KRTAP5-9 and NLK

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		KRTAP5-9	NLK
Description		keratin associated protein 5-9	nemo like kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Identical Protein Binding	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding SH2 Domain Binding Metal Ion Binding Protein Serine Kinase Activity DNA-binding Transcription Factor Binding
	Biological Process	Epidermis Development	MAPK Cascade Regulation Of DNA-templated Transcription Protein Phosphorylation Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Regulation Of Signal Transduction Wnt Signaling Pathway Peptidyl-threonine Phosphorylation Negative Regulation Of Wnt Signaling Pathway Cellular Response To Nutrient Levels Cellular Response To Stress Intracellular Signal Transduction TORC1 Signaling Protein Stabilization Protein Localization To Lysosome Cellular Response To Osmotic Stress Negative Regulation Of TORC1 Signaling Positive Regulation Of TORC1 Signaling Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		Keratinization	Ca2+ pathway
Drugs
Diseases
GWAS			Non-response to bupropion and depression ( 27622933)
Interacting Genes		201 interacting genes: ABHD17A ADAM12 ADAMTSL4 ADAMTSL5 ALDH3B1 ALPP ATG9A BEX2 BMP7 BRME1 C10orf62 C11orf87 CATSPER1 CHIC2 CHRD CHRNG CKS1B CNNM3 COL8A1 COMT CRCT1 CREB5 CRH CRY2 CTNNBIP1 CTSZ CXCL16 CYSRT1 DCDC2 DHRS1 DMRT3 DNASE1L3 DOCK2 EMC7 ENKD1 ENPP7 FAH FAM124B FAM161A FAM74A4 FAM76B FLT3LG GGN GLP1R GLRX3 GNE GRN GSC2 HEY2 HHEX HLCS HOXA1 HOXB9 HPCAL1 HSD3B7 HSPD1 ICAM4 IGFBP6 JOSD1 KLHL38 KLK8 KPRP KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-10 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP2-3 KRTAP2-4 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 LINGO1 LNX1 LY6H MAPKBP1 MEOX2 MOBP MT1M NAXD NBPF19 NCLN NECTIN2 NECTIN3 NKD1 NLK NMU NOTCH2NLA NPBWR2 NPDC1 NR4A3 NTAQ1 NTM NTN4 NUFIP2 OTX1 P2RX4 P2RY6 P4HB PCSK5 PDE9A PFKL PGAP6 PGLS PHLDA1 PIN1 POM121L8P POTEB3 POU4F2 PRKAB2 PSMA1 PTK7 PTPMT1 RAMP3 RASD1 RGS20 RNF111 SCARB1 SCNM1 SDC3 SDCBP SEMA3B SHFL SLC13A5 SLC15A3 SLC22A23 SLC25A10 SLC6A20 SMCP SPATA3 SPATC1L SPG7 SPINK2 SPRY1 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TGM1 TOMM22 TRARG1 TYRO3 UBE2I UXT VWC2 WNT11 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF408 ZNF414 ZNF417 ZNF439 ZNF440 ZNF581 ZNF587 ZNF655 ZNF696 ZNF837	27 interacting genes: ASGR1 ATXN1 CREBBP CUL1 FBXW5 FOXO4 FOXP3 GRN HIPK2 KRTAP10-1 KRTAP10-3 KRTAP4-2 KRTAP5-6 KRTAP5-9 LEF1 MYB MYBL1 NDOR1 NOTCH1 QRICH1 RCHY1 RPTOR SDR16C5 SKP2 STAT3 USP4 ZHX3
Entrez ID		3846	51701
HPRD ID		01008	17637
Ensembl ID		ENSG00000254997	ENSG00000087095
Uniprot IDs		P26371	Q9UBE8
PDB IDs
Enriched GO Terms of Interacting Partners?		Intermediate Filament Keratin Filament Keratinization Epidermis Development Protein Binding Tissue Development Hair Cycle Axis Elongation	Positive Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell Population Proliferation Cell Population Proliferation Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Intermediate Filament Response To Hypoxia Response To Decreased Oxygen Levels Positive Regulation Of RNA Metabolic Process Response To Oxygen Levels Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Positive Regulation Of Developmental Process T-helper 17 Type Immune Response Regulation Of Cell Development Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Cytosol Regulation Of Glial Cell Proliferation Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Cell Development Positive Regulation Of Cell Differentiation Negative Regulation Of Interleukin-4 Production Positive Regulation Of Odontoblast Differentiation RNA Polymerase II Transcription Regulator Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of Interleukin-5 Production Positive Regulation Of Neuroepithelial Cell Differentiation Positive Regulation Of Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Cell Differentiation Regulation Of DNA-templated Transcription Cellular Response To Stress Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II Leukocyte Activation Involved In Immune Response Cell Activation Involved In Immune Response SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Odontoblast Differentiation
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