HDAC5 and NRIP1

Number of citations of the paper that reports this interaction (PubMedID 15060175)
53

Data Source:
BioGRID (two hybrid)
HPRD (in vitro, in vivo)

		HDAC5	NRIP1
Description		histone deacetylase 5	nuclear receptor interacting protein 1
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Protein-containing Complex	Histone Deacetylase Complex Chromatin Fibrillar Center Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Speck
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity Transcription Corepressor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Protein Lysine Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity Transcription Corepressor Activity Signaling Receptor Binding Protein Binding Nuclear Receptor Binding Nuclear Estrogen Receptor Binding Nuclear Glucocorticoid Receptor Binding Histone Deacetylase Binding Nuclear Retinoic Acid Receptor Binding Nuclear Retinoid X Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Inflammatory Response Response To Xenobiotic Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Response To Cocaine Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Negative Regulation Of Transcription By RNA Polymerase II Ovarian Follicle Rupture Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Lipid Storage Ovulation Circadian Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Cellular Response To Estradiol Stimulus
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription	SUMOylation of transcription cofactors Estrogen-dependent gene expression NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide	4-HYDROXY-N'-(4-ISOPROPYLBENZYL)BENZOHYDRAZIDE
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 31043756 33263727 34002096) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Mean platelet volume ( 32888494)	Alcohol dependence ( 26365420) Birth weight ( 27680694 31043758) Blood urea nitrogen levels ( 31152163) Breast cancer ( 23535729 29059683) Chronic kidney disease ( 31152163) Cognitive performance ( 19734545) Crohn's disease ( 25489960) Depression in smokers ( 30219690) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Estimated glomerular filtration rate ( 31152163 31451708 30604766 31015462) Estimated glomerular filtration rate in non-diabetics ( 31451708) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494) Hemoglobin ( 32888494) Lymphocyte count ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494) Plateletcrit ( 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) White blood cell count ( 32888494)
Interacting Genes		60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE ZBTB16	124 interacting genes: ACBD3 ACTN2 AGR2 AHR AKAP6 ANKRD24 APP AR ARPC3 BAIAP2 BRCA1 CCDC85B CDK8 CEP70 CIB1 CLPB COG4 CREBZF CRNKL1 CTBP1 CTBP2 DNMT1 DNMT3A DNMT3B DST DYNC2I1 E2F1 ERC2 ESR1 ESR2 ESRRA ESRRB ESRRG EXOC7 FEZ1 FMNL2 GPRASP3 GPSM2 HDAC1 HDAC2 HDAC3 HDAC5 HDAC9 HECTD1 HNF4A HSPA5 HUWE1 IMMT IPO5 IQGAP1 JAKMIP3 JUN KALRN KANK2 KAT2B KDM5B KIF3A KIF5A KLHL7 KPNA3 KPNA4 LDOC1 LRRCC1 MACF1 MAP3K7 MAPK8IP3 MLLT3 MTMR10 NCKAP5 NR0B1 NR1H2 NR1H3 NR2C1 NR3C1 NR5A1 NR5A2 NSUN2 OAZ1 ODF2 PIAS1 PIAS3 PKNOX1 PKNOX2 PLAAT3 PLK2 PPARA PPARD PPARG PRMT1 PSMD1 RABEP1 RARA RARB RORB RXRA RXRB RXRG SCG2 SCG3 SESTD1 SF3B1 SHTN1 SNX1 SPTB SPTBN1 TERF1 TEX11 THRA THRB TMEM131 TNFRSF14 TRAF2 TRIM8 TRIM9 TRIP12 TTLL5 TULP3 TXLNG TXNDC11 UBE2I VDR YWHAH ZNF365 ZNF821
Entrez ID		10014	8204
HPRD ID		09246	03927
Ensembl ID		ENSG00000108840	ENSG00000180530
Uniprot IDs		Q9UQL6	A8K171 P48552
PDB IDs		5UWI 8Q9P	2GPO 2GPP 4S14 4S15 5NTI 5NTN 5NTW 5NU1 6FZU 6G05 6G07 9CWN
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Binding Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Transcription Coregulator Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Sequence-specific Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Histone Deacetylase Complex Regulation Of MiRNA Transcription Regulation Of Nucleocytoplasmic Transport	Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Nuclear Steroid Receptor Activity Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Negative Regulation Of RNA Metabolic Process Sequence-specific DNA Binding Retinoic Acid Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Intracellular Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Nucleoplasm Estrogen Response Element Binding Transcription Coregulator Binding Sequence-specific Double-stranded DNA Binding Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Developmental Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasm Nucleus Negative Regulation Of Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Metabolic Process
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