HDAC5 and ANKRA2

Number of citations of the paper that reports this interaction (PMID 15964851)
5

Data Source:
BioGRID (unspecified method)
HPRD (in vitro, in vivo)

		HDAC5	ANKRA2
Gene Name		histone deacetylase 5	ankyrin repeat, family A (RFXANK-like), 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Body	Nucleus Cytosol Cytoskeleton Membrane
	Molecular Function	Core Promoter Binding Transcription Corepressor Activity Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD-dependent Histone Deacetylase Activity (H4-K16 Specific) Repressing Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K18 Specific)	Transcription Cofactor Activity Low-density Lipoprotein Particle Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Osteoblast Development Chromatin Organization Chromatin Remodeling Chromatin Silencing Transcription, DNA-templated Inflammatory Response Notch Signaling Pathway Heart Development Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Chromatin Modification Histone Deacetylation B Cell Differentiation Cellular Response To Insulin Stimulus Multicellular Organismal Response To Stress Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Response To Drug Regulation Of Protein Binding Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Histone H3-K9 Modification Histone H3 Deacetylation Histone H4 Deacetylation Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Regulation Of Transcription From RNA Polymerase II Promoter Biological_process
Pathways		Signaling by NOTCH1 HD Domain Mutants in Cancer Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Signaling by NOTCH Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant NOTCH1 Intracellular Domain Regulates Transcription Signaling by NOTCH1 Signaling by NOTCH1 PEST Domain Mutants in Cancer Signaling by NOTCH1 in Cancer Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Constitutive Signaling by NOTCH1 PEST Domain Mutants FBXW7 Mutants and NOTCH1 in Cancer
Drugs
Diseases
GWAS		Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982)
Protein-Protein Interactions		59 interactors: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	10 interactors: ABL1 APP HDAC4 HDAC5 HDAC9 LRP2 MPL NEK6 PDE3B RFX5
Entrez ID		10014	57763
HPRD ID		09246	12044
Ensembl ID		ENSG00000108840	ENSG00000164331
Uniprot IDs		Q9UQL6	Q9H9E1
PDB IDs			3SO8 3V2O 3V2X 3V31 4LG6
Enriched GO Terms of Interacting Partners?		Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of RNA Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Transcription, DNA-templated Negative Regulation Of RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Biosynthetic Process Negative Regulation Of Gene Expression Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Regulation Of Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Positive Regulation Of Metabolic Process Organ Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Cellular Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process System Development Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Developmental Process Anatomical Structure Development Cell Differentiation Regulation Of Cell Death Multicellular Organismal Development Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Apoptotic Process Positive Regulation Of Cell Death Positive Regulation Of Protein Deacetylation	Regulation Of Skeletal Muscle Fiber Development B Cell Differentiation Cell Activation Histone H4 Deacetylation Regulation Of Muscle Cell Differentiation Histone H3 Deacetylation B Cell Activation Histone H3-K9 Modification Regulation Of Myotube Differentiation Collateral Sprouting Regulation Of Skeletal Muscle Tissue Development Lymphocyte Differentiation Histone Deacetylation Protein Deacetylation Peptidyl-lysine Deacetylation Regulation Of Striated Muscle Cell Differentiation Response To Stress Leukocyte Differentiation Signal Transduction Negative Regulation Of Myotube Differentiation Lymphocyte Activation Regulation Of Cell Migration Involved In Sprouting Angiogenesis Blood Coagulation Regulation Of Striated Muscle Tissue Development Signaling Hemostasis Cell Communication Regulation Of Sprouting Angiogenesis Notch Signaling Pathway Regulation Of Protein Binding Cellular Response To Organonitrogen Compound Negative Regulation Of Striated Muscle Cell Differentiation Leukocyte Activation Organ Development Osteoblast Development Regulation Of Cellular Senescence Regulation Of Body Fluid Levels Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process Wound Healing Cellular Response To Stimulus Cellular Response To Insulin Stimulus Hemopoiesis Regulation Of Angiogenesis Defense Response Response To Wounding Immune System Development Regulation Of Binding Negative Regulation Of Muscle Cell Differentiation Negative Regulation Of Osteoblast Differentiation
Tagcloud ?		125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis	ankyrin deacetylases docking hdac4 hdac5 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover
Tagcloud (Difference) ?		125a 5p activating anticancer apoptosis converse deacetylase detailed doi downregulation exist hdaci implications induce intrinsic involving loop mediates microrna mir mt nevertheless runx3 silenced silencing subsequently transcriptionally tumorigenesis	ankyrin deacetylases docking hdac4 hdac9 iia lock megalin motif operate paralog preference principle proteome pxlpxi recognize recognizes repeat repeats residue rfx5 rfxank sequester serving switch tumbler uncharacterized uncover
Tagcloud (Intersection) ?		hdac5