RIGI and IRGM

Number of citations of the paper that reports this interaction (PubMedID 32715615)
109

Data Source:
BioGRID (pull down)

		RIGI	IRGM
Description		RNA sensor RIG-I	immunity related GTPase M
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Anchoring Junction Ribonucleoprotein Complex	Golgi Membrane Autophagosome Membrane Phagocytic Cup Mitochondrion Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Phagocytic Vesicle Membrane Cytoplasmic Vesicle Late Endosome Membrane Mitochondrial Membrane Cell Projection
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Double-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Pattern Recognition Receptor Activity Identical Protein Binding Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Protein Kinase Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity CARD Domain Binding BH3 Domain Binding Cardiolipin Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Transcription Detection Of Virus Response To Virus Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response	Autophagosome Assembly Positive Regulation Of Protein Phosphorylation Immune System Process Autophagy Inflammatory Response Lysosome Organization Positive Regulation Of Autophagy Positive Regulation Of Peptidyl-threonine Phosphorylation Protein Catabolic Process Protein Destabilization Negative Regulation Of Type I Interferon Production Negative Regulation Of Type II Interferon Production Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Interferon-beta Defense Response To Bacterium Positive Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Protein-containing Complex Assembly NLRP3 Inflammasome Complex Assembly Innate Immune Response Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Protein Stabilization Defense Response To Gram-negative Bacterium Positive Regulation Of Type II Interferon-mediated Signaling Pathway Regulation Of Protein Complex Stability Protein Lipidation Involved In Autophagosome Assembly CAMKK-AMPK Signaling Cascade Protein-containing Complex Assembly Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein Targeting To Vacuole Involved In Autophagy Cellular Response To Lipopolysaccharide Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Mitochondrial Fission Autophagosome Maturation Cellular Response To Virus Antibacterial Innate Immune Response Negative Regulation Of CGAS/STING Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Autophagosome Maturation Positive Regulation Of Mitophagy Positive Regulation Of Xenophagy Positive Regulation Of Lysosome Organization
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS			Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 17554261 17554300 18587394 21102463 28067908) Dimensional psychopathology (Arousal) ( 29496196) Inflammatory bowel disease ( 23128233 28067908)
Interacting Genes		21 interacting genes: CCDC50 CYLD DHX16 FILNC1 IRGM MAVS PRKCG RNF122 RNF125 RNF135 SNX5 THAP12 TRIM40 TRIM6 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 USP15 USP3	10 interacting genes: ATG10 ATG5 CGAS MAP1LC3C NLRP3 NOD1 NOD2 RIGI SH3GLB1 TLR3
Entrez ID		23586	345611
HPRD ID		13131	19559
Ensembl ID		ENSG00000107201	ENSG00000237693
Uniprot IDs		A0AAQ5BIG4 O95786	A1A4Y4
PDB IDs		2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV 7BAH 7BAI 7JL1 7JL3 7MK1 7TNX 7TNY 7TNZ 7TO0 7TO1 7TO2 8DVR 8DVS 8DVU 8G7T 8G7U 8G7V 8SCZ 8SD0
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Type I Interferon Production Protein Ubiquitination Protein Polyubiquitination Antiviral Innate Immune Response Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response NLRP3 Inflammasome Complex Assembly Defense Response To Symbiont Defense Response To Other Organism Macromolecule Metabolic Process Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Proteolysis Ubiquitin Conjugating Enzyme Activity Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Negative Regulation Of Type I Interferon Production Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Free Ubiquitin Chain Polymerization Macromolecule Catabolic Process Type I Interferon-mediated Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Regulation Of Cytokine Production Positive Regulation Of Peptidyl-threonine Phosphorylation Modification-dependent Protein Catabolic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Zinc Ion Binding Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Interferon-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Immune Response CARD Domain Binding	Regulation Of Production Of Molecular Mediator Of Immune Response Regulation Of Cytokine Production Involved In Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Activation Of Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Cytokine Production Involved In Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Pattern Recognition Receptor Activity Autophagy Positive Regulation Of Innate Immune Response Innate Immune Response Immune Response-activating Signaling Pathway Defense Response To Symbiont Positive Regulation Of Interleukin-8 Production Immune Response-regulating Signaling Pathway Defense Response To Other Organism Response To Stress Activation Of Immune Response Regulation Of Cytokine Production Regulation Of Defense Response Positive Regulation Of Defense Response Cellular Response To Exogenous DsRNA Regulation Of Dendritic Cell Cytokine Production Intracellular Receptor Signaling Pathway Peptidoglycan Binding Positive Regulation Of Cytokine Production Regulation Of Interleukin-8 Production Regulation Of Immune Response Cellular Response To DsRNA Positive Regulation Of Interleukin-6 Production Positive Regulation Of Immune Effector Process Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Response To Other Organism Positive Regulation Of Immune Response Detection Of Biotic Stimulus Regulation Of Type I Interferon Production Immune Response Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Interleukin-6 Production Response To Exogenous DsRNA Response To Virus Response To External Biotic Stimulus Macroautophagy Defense Response Detection Of Virus Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy
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