VPS35 and VEGFA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		VPS35	VEGFA
Gene Name		vacuolar protein sorting 35 homolog (S. cerevisiae)	vascular endothelial growth factor A
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Retromer Complex Extracellular Vesicular Exosome Tubular Endosome	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Cytoplasm Cell Surface Membrane Secretory Granule Platelet Alpha Granule Lumen
	Molecular Function	Protein Binding Protein Transporter Activity	Fibronectin Binding Cytokine Activity Platelet-derived Growth Factor Receptor Binding Vascular Endothelial Growth Factor Receptor Binding Protein Binding Growth Factor Activity Heparin Binding Neuropilin Binding Chemoattractant Activity Identical Protein Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 1 Binding Vascular Endothelial Growth Factor Receptor 2 Binding Protein Heterodimerization Activity Receptor Agonist Activity Extracellular Matrix Binding
	Biological Process	Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Transcytosis Negative Regulation Of Late Endosome To Lysosome Transport Retrograde Transport, Endosome To Plasma Membrane	Negative Regulation Of Transcription From RNA Polymerase II Promoter Angiogenesis Ovarian Follicle Development Patterning Of Blood Vessels Vasculogenesis Response To Hypoxia In Utero Embryonic Development Kidney Development Positive Regulation Of Protein Phosphorylation Positive Regulation Of Endothelial Cell Proliferation Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Neuroblast Proliferation Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Receptor Internalization Basophil Chemotaxis Platelet Degranulation Positive Regulation Of Leukocyte Migration Heart Morphogenesis Outflow Tract Morphogenesis Coronary Vein Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter Nervous System Development Mesoderm Development Lactation Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Cell Shape Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Platelet Activation Monocyte Differentiation Macrophage Differentiation Lung Development Positive Regulation Of Cell Migration Regulation Of CGMP Metabolic Process Epithelial Cell Differentiation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Post-embryonic Camera-type Eye Development Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Autophosphorylation Activation Of Protein Kinase Activity Positive Regulation Of CREB Transcription Factor Activity Positive Regulation Of Peptidyl-serine Phosphorylation Tube Formation Endothelial Cell Chemotaxis Cellular Response To Vascular Endothelial Growth Factor Stimulus Lymph Vessel Morphogenesis Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway VEGF-activated Neuropilin Signaling Pathway Growth Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Positive Regulation Of Vascular Permeability Surfactant Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Maturation Camera-type Eye Morphogenesis Cardiac Muscle Fiber Development Branching Morphogenesis Of An Epithelial Tube Positive Regulation Of Axon Extension Involved In Axon Guidance Artery Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Chemotaxis Positive Regulation Of Positive Chemotaxis Induction Of Positive Chemotaxis Positive Regulation Of Cellular Component Movement Positive Regulation Of Cell Division Positive Regulation Of Focal Adhesion Assembly Primitive Erythrocyte Differentiation Mammary Gland Alveolus Development Positive Regulation Of Mast Cell Chemotaxis Cardiac Vascular Smooth Muscle Cell Development Coronary Artery Morphogenesis Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Hypoxia Dopaminergic Neuron Differentiation Commissural Neuron Axon Guidance Positive Regulation Of Protein Kinase C Signaling Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of P38MAPK Cascade Positive Regulation Of Histone Deacetylase Activity Positive Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Kinase D Signaling
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking	VEGF binds to VEGFR leading to receptor dimerization Cellular response to hypoxia VEGF ligand-receptor interactions Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by VEGF Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation Regulation of gene expression by Hypoxia-inducible Factor
Drugs			Bevacizumab Minocycline Gliclazide Carvedilol Ranibizumab Pyroglutamic Acid Tris(Hydroxymethyl)Aminomethane Vandetanib Dalteparin Aflibercept
Diseases
GWAS			Adiponectin levels ( 22479202) Age-related macular degeneration ( 23455636 21665990) Chronic kidney disease ( 20383146) Coronary heart disease ( 22319020) Thyroid hormone levels ( 23408906) Type 2 diabetes ( 18372903) Urate levels ( 23263486) Waist-hip ratio ( 20935629)
Protein-Protein Interactions		9 interactors: APP FAM21C MTNR1B SNX1 SNX3 VEGFA VPS26B VPS29 ZNF512B	25 interactors: ADAMTS1 AKT1 CRYAB CTGF ELAVL1 EPHB2 FLT1 GPC1 HNRNPD IGFBP7 KDR LYVE1 NRP1 NRP2 PGF PRRG4 SEMA3F SPARC TNXB U2AF1 VEGFB VPS35 VTN YBX1 YBX3
Entrez ID		55737	7422
HPRD ID		06085	01889
Ensembl ID			ENSG00000112715
Uniprot IDs		Q96QK1	A2A2V4 P15692
PDB IDs		2R17	1BJ1 1CZ8 1FLT 1KAT 1KMX 1MJV 1MKG 1MKK 1QTY 1TZH 1TZI 1VGH 1VPF 1VPP 2FJG 2FJH 2QR0 2VGH 2VPF 3BDY 3P9W 3QTK 3S1B 3S1K 3V2A 4DEQ 4GLN 4GLS
Enriched GO Terms of Interacting Partners?		Retrograde Transport, Endosome To Golgi Vesicle-mediated Transport Endosomal Transport Establishment Of Localization In Cell Cellular Localization Intracellular Transport Retrograde Transport, Endosome To Plasma Membrane Regulation Of Cell Development Platelet Degranulation Positive Regulation Of Protein Kinase D Signaling Basophil Chemotaxis Intralumenal Vesicle Formation Transport Positive Regulation Of Protein Localization To Early Endosome Synaptic Growth At Neuromuscular Junction Negative Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Vein Morphogenesis Primitive Erythrocyte Differentiation VEGF-activated Neuropilin Signaling Pathway Regulation Of Receptor Activity Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Barbed-end Actin Filament Capping Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Deacetylase Activity Protein Transport Cell Maturation Establishment Of Protein Localization Positive Regulation Of Lymphangiogenesis Cardiac Vascular Smooth Muscle Cell Development Positive Regulation Of Mast Cell Chemotaxis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Lamellipodium Morphogenesis Collateral Sprouting Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Axon Midline Choice Point Recognition Regulation Of Histone Deacetylase Activity Regulation Of Neurogenesis Regulation Of Endocytosis Positive Regulation Of Deacetylase Activity Coronary Artery Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Platelet Activation Regulation Of Cell-substrate Adhesion	Regulation Of Endothelial Cell Proliferation Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Endothelial Cell Proliferation Cardiovascular System Development Angiogenesis Positive Regulation Of Cell Migration Blood Vessel Development Positive Regulation Of Cell Motility Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cellular Component Movement Vasculature Development Positive Regulation Of Locomotion Multicellular Organismal Development Anatomical Structure Formation Involved In Morphogenesis Developmental Process Positive Regulation Of Endothelial Cell Migration Anatomical Structure Development Blood Vessel Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Epithelial Cell Proliferation Regulation Of Locomotion Anatomical Structure Morphogenesis Sympathetic Neuron Projection Extension Sympathetic Neuron Projection Guidance Ventral Trunk Neural Crest Cell Migration Regulation Of Cellular Component Movement Positive Regulation Of Epithelial Cell Migration Cellular Response To Vascular Endothelial Growth Factor Stimulus Neural Crest Cell Migration Involved In Autonomic Nervous System Development Semaphorin-plexin Signaling Pathway Involved In Neuron Projection Guidance Axon Extension Involved In Axon Guidance Regulation Of Endothelial Cell Migration Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Cell Proliferation Regulation Of Cell Migration Embryo Development Sympathetic Ganglion Development Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Motility Facial Nerve Structural Organization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Facial Nerve Morphogenesis Organ Development Regulation Of MRNA Stability System Development Cranial Nerve Development Regulation Of RNA Stability Sprouting Angiogenesis
Tagcloud ?		allosteric biophysical cargo consists deciphered disrupts endosomal endosomes fret golgi gtpase hela insights instrumental nexins perturbed rab7 recognizing recruit recruitment recruits recycle retromer snx sorting sub vacuolar vps26	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups wiley
Tagcloud (Difference) ?		allosteric biophysical cargo consists deciphered disrupts endosomal endosomes fret golgi gtpase hela insights instrumental nexins perturbed rab7 recognizing recruit recruitment recruits recycle retromer snx sorting sub vacuolar vps26	autophagy bcl2 birc5 buffer constituents damaged dataset degrades deregulation distant eif4ebp1 ero1l fos gapdh gse21653 gse3494 gse7390 inc itpr1 lived organelles periodicals prognostic proportional shortened signature starvation subgroups wiley
Tagcloud (Intersection) ?