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GNE and TSPAN4
Number of citations of the paper that reports this interaction (PubMedID
32296183
)
50
Data Source:
BioGRID
(two hybrid)
GNE
TSPAN4
Description
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
tetraspanin 4
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Membrane
Vesicle
Molecular Function
Nucleotide Binding
Catalytic Activity
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
Protein Binding
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Kinase Activity
Transferase Activity
Hydrolase Activity
Metal Ion Binding
Antigen Binding
Integrin Binding
Protein Binding
Biological Process
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
CMP-N-acetylneuraminate Biosynthetic Process
N-acetylneuraminate Biosynthetic Process
Carbohydrate Phosphorylation
Glycosylation
Protein-containing Complex Assembly
Pathways
Sialic acid metabolism
Defective GNE causes sialuria, NK and IBM2
Drugs
Diseases
Sialuria/ Sialic acid storage disease, including: Infantile sialic acid storage disease (ISSD); Sialuria, Finnish type / Salla disease (SD); Sialuria, French type
Nonaka distal myopathy (NM); Distal myopathy with rimmed vacuoles (DMRV); Hereditary inclusion body myopathy (hIBM)
Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM)
GWAS
Bipolar disorder (inflammation and infection response interaction) (
25781172
)
Bisphosphonate-associated atypical femoral fracture (
31006051
)
Falling risk (
32999390
)
Interacting Genes
65 interacting genes:
ADAMTSL4
C22orf39
CFP
CRMP1
CYSRT1
ECM1
EGFL7
GRN
GTPBP3
HOXA1
KIAA1549
KPRP
KRT31
KRT34
KRT40
KRT83
KRT85
KRT86
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP11-1
KRTAP12-3
KRTAP13-2
KRTAP13-3
KRTAP17-1
KRTAP19-2
KRTAP19-7
KRTAP3-1
KRTAP3-3
KRTAP4-1
KRTAP4-11
KRTAP4-12
KRTAP4-4
KRTAP5-9
KRTAP6-1
KRTAP6-2
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
MDFI
MGAT5B
NBPF19
NID2
NOTCH2NLA
PLA2G10
PRICKLE4
RIF1
SPRY1
SPRY2
SPRY3
SSC4D
TRIM27
TRIM42
TRIP6
TSPAN4
VWC2
WDR83
WWOX
ZBTB16
49 interacting genes:
CATSPER1
CD46
CD81
CD9
CHRD
CLDN11
CLEC2D
CREB3
CREB5
CYSRT1
EVA1A
FCHO1
FRS3
GNE
GRN
GUCD1
HOXA1
ITGA3
ITGA6
ITGB1
KRTAP10-1
KRTAP10-8
KRTAP4-11
KRTAP4-5
KRTAP6-2
KRTAP9-2
KRTAP9-3
LCE1A
LCE2B
LCE2D
LCE3A
LCE3C
LCE3D
LCE4A
LRRC25
LTB4R2
MDFI
MGAT5B
MKRN3
NBPF19
NOTCH2NLA
NR4A3
OTX1
PHLDA1
PLSCR4
SGPL1
TEKT4
TMEM106A
VGLL3
Entrez ID
10020
7106
HPRD ID
04825
04033
Ensembl ID
ENSG00000159921
ENSG00000214063
Uniprot IDs
A0A7I2SU25
Q9Y223
A8MVV6
O14817
PDB IDs
2YHW
2YHY
2YI1
3EO3
4ZHT
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratin Filament
Structural Constituent Of Skin Epidermis
Cytosol
Hair Cycle
Keratinization
Intermediate Filament Organization
Structural Molecule Activity
Epidermis Development
Intermediate Filament Cytoskeleton Organization
Intermediate Filament-based Process
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Negative Regulation Of Ras Protein Signal Transduction
Protein Binding
Identical Protein Binding
Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Bud Elongation Involved In Lung Branching
Interstitial Matrix
Regulation Of Lens Fiber Cell Differentiation
Regulation Of Ras Protein Signal Transduction
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Keratinization
Epidermis Development
Keratin Filament
Intermediate Filament
Integrin Alpha6-beta1 Complex
Integrin Alpha3-beta1 Complex
Myoblast Fusion Involved In Skeletal Muscle Regeneration
Myoblast Fusion
Integrin Complex
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Lipoprotein Particle Stimulus
Cell-cell Fusion
Syncytium Formation
Syncytium Formation By Plasma Membrane Fusion
Cerebellar Climbing Fiber To Purkinje Cell Synapse
Identical Protein Binding
CAMP Response Element Binding
Regulation Of Cell Motility
Hair Cycle
Regulation Of Locomotion
Integrin Binding
Mesodermal Cell Differentiation
Tissue Development
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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