VPS35 and SNX1

Number of citations of the paper that reports this interaction (PMID 11102511)
68

Data Source:
HPRD (in vivo)

		VPS35	SNX1
Gene Name		vacuolar protein sorting 35 homolog (S. cerevisiae)	sorting nexin 1
Image
Gene Ontology Annotations	Cellular Component	Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Retromer Complex Extracellular Vesicular Exosome Tubular Endosome	Cytoplasm Golgi Apparatus Cytosol Endosome Membrane Membrane Extrinsic Component Of Membrane Lamellipodium Retromer Complex Early Endosome Membrane Intracellular Membrane-bounded Organelle Protein Complex
	Molecular Function	Protein Binding Protein Transporter Activity	Epidermal Growth Factor Receptor Binding Insulin Receptor Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Transferrin Receptor Binding Leptin Receptor Binding
	Biological Process	Intracellular Protein Transport Retrograde Transport, Endosome To Golgi Transcytosis Negative Regulation Of Late Endosome To Lysosome Transport Retrograde Transport, Endosome To Plasma Membrane	Intracellular Protein Transport Vesicle Organization Receptor Internalization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Positive Regulation Of Protein Catabolic Process Lamellipodium Morphogenesis
Pathways		WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Signaling by Wnt Signaling by WNT in cancer WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: APP FAM21C MTNR1B SNX1 SNX3 VEGFA VPS26B VPS29 ZNF512B	25 interactors: ACVR1B ACVR2B AGTRAP APP ARFIP2 ARL6IP1 ATXN7 CMTM5 EGFR F2R FUNDC1 HGS INSR LEPR PDGFRB RABAC1 REEP6 RTN3 RTN4 SNX2 SNX32 SNX6 TK1 UFD1L VPS35
Entrez ID		55737	6642
HPRD ID		06085	03171
Ensembl ID			ENSG00000028528
Uniprot IDs		Q96QK1	Q13596
PDB IDs		2R17	2I4K 4FZS
Enriched GO Terms of Interacting Partners?		Retrograde Transport, Endosome To Golgi Vesicle-mediated Transport Endosomal Transport Establishment Of Localization In Cell Cellular Localization Intracellular Transport Retrograde Transport, Endosome To Plasma Membrane Regulation Of Cell Development Platelet Degranulation Positive Regulation Of Protein Kinase D Signaling Basophil Chemotaxis Intralumenal Vesicle Formation Transport Positive Regulation Of Protein Localization To Early Endosome Synaptic Growth At Neuromuscular Junction Negative Regulation Of Barbed-end Actin Filament Capping Negative Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Retinal Ganglion Cell Axon Guidance Coronary Vein Morphogenesis Primitive Erythrocyte Differentiation VEGF-activated Neuropilin Signaling Pathway Regulation Of Receptor Activity Regulation Of Neuron Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Regulation Of Barbed-end Actin Filament Capping Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Histone Deacetylase Activity Protein Transport Cell Maturation Establishment Of Protein Localization Positive Regulation Of Lymphangiogenesis Cardiac Vascular Smooth Muscle Cell Development Positive Regulation Of Mast Cell Chemotaxis Regulation Of Retinal Ganglion Cell Axon Guidance Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cell Differentiation Lamellipodium Morphogenesis Collateral Sprouting Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway Axon Midline Choice Point Recognition Regulation Of Histone Deacetylase Activity Regulation Of Neurogenesis Regulation Of Endocytosis Positive Regulation Of Deacetylase Activity Coronary Artery Morphogenesis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Platelet Activation Regulation Of Cell-substrate Adhesion	Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Establishment Of Protein Localization Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Digestive System Development Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cell Migration Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Activin Receptor Signaling Pathway Endoplasmic Reticulum Tubular Network Organization Regulation Of Signal Transduction Regulation Of Cell Motility Retrograde Transport, Endosome To Golgi Protein Transport Regulation Of Locomotion Regulation Of Cellular Component Movement Endosomal Transport Regulation Of Peptidyl-tyrosine Phosphorylation Vesicle Organization Protein Localization Protein Autophosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Kinase Activity Regulation Of JAK-STAT Cascade Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Metabolic Process Activation Of Protein Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Phosphorylation Signal Transduction By Phosphorylation Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Cycle Positive Regulation Of Transferase Activity Positive Regulation Of Protein Modification Process Intracellular Protein Transport Positive Regulation Of Mitotic Cell Cycle
Tagcloud ?		allosteric biophysical cargo consists deciphered disrupts endosomal endosomes fret golgi gtpase hela insights instrumental nexins perturbed rab7 recognizing recruit recruitment recruits recycle retromer snx sorting sub vacuolar vps26	apical auxin brassinosteroid bundle carrier clasp cytokinin cytoskeleton division edges efflux elongation endosomes fine maxima meristem microtubule microtubules modulates normally optimize pin2 prevailing sharp tethering transfacial transitions tunes works
Tagcloud (Difference) ?		allosteric biophysical cargo consists deciphered disrupts endosomal fret golgi gtpase hela insights instrumental nexins perturbed rab7 recognizing recruit recruitment recruits recycle retromer snx sorting sub vacuolar vps26	apical auxin brassinosteroid bundle carrier clasp cytokinin cytoskeleton division edges efflux elongation fine maxima meristem microtubule microtubules modulates normally optimize pin2 prevailing sharp tethering transfacial transitions tunes works
Tagcloud (Intersection) ?		endosomes