04825
13949
Ensembl ID
ENSG00000159921
ENSG00000239886
Uniprot IDs
H0YFA7
Q9Y223
Q9BYQ4
PDB IDs
2YHW
2YHY
2YI1
3EO3
Enriched GO Terms of Interacting Partners
?
Keratinization
Keratinocyte Differentiation
Epithelium Development
Tissue Development
Organ Development
Epidermis Development
Epidermal Cell Differentiation
Developmental Process
Skin Development
Multicellular Organismal Development
Inner Ear Morphogenesis
Cell Differentiation
Ear Morphogenesis
Embryo Development
System Development
Sensory Organ Development
BMP Signaling Pathway Involved In Spinal Cord Dorsal/ventral Patterning
Metanephric Descending Thin Limb Development
Metanephric Proximal Straight Tubule Development
Metanephric Proximal Convoluted Tubule Segment 2 Development
Abducens Nerve Formation
Maintenance Of Symbiont-containing Vacuole By Host
Transepithelial Water Transport
Optokinetic Behavior
Localization Within Membrane
Ammonium Transmembrane Transport
Anatomical Structure Development
Embryonic Morphogenesis
Establishment Or Maintenance Of Cell Polarity
Inner Ear Development
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Myeloid Dendritic Cell Activation Involved In Immune Response
Facial Nucleus Development
Basophil Differentiation
Carbon Dioxide Transmembrane Transport
Corticotropin Secretion
CD40 Signaling Pathway
Eosinophil Fate Commitment
N-acetylglucosamine Biosynthetic Process
Establishment Or Maintenance Of Actin Cytoskeleton Polarity
Sperm Motility
Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Cell-cell Recognition
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Eosinophil Differentiation
Metanephric Proximal Convoluted Tubule Development
Rhombomere 4 Development
Nitric Oxide Transport
Semicircular Canal Formation
Transcriptional Activation By Promoter-enhancer Looping
Tagcloud
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Difference)
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Intersection)
?