GNE

Gene Name		glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds ATP Binding UDP-N-acetylglucosamine 2-epimerase Activity N-acylmannosamine Kinase Activity Metal Ion Binding
	Biological Process	N-acetylglucosamine Biosynthetic Process UDP-N-acetylglucosamine Metabolic Process N-acetylneuraminate Metabolic Process Dolichol-linked Oligosaccharide Biosynthetic Process Cell Adhesion Protein N-linked Glycosylation Via Asparagine Post-translational Protein Modification Cellular Protein Metabolic Process Carbohydrate Phosphorylation
Pathways		Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective MOGS causes MOGS-CDG (CDG-2b) Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Synthesis of substrates in N-glycan biosythesis Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Sialic acid metabolism Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-protein Interactions		17 interactors: ADAMTSL4 CRMP1 GTPBP3 KIAA1549 KRT31 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-12 KRTAP5-9 KRTAP9-2 NOTCH2NL RIF1 SPRY2 ZBTB16
Entrez ID		10020
HPRD ID		04825
Ensembl ID		ENSG00000159921
Uniprot IDs		H0YFA7 Q9Y223
PDB IDs		2YHW 2YHY 2YI1 3EO3
Enriched GO Terms of Interacting Partners?
Tagcloud ?		15s alphap competition contaminant doublet eif2 eif2alpha eif2b exchange gdp germ gtp guanine heme impairs inability insects interact lysates nucleotides p41 presumably residue reticulocyte unable unlike wg wheat x