VPS35 and VPS29

Number of citations of the paper that reports this interaction (PubMedID 40437099)
172

Data Source:
BioGRID (affinity chromatography technology, biochemical)
HPRD (in vitro, two hybrid)

		VPS35	VPS29
Description		VPS35 retromer complex component	VPS29 retromer complex component
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Lysosome Lysosomal Membrane Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Postsynaptic Density Membrane Retromer Complex Retromer, Cargo-selective Complex Neuron Projection Neuronal Cell Body Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Tubular Endosome Dopaminergic Synapse Presynapse Postsynapse Glutamatergic Synapse Mitochondrion-derived Vesicle	Cytoplasm Endosome Early Endosome Late Endosome Cytosol Endosome Membrane Membrane Retromer Complex Retromer, Cargo-selective Complex
	Molecular Function	Protein Binding D1 Dopamine Receptor Binding	Protein Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Lysosome Organization Positive Regulation Of Signal Transduction Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Regulation Of Mitochondrion Organization Protein Transport Wnt Signaling Pathway Regulation Of Macroautophagy Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Negative Regulation Of Protein Homooligomerization Protein Localization To Organelle Protein Localization To Endosome Retrograde Transport, Endosome To Golgi Regulation Of Protein Catabolic Process Mitochondrial Fragmentation Involved In Apoptotic Process Transcytosis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Inflammatory Response Regulation Of Developmental Process Modulation Of Chemical Synaptic Transmission Voluntary Musculoskeletal Movement Regulation Of Transport Regulation Of Protein Metabolic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Positive Regulation Of Wnt Protein Secretion Regulation Of Synapse Maturation Positive Regulation Of Mitochondrial Fission Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Locomotion Involved In Locomotory Behavior Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Mitochondrion To Lysosome Vesicle-mediated Transport Regulation Of Postsynapse Organization Neurotransmitter Receptor Transport, Endosome To Plasma Membrane Regulation Of Postsynapse Assembly Negative Regulation Of Late Endosome To Lysosome Transport Regulation Of Dendritic Spine Maintenance Positive Regulation Of Dopamine Biosynthetic Process Negative Regulation Of Protein Localization Positive Regulation Of Protein Localization Positive Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Lysosomal Protein Catabolic Process Regulation Of Presynapse Assembly Regulation Of Terminal Button Organization	Intracellular Protein Transport Regulation Of Autophagy Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Golgi
Pathways		WNT ligand biogenesis and trafficking	WNT ligand biogenesis and trafficking
Drugs
Diseases
GWAS
Interacting Genes		15 interacting genes: APP DRD1 FILNC1 GNL1 LINC01554 MTNR1B PRPF19 SLC11A2 SNX1 USP7 VEGFA VPS26B VPS29 YBX1 ZNF512B	6 interacting genes: APP FRA10AC1 RGS2 SNCA TMCO4 VPS35
Entrez ID		55737	51699
HPRD ID		06085	09499
Ensembl ID		ENSG00000069329	ENSG00000111237
Uniprot IDs		Q96QK1	A0A384MR19 F8VXU5 Q9UBQ0
PDB IDs		2R17 5F0J 5F0K 5F0L 5F0M 5F0P 5OSH 5OSI 7BLN 7BLO 8R02 8R0J 8RKS	1W24 2R17 5GTU 5OSH 5OSI 5WYH 6XS5 6XS7 6XS9 6XSA 7BLN 8ESE 8P0V 8P0X 8R02 8R0J 8RKS 8SYM 8SYN 8SYO 9AU7
Enriched GO Terms of Interacting Partners?		Negative Regulation Of MiRNA Transcription Retromer Complex Retromer, Cargo-selective Complex Early Endosome Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Retrograde Transport, Endosome To Golgi Mating Behavior Cellular Response To Catecholamine Stimulus Regulation Of Neurotransmitter Uptake Response To Catecholamine Insulin Receptor Binding Cytosolic Transport Positive Regulation Of Receptor Internalization Blood Vessel Diameter Maintenance Regulation Of Tube Size Late Endosome Endosome Chemoattractant Activity Reproductive Behavior Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Early Endosome Membrane Amylin Binding Positive Regulation Of Toll Signaling Pathway Positive Chemotaxis Regulation Of Protein Localization Nickel Cation Transmembrane Transporter Activity Nickel Cation Transmembrane Transport Vanadium Ion Transport Paraferritin Complex Lead Ion Transport Chromium Ion Transmembrane Transporter Activity Lead Ion Transmembrane Transporter Activity Vanadium Ion Transmembrane Transporter Activity VEGF-A Complex Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway Basophil Chemotaxis Visual Learning Positive Regulation Of Receptor-mediated Endocytosis Vasodilation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Intracellular Protein Transport Acetylcholine Receptor Activator Activity Cell Projection Morphogenesis Myeloid Cell Development Visual Behavior Learning Or Memory Platelet Alpha Granule Lumen	Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Dendritic Spine Maintenance Regulation Of Synapse Assembly Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Cellular Response To Copper Ion Regulation Of Long-term Neuronal Synaptic Plasticity Amyloid Fibril Formation Microglial Cell Activation Presynapse Response To Copper Ion Postsynapse Leukocyte Activation Involved In Inflammatory Response Regulation Of Cell Junction Assembly Beta-tubulin Binding Regulation Of Synapse Organization Regulation Of Neuronal Synaptic Plasticity Protein Destabilization Amyloid-beta Complex Growth Cone Lamellipodium Myeloid Cell Development Regulation Of Response To Calcium Ion Macrophage Activation Amylin Binding Positive Regulation Of Toll Signaling Pathway Regulation Of Protein Catabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Regulation Of Terminal Button Organization Regulation Of Amine Transport Positive Regulation Of Protein Localization To Cell Periphery Adult Locomotory Behavior Regulation Of Inflammatory Response Response To Interleukin-1 Negative Regulation Of Transport Positive Regulation Of Cellular Component Organization Positive Regulation Of Protein Localization Protein Tetramerization Vesicle-mediated Transport In Synapse Acetylcholine Receptor Activator Activity Modulation Of Chemical Synaptic Transmission
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?