HDAC5 and ANKRD11

Number of citations of the paper that reports this interaction (PubMedID 15184363)
0

Data Source:
HPRD (in vitro)

		HDAC5	ANKRD11
Description		histone deacetylase 5	ankyrin repeat domain containing 11
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck Protein-containing Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity Transcription Corepressor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Hydrolase Activity Protein Lysine Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding Histone Deacetylase Activity, Hydrolytic Mechanism
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Inflammatory Response Response To Xenobiotic Stimulus Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Epigenetic Regulation Of Gene Expression B Cell Activation Response To Cocaine Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Odontogenesis Of Dentin-containing Tooth Skeletal System Morphogenesis Head Morphogenesis Face Development Face Morphogenesis
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs		Valproic acid Decitabine Vorinostat Belinostat Romidepsin Panobinostat Phenylbutyric acid Entinostat Abexinostat Givinostat Pyroxamide
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 31043756 33263727 34002096) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 28869591 30598549) Mean platelet volume ( 32888494)	Eosinophil count ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 27863252 32888494) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE ZBTB16	92 interacting genes: ABHD11 AGR2 ANKRD33 ARID3A ARID5A BRCC3 C18orf54 C1QTNF2 CALCA CCDC196 CCHCR1 CCN3 CDC23 CDCA7L CDR2L CEP44 CFAP68 COG4 DEPTOR FAM136A FAM221B FOLR3 FTO GOLGA2 GOLGA6L9 GPRASP3 GRIPAP1 HAUS3 HDAC3 HDAC4 HDAC5 HOMEZ HOOK2 HRAS IGFBP6 IKZF1 ITGB3BP KANK2 KRT34 LZTS2 MECOM MKRN3 MTFR1L MTUS2 MXRA8 MYF5 NAB2 NCOA1 NCOA2 NCOA3 NOTO NTAQ1 PDE4DIP PIH1D2 PLAGL2 PPARA RAC3 RCOR3 RINT1 RPH3AL RSPO4 RUBCN SERTAD3 SNRNP35 SPANXN2 SPATA2 SPMIP5 SPRY1 SRC STMN3 STRA8 SYTL3 TADA2B TFIP11 TLE5 TNNI1 TRAF2 TRIM37 TRIM54 TSPOAP1 TTC23L TXN UFC1 USH1G USP54 USP6 VDR VHL ZNF426 ZNF552 ZNF655 ZNF688
Entrez ID		10014	29123
HPRD ID		09246	12456
Ensembl ID		ENSG00000108840	ENSG00000167522
Uniprot IDs		Q9UQL6	Q6UB99
PDB IDs		5UWI 8Q9P
Enriched GO Terms of Interacting Partners?		Histone Deacetylase Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of Primary Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Repressor Complex Positive Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Chromatin DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Corepressor Binding Chromatin Binding Negative Regulation Of Macromolecule Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Metabolic Process Transcription Coregulator Binding DNA Binding Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Developmental Process Positive Regulation Of Nucleocytoplasmic Transport Sequence-specific Double-stranded DNA Binding Intracellular Signal Transduction Positive Regulation Of Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Histone Deacetylase Complex Regulation Of MiRNA Transcription Regulation Of Nucleocytoplasmic Transport	Protein Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Complex Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Myotube Differentiation Regulation Of Myotube Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Striated Muscle Cell Differentiation Histone Deacetylase Activity, Hydrolytic Mechanism Nuclear Receptor-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Muscle Cell Differentiation Protein Lysine Deacetylase Activity Cellular Response To Thyroglobulin Triiodothyronine Nuclear Retinoid X Receptor Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Centrosome Cycle Histone Deacetylase Activity Vitamin D Receptor Signaling Pathway Regulation Of Muscle Cell Differentiation Protein Deubiquitination DNA-binding Transcription Activator Activity Response To Thyroglobulin Triiodothyronine Regulation Of Primary Metabolic Process Protein Modification By Small Protein Removal
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