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GNE and KRTAP10-5
Number of citations of the paper that reports this interaction (PMID
25416956
)
0
Data Source:
BioGRID
(two hybrid)
GNE
KRTAP10-5
Gene Name
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
keratin associated protein 10-5
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Keratin Filament
Molecular Function
Hydrolase Activity, Hydrolyzing O-glycosyl Compounds
ATP Binding
UDP-N-acetylglucosamine 2-epimerase Activity
N-acylmannosamine Kinase Activity
Metal Ion Binding
Biological Process
N-acetylglucosamine Biosynthetic Process
UDP-N-acetylglucosamine Metabolic Process
N-acetylneuraminate Metabolic Process
Dolichol-linked Oligosaccharide Biosynthetic Process
Cell Adhesion
Protein N-linked Glycosylation Via Asparagine
Post-translational Protein Modification
Cellular Protein Metabolic Process
Carbohydrate Phosphorylation
Pathways
Diseases of glycosylation
Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)
Defective MGAT2 causes MGAT2-CDG (CDG-2a)
Defective ALG1 causes ALG1-CDG (CDG-1k)
Defective MOGS causes MOGS-CDG (CDG-2b)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective ALG9 causes ALG9-CDG (CDG-1l)
Defective MAN1B1 causes MRT15
Defective ALG11 causes ALG11-CDG (CDG-1p)
Defective ALG2 causes ALG2-CDG (CDG-1i)
Post-translational protein modification
Defective ALG3 causes ALG3-CDG (CDG-1d)
Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Synthesis of substrates in N-glycan biosythesis
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective ALG6 causes ALG6-CDG (CDG-1c)
Defective RFT1 causes RFT1-CDG (CDG-1n)
Asparagine N-linked glycosylation
Defective ALG8 causes ALG8-CDG (CDG-1h)
Sialic acid metabolism
Defective MPDU1 causes MPDU1-CDG (CDG-1f)
Defective ALG12 causes ALG12-CDG (CDG-1g)
Diseases associated with N-glycosylation of proteins
Drugs
Diseases
GWAS
Protein-Protein Interactions
17 interactors:
ADAMTSL4
CRMP1
GTPBP3
KIAA1549
KRT31
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP4-12
KRTAP5-9
KRTAP9-2
NOTCH2NL
RIF1
SPRY2
ZBTB16
108 interactors:
ADAMTSL4
AEN
ALDH3B1
AMOTL2
BCL6B
BMP7
BYSL
C11orf87
C19orf66
C9orf9
CARD9
CHRD
CNNM3
CREB5
DHX57
ECE1
EIF4E2
ENKD1
FAM74A4
FAM76B
FARS2
GATA1
GLIDR
GLRX3
GNE
GOLGA8EP
HHEX
HOXA1
HPCAL1
KRTAP10-3
KRTAP10-7
KRTAP12-1
KRTAP12-2
KRTAP2-4
KRTAP26-1
KRTAP3-2
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LCE1B
LCE2A
LCE2D
LCE3C
LCE3E
LCE4A
LIMS2
LUZP4
MEOX2
MOBP
MT1DP
MXI1
NAA10
NOTCH2NL
NPDC1
NR4A1
NUFIP2
OTX1
POM121L8P
PRKAB2
PRR13
PVRL2
SCNM1
SLC23A1
SLC6A20
SMCP
SPATA3
SPRY1
SPRY2
STK16
TBC1D16
THAP10
TNP2
TNS2
TRPV6
TULP3
TXNDC5
TYMSOS
UTP23
WDYHV1
WT1-AS
ZBTB24
ZBTB48
ZFYVE21
ZNF20
ZNF264
ZNF273
ZNF286A
ZNF32
ZNF320
ZNF329
ZNF34
ZNF417
ZNF433
ZNF439
ZNF559
ZNF572
ZNF587
ZNF670
ZNF679
ZNF697
ZNF707
ZNF785
ZNF792
ZSCAN21
ZSCAN26
Entrez ID
10020
386680
HPRD ID
04825
11191
Ensembl ID
ENSG00000159921
Uniprot IDs
H0YFA7
Q9Y223
P60370
PDB IDs
2YHW
2YHY
2YI1
3EO3
Enriched GO Terms of Interacting Partners
?
Transcription, DNA-templated
RNA Metabolic Process
RNA Biosynthetic Process
Gene Expression
Cellular Macromolecule Biosynthetic Process
Macromolecule Biosynthetic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Cellular Aromatic Compound Metabolic Process
Regulation Of Transcription, DNA-templated
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Nitrogen Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Biosynthetic Process
Keratinization
Regulation Of Nitrogen Compound Metabolic Process
Keratinocyte Differentiation
Regulation Of Metabolic Process
Epidermal Cell Differentiation
Epithelium Development
Epidermis Development
Cellular Process
Cellular Metabolic Process
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Skin Development
Tissue Development
Regulation Of Cellular Process
Negative Regulation Of Smoothened Signaling Pathway Involved In Ventral Spinal Cord Patterning
Organ Development
Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Chordate Embryonic Development
Embryo Development Ending In Birth Or Egg Hatching
Embryonic Neurocranium Morphogenesis
Penetration Of Zona Pellucida
Embryo Development
Epithelial Cell Differentiation
Epithelial Tube Branching Involved In Lung Morphogenesis
Bud Elongation Involved In Lung Branching
Pattern Specification Process
Embryonic Organ Development
Negative Regulation Of Protein Serine/threonine Kinase Activity
Embryonic Morphogenesis
Lung Morphogenesis
Anterior/posterior Pattern Specification
Respiratory Tube Development
Negative Regulation Of Ras GTPase Activity
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Tagcloud
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Difference)
?
15s
alphap
competition
contaminant
doublet
eif2
eif2alpha
eif2b
exchange
gdp
germ
gtp
guanine
heme
impairs
inability
insects
interact
lysates
nucleotides
p41
presumably
residue
reticulocyte
unable
unlike
wg
wheat
x
Tagcloud (Intersection)
?