DDX58 and RNF135

Number of citations of the paper that reports this interaction (PMID 19484123)
23

Data Source:
BioGRID (enzymatic study)

		DDX58	RNF135
Gene Name		DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	ring finger protein 135
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Tight Junction Actin Cytoskeleton Ruffle Membrane	Cytoplasm Cytosol
	Molecular Function	Double-stranded DNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity Ribonucleoprotein Complex Binding
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Metabolic Process Detection Of Virus Response To Virus Viral Process Regulation Of Cell Migration Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus RIG-I Signaling Pathway Positive Regulation Of Transcription Factor Import Into Nucleus Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity	Protein Ubiquitination Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Innate Immune Response Regulation Of Innate Immune Response
Pathways		TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling ISG15 antiviral mechanism Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Antiviral mechanism by IFN-stimulated genes Innate Immune System	TRAF3-dependent IRF activation pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Innate Immune System
Drugs
Diseases
GWAS			Height ( 18391951)
Protein-Protein Interactions		13 interactors: CYLD MAVS PRKCG PRKRIR RNF135 TRIM25 UBC UBE2D1 UBE2D2 UBE2D3 UBE2K USP3 WRNIP1	5 interactors: CTNNAL1 DDX58 GOLGA2 RARRES3 UBE2D2
Entrez ID		23586	84282
HPRD ID		13131	11506
Ensembl ID		ENSG00000107201	ENSG00000181481
Uniprot IDs		B3KWW1 F5H5W6 O95786	B3KV69 Q8IUD6
PDB IDs		2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3TMI 3ZD6 3ZD7 4AY2 4BPB
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type I Interferon Production Regulation Of Type I Interferon Production Response To Stress Regulation Of Innate Immune Response Innate Immune Response Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Cytokine Production Immune Response Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Defense Response Protein K48-linked Ubiquitination Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of DNA-templated Transcription In Response To Stress Protein Polyubiquitination TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Immune Response-regulating Signaling Pathway Toll-like Receptor 4 Signaling Pathway Cellular Macromolecule Catabolic Process Regulation Of Immune Response Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of Cytokine Production Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Immune System Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Cellular Protein Modification Process Positive Regulation Of Immune Response Response To Stimulus Regulation Of Protein Catabolic Process Regulation Of Immune System Process Cellular Response To Stimulus Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Immune System Process Cellular Response To Stress Proteolysis Regulation Of I-kappaB Kinase/NF-kappaB Signaling	Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response RIG-I Signaling Pathway Regulation Of Type III Interferon Production Detection Of Virus Regulation Of Innate Immune Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus Cellular Response To Virus Positive Regulation Of Defense Response To Virus By Host Immune Response-regulating Signaling Pathway Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Regulation Of Defense Response To Virus By Host Positive Regulation Of Immune Response
Tagcloud ?		adenovirus apobec3a exact expand hiv ifi27 ifi44l ifit1 ifit2 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr	asians blacks brd3 challenges childhood crlf2 cured differ differentially disparities distributed erbb2 erbb3 ethnic exist follows hispanics implicated lymphoblastic networks pdgf pediatric persist phf6 pi3 populations racial united whites
Tagcloud (Difference) ?		adenovirus apobec3a exact expand hiv ifi27 ifi44l ifit1 ifit2 ifit3 innate irf7 isg15 isg20 isgs mdms microarray monocyte mx1 mx2 reservoirs rig rsad2 select stat1 tnfsf10 trail viperin vpr	asians blacks brd3 challenges childhood crlf2 cured differ differentially disparities distributed erbb2 erbb3 ethnic exist follows hispanics implicated lymphoblastic networks pdgf pediatric persist phf6 pi3 populations racial united whites
Tagcloud (Intersection) ?