HDAC5 and RFXANK

Number of citations of the paper that reports this interaction (PubMedID 15964851)
0

Data Source:
HPRD (in vitro, in vivo)

		HDAC5	RFXANK
Description		histone deacetylase 5	regulatory factor X associated ankyrin containing protein
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Protein-containing Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Intercellular Bridge RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity Transcription Corepressor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Protein Lysine Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Inflammatory Response Response To Xenobiotic Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Response To Cocaine Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Ras Protein Signal Transduction Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases			Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency Bare lymphocyte syndrome (BLS) type2
GWAS		Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 31043756 33263727 34002096) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Mean platelet volume ( 32888494)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Refractive error ( 32231278)
Interacting Genes		60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE ZBTB16	6 interacting genes: CIITA HDAC4 HDAC5 RAF1 RFX5 RFXAP
Entrez ID		10014	8625
HPRD ID		09246	04435
Ensembl ID		ENSG00000108840	ENSG00000064490
Uniprot IDs		Q9UQL6	A0A024R7P0 O14593
PDB IDs		5UWI 8Q9P	3UXG 3V30 6MEW
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Binding Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Transcription Coregulator Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Sequence-specific Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Histone Deacetylase Complex Regulation Of MiRNA Transcription Regulation Of Nucleocytoplasmic Transport	Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Interferon-mediated Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Histone Deacetylase Activity, Hydrolytic Mechanism Positive Regulation Of RNA Metabolic Process Protein Lysine Deacetylase Activity Type II Interferon-mediated Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity DNA-binding Transcription Factor Binding DNA-binding Transcription Activator Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Negative Regulation Of Muscle Cell Differentiation Regulation Of RNA Metabolic Process Lipid Localization Cytokine-mediated Signaling Pathway Nuclear Speck Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Striated Muscle Cell Differentiation Lymphocyte Activation Death-inducing Signaling Complex Assembly Stress-induced Mitochondrial Fusion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process B Cell Differentiation Leukocyte Activation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of RNA Metabolic Process Regulation Of Muscle Cell Differentiation Cell Activation Negative Regulation Of Nucleobase-containing Compound Metabolic Process
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