RIGI and PRKCG

Number of citations of the paper that reports this interaction (PubMedID 22114345)
33

Data Source:
BioGRID (enzymatic study)

		RIGI	PRKCG
Description		RNA sensor RIG-I	protein kinase C gamma
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Anchoring Junction Ribonucleoprotein Complex	Nucleus Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Postsynaptic Density Membrane Dendrite Cell Projection Neuron Projection Calyx Of Held Synapse Perinuclear Region Of Cytoplasm Synaptic Membrane Presynaptic Cytosol Postsynaptic Cytosol
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Double-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Pattern Recognition Receptor Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Transcription Detection Of Virus Response To Virus Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Chemosensory Behavior Response To Toxic Substance Negative Regulation Of Protein Ubiquitination Regulation Of Response To Food Positive Regulation Of Mismatch Repair Intracellular Signal Transduction Negative Regulation Of Protein Catabolic Process Regulation Of Circadian Rhythm Response To Morphine Negative Regulation Of Neuron Apoptotic Process Response To Pain Rhythmic Process Regulation Of Phagocytosis Long-term Synaptic Potentiation Innervation Presynaptic Modulation Of Chemical Synaptic Transmission Synaptic Signaling Via Neuropeptide Negative Regulation Of Proteasomal Protein Catabolic Process Response To Angiotensin Response To Psychosocial Stress Regulation Of Synaptic Vesicle Exocytosis
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions Modulation of host responses by IFN-stimulated genes	Calmodulin induced events Disinhibition of SNARE formation Trafficking of GluR2-containing AMPA receptors G alpha (z) signalling events WNT5A-dependent internalization of FZD4 Response to elevated platelet cytosolic Ca2+
Drugs			Tamoxifen Staurosporine Dequalinium Benzoyl peroxide Fostamatinib
Diseases			Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Interacting Genes		21 interacting genes: CCDC50 CYLD DHX16 FILNC1 IRGM MAVS PRKCG RNF122 RNF125 RNF135 SNX5 THAP12 TRIM40 TRIM6 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 USP15 USP3	64 interacting genes: AFAP1 ANXA7 APP ARHGEF25 ARHGEF7 CASR CCHCR1 CD5 CDC42 CHAT CTNNB1 CYTH2 DAB2 DNAJC5 DVL2 EIF4E EPHB1 EXOC5 FBXO7 GABRA1 GABRA4 GFAP GJA1 GJA3 GRIA4 GRIN1 GRIN2B GRIN2D GRK2 GRM5 GSK3A HABP4 HSPA4 IRS1 ITGB2 MAPT MARK4 NOXA1 NRGN NUMB PA2G4 PARD3 PARD6A PARD6B PDLIM5 PEBP1 PICK1 PNMA1 PPP1R14A RANBP10 RGS2 RIGI SCN3A SDC2 SMURF1 STXBP1 TIAM1 TOP2A TRIM5 UBE2T VTN YWHAB YWHAE YWHAG
Entrez ID		23586	5582
HPRD ID		13131	01502
Ensembl ID		ENSG00000107201	ENSG00000126583
Uniprot IDs		A0AAQ5BIG4 O95786	A0A804HIU5 B2R5T1 B7Z3W6 P05129
PDB IDs		2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV 7BAH 7BAI 7JL1 7JL3 7MK1 7TNX 7TNY 7TNZ 7TO0 7TO1 7TO2 8DVR 8DVS 8DVU 8G7T 8G7U 8G7V 8SCZ 8SD0	2E73 2UZP
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Type I Interferon Production Protein Ubiquitination Protein Polyubiquitination Antiviral Innate Immune Response Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response NLRP3 Inflammasome Complex Assembly Defense Response To Symbiont Defense Response To Other Organism Macromolecule Metabolic Process Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Proteolysis Ubiquitin Conjugating Enzyme Activity Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Negative Regulation Of Type I Interferon Production Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Free Ubiquitin Chain Polymerization Macromolecule Catabolic Process Type I Interferon-mediated Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Regulation Of Cytokine Production Positive Regulation Of Peptidyl-threonine Phosphorylation Modification-dependent Protein Catabolic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Zinc Ion Binding Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Interferon-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Immune Response CARD Domain Binding	Cytoplasm Regulation Of Synaptic Plasticity Regulation Of Membrane Potential Postsynapse Regulation Of Cell Communication Regulation Of Signaling Plasma Membrane Cytosol Regulation Of Cell Projection Organization Modulation Of Chemical Synaptic Transmission Regulation Of Postsynaptic Membrane Potential Cell-cell Signaling Regulation Of Transport Signaling Cell Junction Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Cell Communication Chemical Synaptic Transmission Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Synaptic Signaling Ionotropic Glutamate Receptor Signaling Pathway Regulation Of Protein Localization Postsynaptic Membrane Regulation Of Biological Quality Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Ligand-gated Ion Channel Signaling Pathway Focal Adhesion Regulation Of Signal Transduction Neuron Projection Cell Junction Assembly PAR Polarity Complex Protein Kinase C Binding Protein Kinase Binding Regulation Of System Process Positive Regulation Of Synaptic Transmission Positive Regulation Of Cell Communication Positive Regulation Of Signaling NMDA Glutamate Receptor Activity Glutamate Binding Developmental Process Positive Regulation Of Transport Positive Regulation Of Multicellular Organismal Process Regulation Of Neuronal Synaptic Plasticity Anchoring Junction Monoatomic Ion Channel Activity Positive Regulation Of Cellular Component Organization Regulation Of Presynaptic Membrane Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity
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