HDAC5 and NCOR1

Number of citations of the paper that reports this interaction (PMID 10640275)
92

Data Source:
HPRD (in vitro, two hybrid)

		HDAC5	NCOR1
Gene Name		histone deacetylase 5	nuclear receptor corepressor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body	Histone Deacetylase Complex Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Spindle Microtubule Membrane Sin3 Complex Transcriptional Repressor Complex
	Molecular Function	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	RNA Polymerase II Activating Transcription Factor Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Histone Deacetylase Regulator Activity Nuclear Hormone Receptor Binding Histone Deacetylase Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Development Chromatin Organization Chromatin Remodeling Chromatin Silencing Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Chromatin Modification Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Multicellular Organismal Response To Stress Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Response To Drug Regulation Of Protein Binding Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Negative Regulation Of Transcription From RNA Polymerase II Promoter CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Chromatin Organization Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transforming Growth Factor Beta Receptor Signaling Pathway Notch Signaling Pathway Circadian Rhythm Gene Expression Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Chromatin Modification Thalamus Development Positive Regulation Of Histone Deacetylation Circadian Regulation Of Gene Expression Regulation Of Multicellular Organism Growth Cholesterol Homeostasis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Negative Regulation Of JNK Cascade Spindle Assembly Definitive Erythrocyte Differentiation Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Fatty Acid Transport
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer	Loss of Function of TGFBR2 in Cancer PPARA activates gene expression Signaling by NOTCH1 HD Domain Mutants in Cancer Organelle biogenesis and maintenance Metabolism of lipids and lipoproteins Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer SMAD2/3 MH2 Domain Mutants in Cancer TGFBR1 LBD Mutants in Cancer Downregulation of SMAD2/3:SMAD4 transcriptional activity RORA activates circadian gene expression Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer Fatty acid, triacylglycerol, and ketone body metabolism SMAD2/3 Phosphorylation Motif Mutants in Cancer Chromatin organization HDACs deacetylate histones Loss of Function of SMAD2/3 in Cancer Signaling by NOTCH TGFBR2 Kinase Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer REV-ERBA represses gene expression Signaling by ERBB4 Loss of Function of TGFBR1 in Cancer Mitochondrial biogenesis NOTCH1 Intracellular Domain Regulates Transcription Nuclear signaling by ERBB4 Chromatin modifying enzymes Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex Signaling by NOTCH1 PEST Domain Mutants in Cancer Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Constitutive Signaling by NOTCH1 PEST Domain Mutants SMAD4 MH2 Domain Mutants in Cancer
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		59 interactors: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	85 interactors: ACTN2 AR ATXN1 ATXN1L ATXN3 BAZ1A BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ESR1 ESR2 ETS1 ETS2 GPS2 GTF2B HDAC3 HDAC5 HDAC9 HESX1 HEY2 HIST1H3A HIST1H4A HTT MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 PDCD2 PHB PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRB TXNRD2 VDR ZBTB16 ZBTB33 ZMYND11
Entrez ID		10014	9611
HPRD ID		09246	02911
Ensembl ID		ENSG00000108840	ENSG00000141027
Uniprot IDs		Q9UQL6	O75376 Q6PGR4
PDB IDs			2EQR 3H52 3KMZ 3N00 4II6
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process System Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process Anatomical Structure Development Cell Differentiation Regulation Of Cell Death Multicellular Organismal Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Deacetylation	Transcription, DNA-templated RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process Gene Expression Regulation Of Nucleic Acid-templated Transcription RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Intracellular Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Negative Regulation Of Cellular Metabolic Process DNA-templated Transcription, Initiation Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Cellular Metabolic Process Hormone-mediated Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Metabolic Process Cellular Metabolic Process Response To Steroid Hormone Cellular Response To Organic Substance Cellular Response To Lipid Regulation Of Cell Differentiation Cellular Response To Hormone Stimulus Cellular Response To Organic Cyclic Compound Regulation Of Cellular Process Response To Organic Substance
Tagcloud ?		125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis	acted actively anterior depleted dispensable embryogenesis hemangioblasts knocking lmo2 mfap4 morphants morpholino mpx myelopoiesis ncor2 neutrophils overexpressing precursors primitive repress repressors rescue specification spi1b substituted tal1 technologies vertebrate zebrafish
Tagcloud (Difference) ?		125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis	acted actively anterior depleted dispensable embryogenesis hemangioblasts knocking lmo2 mfap4 morphants morpholino mpx myelopoiesis ncor2 neutrophils overexpressing precursors primitive repress repressors rescue specification spi1b substituted tal1 technologies vertebrate zebrafish
Tagcloud (Intersection) ?