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GNE and KRTAP10-9
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
GNE
KRTAP10-9
Gene Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
keratin associated protein 10-9
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Keratin Filament
Molecular Function
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Metal Ion Binding
Biological Process
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Cell Adhesion
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Carbohydrate Phosphorylation
Pathways
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MOGS causes MOGS-CDG (CDG-2b)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Post-translational protein modification
Defective ALG3 causes ALG3-CDG (CDG-1d)
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Sialic acid metabolism
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions
17 interactors:
ADAMTSL4
CRMP1
GTPBP3
KIAA1549
KRT31
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP5-9
KRTAP9-2
NOTCH2NL
RIF1
SPRY2
ZBTB16
163 interactors:
ADAMTSL4
AES
ALDH3B1
ALPI
ARFGAP1
ATXN7L1
AVPI1
BCL6B
C10orf62
C11orf87
C16orf59
C19orf57
C19orf66
C5orf60
C9orf9
CARKD
CATIP
CATSPER1
CBX2
CCDC26
CD300LG
CDKL3
CHIC2
CHRD
CHRNG
CKS1B
CLK4
CNNM3
CRCT1
CREB5
CST9L
CXCL16
DHX57
DMRT3
DOCK2
EIF4E2
FAM124B
FAM161A
FAM74A4
FAM76B
FARS2
GABARAPL1
GABARAPL2
GATA2
GLIDR
GLP1R
GLRX3
GNE
GPATCH2L
GSTP1
HBG1
HBZ
HCK
HOXA1
HOXB9
HPCAL1
HSD3B7
IGSF8
INPP5D
IQUB
ITGB5
KAT5
KIF9
KLHL38
KRT20
KRT83
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP12-1
KRTAP26-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LCE1B
LCE2A
LCE2D
LCE3C
LCE3E
LCE4A
LUZP4
MAB21L3
MAPKBP1
MED30
MEOX2
MOBP
MT1DP
MXI1
NOTCH2NL
NPBWR2
NPDC1
NPPB
NR1D2
NUFIP2
OTX1
PGAP2
PGLS
PIN1
PLSCR1
PRKAB2
PRPF31
PTGER3
PVR
PVRL3
RAB7A
RHNO1
RSPO2
SCARB1
SCNM1
SLC23A1
SLC6A20
SMARCE1
SMCP
SPATA3
SPATA8
SPG7
SPRY1
SPRY2
STK16
TBC1D16
TBC1D23
TGOLN2
THAP10
TNFRSF6B
TNP2
TRIM41
TRIM42
TXNDC5
TYMSOS
TYRO3
UTP23
WNT11
WT1-AS
XCL2
ZBTB24
ZBTB38
ZBTB9
ZFYVE26
ZNF124
ZNF155
ZNF20
ZNF264
ZNF317
ZNF417
ZNF439
ZNF440
ZNF473
ZNF564
ZNF572
ZNF578
ZNF581
ZNF587
ZNF625
ZNF697
ZNF699
ZNF792
ZNF844
ZSCAN21
ZSCAN26
Entrez ID
10020
386676
HPRD ID
04825
11195
Ensembl ID
ENSG00000159921
ENSG00000221837
Uniprot IDs
H0YFA7
Q9Y223
P60411
PDB IDs
2YHW
2YHY
2YI1
3EO3
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Biosynthetic Process
RNA Metabolic Process
Gene Expression
Nucleobase-containing Compound Metabolic Process
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Biosynthetic Process
Keratinization
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of RNA Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Gene Expression
Regulation Of Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of Cellular Process
Cellular Process
Keratinocyte Differentiation
Cellular Metabolic Process
Epidermis Development
Epidermal Cell Differentiation
Lung Growth
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Negative Regulation Of ERK1 And ERK2 Cascade
Regulation Of Phagocytosis
Regulation Of Transcription From RNA Polymerase II Promoter
Developmental Process
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Regulation Of Podosome Assembly
Apoptotic Cell Clearance
Penetration Of Zona Pellucida
Organelle Disassembly
Tissue Development
Skin Development
Epithelium Development
Multicellular Organismal Development
Bud Elongation Involved In Lung Branching
Cellular Response To Lipid
Epithelial Tube Branching Involved In Lung Morphogenesis
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Fertilization
Negative Regulation Of ERBB Signaling Pathway
Phagocytosis
Anatomical Structure Development
Tagcloud
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Difference)
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Intersection)
?