HDAC5 and GCM1

Number of citations of the paper that reports this interaction (PubMedID 16528103)
21

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HDAC5	GCM1
Description		histone deacetylase 5	glial cells missing transcription factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Protein-containing Complex	Chromatin Nucleus Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity Transcription Corepressor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Protein Lysine Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Inflammatory Response Response To Xenobiotic Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Response To Cocaine Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Syncytium Formation By Plasma Membrane Fusion Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Gliogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Fate Commitment Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Branching Involved In Labyrinthine Layer Morphogenesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 31043756 33263727 34002096) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Mean platelet volume ( 32888494)	Cerebrospinal fluid AB1-42 levels ( 26252872)
Interacting Genes		60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE ZBTB16	9 interacting genes: CAMK1 CREBBP DUSP23 HDAC1 HDAC3 HDAC4 HDAC5 SENP1 UBE2I
Entrez ID		10014	8521
HPRD ID		09246	04757
Ensembl ID		ENSG00000108840	ENSG00000137270
Uniprot IDs		Q9UQL6	Q9NP62
PDB IDs		5UWI 8Q9P
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Binding Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Transcription Coregulator Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Sequence-specific Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Histone Deacetylase Complex Regulation Of MiRNA Transcription Regulation Of Nucleocytoplasmic Transport	Histone Deacetylase Activity, Hydrolytic Mechanism Protein Lysine Deacetylase Activity Negative Regulation Of Myotube Differentiation Histone Deacetylase Activity Negative Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Complex Regulation Of Myotube Differentiation Regulation Of Muscle Cell Differentiation DNA-binding Transcription Factor Binding Protein Deacetylation Negative Regulation Of Muscle Cell Differentiation Regulation Of Striated Muscle Cell Differentiation Macromolecule Deacylation Histone Deacetylase Binding Protein Lysine Delactylase Activity Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression, Epigenetic Protein Decrotonylase Activity Histone Decrotonylase Activity Transcription Corepressor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein Sumoylation Negative Regulation Of Transcription By RNA Polymerase II Protein Modification Process Regulation Of Transcription By RNA Polymerase II Transcription Repressor Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Epigenetic Regulation Of Gene Expression Chromatin Remodeling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Chromatin Organization SUMO Transferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation DNA-binding Transcription Activator Activity Hydrolase Activity Chromatin Binding Presynaptic Cytosol Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process
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