KRTAP5-9 and COMT

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KRTAP5-9	COMT
Gene Name		keratin associated protein 5-9	catechol-O-methyltransferase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Keratin Filament	Mitochondrion Cytosol Plasma Membrane Membrane Integral Component Of Membrane Axon Dendritic Spine Cell Body Postsynaptic Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Magnesium Ion Binding Protein Binding O-methyltransferase Activity Catechol O-methyltransferase Activity
	Biological Process	Epidermis Development	Xenobiotic Metabolic Process Synaptic Transmission Female Pregnancy Learning Short-term Memory Estrogen Metabolic Process Response To Organic Cyclic Compound Cellular Response To Phosphate Starvation Methylation Response To Lipopolysaccharide Developmental Process Negative Regulation Of Renal Sodium Excretion Neurotransmitter Catabolic Process Neurotransmitter Biosynthetic Process Dopamine Catabolic Process Response To Drug Small Molecule Metabolic Process Negative Regulation Of Dopamine Metabolic Process Response To Pain Multicellular Organismal Reproductive Process Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Homocysteine Metabolic Process Regulation Of Sensory Perception Of Pain
Pathways			Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Dopamine clearance from the synaptic cleft Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Neurotransmitter Clearance In The Synaptic Cleft Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) Transmission across Chemical Synapses
Drugs			S-Adenosylmethionine Tolcapone Entacapone 3,5-Dinitrocatechol BIA N-{3-[5-(6-Amino-Purin-9-Yl)-3,4-Dihydroxy-Tetrahydro-Furan-2-Yl]-Allyl}-2,3-Dihydroxy-5-Nitro-Benzamide Nialamide (3,4-DIHYDROXY-2-NITROPHENYL)(PHENYL)METHANONE 7,8-dihydroxy-4-phenyl-2H-chromen-2-one
Diseases
GWAS
Protein-Protein Interactions		103 interactors: ADAMTSL4 ALPP ATG9A BEX2 BMP7 C10orf62 C11orf87 C19orf66 CARKD CATSPER1 CHIC2 CHRD CKS1B CNNM3 COMT CRCT1 CTSZ CXCL16 DHRS1 DMRT3 DOCK2 FAH FAM124B FAM161A FAM74A4 FAM76B GLRX3 GNE HOXA1 HOXB9 HPCAL1 HSPD1 JOSD1 KLHL38 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-1 KRTAP12-2 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP9-2 KRTAP9-4 LCE1B LCE2A LCE3C LCE3E LCE4A LY6H MAPKBP1 MEOX2 NCLN NLK NMU NOTCH2NL NPBWR2 NPDC1 NTM NTN4 NUFIP2 OTX1 P2RX4 PCSK5 PFKL PGLS POM121L8P PRKAB2 PSMA1 PTPMT1 PVRL2 RAMP3 RGS20 RNF111 SCARB1 SDC3 SDCBP SLC22A23 SLC25A10 SMCP SPINK2 SPRY2 TBC1D10C TBC1D16 TCEA2 TCEANC TOMM22 TYRO3 WDYHV1 YIPF3 ZBTB24 ZFYVE21 ZNF124 ZNF266 ZNF417 ZNF439 ZNF581 ZNF587	10 interactors: ACE CDC27 KRT31 KRT40 KRTAP5-9 LITAF RGS2 TRIP13 VKORC1 XRN2
Entrez ID		3846	1312
HPRD ID		01008	00284
Ensembl ID		ENSG00000254997	ENSG00000093010
Uniprot IDs		P26371	P21964
PDB IDs			3A7E 3BWM 3BWY
Enriched GO Terms of Interacting Partners?		Keratinization Keratinocyte Differentiation Pattern Specification Process Epidermal Cell Differentiation Developmental Process Positive Regulation Of Immune Response To Tumor Cell Adhesion Of Symbiont To Host Locomotion Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Muscle Hypertrophy Organ Development Cell Recognition Skin Development Multicellular Organismal Development Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Anterior/posterior Pattern Specification Cell Differentiation System Development Epidermis Development Transcription, DNA-templated	Spermatogenesis Male Gamete Generation Gamete Generation Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Reproduction Negative Regulation Of Gap Junction Assembly Cell Proliferation In Bone Marrow Single Organism Reproductive Process Positive Regulation Of Peptidyl-cysteine S-nitrosylation Developmental Process Reproductive Process Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Renal Output By Angiotensin Angiotensin Catabolic Process In Blood Multicellular Organismal Protein Catabolic Process Multicellular Organismal Protein Metabolic Process Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Hematopoietic Stem Cell Proliferation Vitamin K Metabolic Process Positive Regulation Of Cardiac Muscle Contraction Negative Regulation Of CAMP-mediated Signaling Hormone Catabolic Process Negative Regulation Of Phospholipase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Angiotensin Maturation Epidermis Development Regulation Of Angiotensin Metabolic Process Peptide Catabolic Process Regulation Of Blood Volume By Renin-angiotensin Hematopoietic Stem Cell Differentiation Arachidonic Acid Secretion Positive Regulation Of Microtubule Polymerization Peptidyl-glutamic Acid Carboxylation Relaxation Of Cardiac Muscle Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Negative Regulation Of Transferase Activity Female Meiosis I Negative Regulation Of NF-kappaB Import Into Nucleus Negative Regulation Of Smooth Muscle Contraction Blood Circulation Positive Regulation Of Protein Autophosphorylation Negative Regulation Of Lipase Activity Neutrophil Mediated Immunity
Tagcloud ?			3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity
Tagcloud (Difference) ?			3h altering alters c6 catechol catecholamines dopamine fourfold hek293 heterologous hplc kinetic km metabolizes monoamine neurotransmitter norepinephrine plasmalemmal potencies retention ro saturation serotonin substrates transporter transporters tropolone uptake velocity
Tagcloud (Intersection) ?