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GNE and KRT31
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
GNE
KRT31
Gene Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
keratin 31, type I
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Extracellular Space
Intermediate Filament
Extracellular Vesicular Exosome
Molecular Function
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Metal Ion Binding
Structural Constituent Of Cytoskeleton
Biological Process
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Cell Adhesion
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Carbohydrate Phosphorylation
Epidermis Development
Pathways
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MOGS causes MOGS-CDG (CDG-2b)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Post-translational protein modification
Defective ALG3 causes ALG3-CDG (CDG-1d)
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Sialic acid metabolism
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions
17 interactors:
ADAMTSL4
CRMP1
GTPBP3
KIAA1549
KRT31
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP5-9
KRTAP9-2
NOTCH2NL
RIF1
SPRY2
ZBTB16
181 interactors:
ABI2
AES
AGR2
ALDH3B1
ALS2CR11
AMOT
AMOTL2
ANKRD36BP1
AQP1
AQP5
ARHGAP35
ARMC7
ARSJ
ASMTL
ASPSCR1
ATG9A
ATN1
ATXN7L1
BEX2
BTC
BYSL
C12orf49
C19orf73
C1orf109
C1orf216
C5orf60
C6orf165
CA6
CARD9
CARKD
CATIP
CCDC112
CCDC120
CCDC17
CCDC93
CCER1
CCHCR1
CCNC
CD33
CDC20B
CDK18
CDKN1A
CEP57
CEP57L1
CEP70
CHCHD2
CHRNG
CLDN2
COA5
COMT
COX5A
COX5B
CRH
CTSG
DGCR6L
DHX37
DMRT3
DTNB
EIF4E2
EXOC8
FAM103A1
FAM110A
FAM124B
FAM71C
FAM74A4
FAM90A1
FARS2
FBF1
FBXW5
FKBP1B
FOXB1
GEM
GFOD1
GLRX3
GNAI2
GNE
GNG10
GNG5
GPS2
GSTP1
HAUS1
HDAC4
HGS
HOXA1
HSPA12B
HSPD1
ICAM4
INPP5D
INPP5K
INSR
JOSD1
KIFC3
KLC1
KLC4
KLHL38
KRT2
KRT5
KRT6A
KRT6B
KRT6C
KRT71
KRT77
KRT79
KRT8
KRT81
KRT83
LATS1
LCE4A
LENG1
LIN37
LINC00238
LINC00526
LMF2
LMO4
LONRF1
MAP3K7CL
MAPKBP1
MARK4
MRPL40
NAV1
NEK6
NPBWR2
OTUB2
P2RX7
PDE4DIP
PGLS
PIN1
PKN1
PPP1R18
PRF1
PRKAA2
PRR19
PSMA1
PSMG2
PSPC1
PTGER3
PTPMT1
RADIL
RCOR3
RIBC1
RPUSD3
RSPH14
SCNM1
SEMA4C
SHC3
SIRPA
SLC15A3
SLC23A1
SLC25A6
SMARCE1
SMCP
SMG9
SNAI1
SNRNP25
SPATA24
SPON2
SRSF2
SSX2IP
TAPBPL
THAP7
TMEM106C
TMEM231
TMSB4X
TRAF4
TROAP
TSG101
TTC23
TXLNA
USHBP1
UTP23
UXT
WDR25
WDYHV1
ZFYVE21
ZNF124
ZNF148
ZNF20
ZNF569
ZNF572
ZNF69
ZNRF2P1
Entrez ID
10020
3881
HPRD ID
04825
03047
Ensembl ID
ENSG00000159921
ENSG00000094796
Uniprot IDs
H0YFA7
Q9Y223
Q15323
PDB IDs
2YHW
2YHY
2YI1
3EO3
Enriched GO Terms of Interacting Partners
?
Cellular Process
Organelle Organization
Epidermis Development
Anatomical Structure Development
Developmental Process
Negative Regulation Of Cellular Metabolic Process
Cytoskeleton Organization
Positive Regulation Of Urine Volume
G2/M Transition Of Mitotic Cell Cycle
Gene Expression
Regulation Of Body Fluid Levels
Epithelium Development
RNA Metabolic Process
Regulation Of Interleukin-6 Production
Carbon Dioxide Transport
Response To Organic Substance
Regulation Of Glycolytic Process
Mitotic Cell Cycle Process
Hippo Signaling
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Interleukin-6 Production
Cell Cycle
Negative Regulation Of Intracellular Signal Transduction
Regulation Of Stress-activated MAPK Cascade
Pancreatic Juice Secretion
Microtubule Cytoskeleton Organization
Movement Of Cell Or Subcellular Component
Mitotic Cell Cycle Phase Transition
Regulation Of Mitotic Nuclear Division
Regulation Of MAPK Cascade
Regulation Of Cell Cycle
Regulation Of Generation Of Precursor Metabolites And Energy
Cell Cycle Phase Transition
Multicellular Organismal Development
Bicarbonate Transport
Cell Volume Homeostasis
Cell Death
Death
Interaction With Symbiont
Negative Regulation Of Signaling
Transcription, DNA-templated
Mitotic Cell Cycle
Regulation Of Protein Metabolic Process
Apoptotic Process
Negative Regulation Of Protein Serine/threonine Kinase Activity
Response To Fungus
Cellular Response To Extracellular Stimulus
Cellular Metabolic Process
Programmed Cell Death
RNA Biosynthetic Process
Tagcloud
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Difference)
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Intersection)
?