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DDX58 and USP3
Number of citations of the paper that reports this interaction (PMID
24366338
)
1
Data Source:
BioGRID
(affinity chromatography technology, enzymatic study)
DDX58
USP3
Gene Name
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
ubiquitin specific peptidase 3
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Cytoplasm
Cytosol
Tight Junction
Actin Cytoskeleton
Ruffle Membrane
Nuclear Chromatin
Molecular Function
Double-stranded DNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
Helicase Activity
Protein Binding
ATP Binding
Zinc Ion Binding
Identical Protein Binding
Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Cysteine-type Endopeptidase Activity
Ubiquitin-specific Protease Activity
Zinc Ion Binding
Histone Binding
Biological Process
Positive Regulation Of Defense Response To Virus By Host
Metabolic Process
Detection Of Virus
Response To Virus
Viral Process
Regulation Of Cell Migration
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Regulation Of Type III Interferon Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus
RIG-I Signaling Pathway
Positive Regulation Of Transcription Factor Import Into Nucleus
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Mitotic Cell Cycle
DNA Repair
Regulation Of Transcription, DNA-templated
Histone Deubiquitination
Regulation Of Protein Stability
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Pathways
TRAF3-dependent IRF activation pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
Negative regulators of RIG-I/MDA5 signaling
ISG15 antiviral mechanism
Interferon Signaling
TRAF6 mediated IRF7 activation
Cytokine Signaling in Immune system
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Antiviral mechanism by IFN-stimulated genes
Innate Immune System
Drugs
Diseases
GWAS
Heart failure (
20445134
)
Protein-Protein Interactions
13 interactors:
CYLD
MAVS
PRKCG
PRKRIR
RNF135
TRIM25
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2K
USP3
WRNIP1
3 interactors:
DDX58
IFIH1
UBC
Entrez ID
23586
9960
HPRD ID
13131
05290
Ensembl ID
ENSG00000107201
Uniprot IDs
B3KWW1
F5H5W6
O95786
Q9Y6I4
PDB IDs
2LWD
2LWE
2QFB
2QFD
2RMJ
2YKG
3LRN
3LRR
3NCU
3OG8
3TMI
3ZD6
3ZD7
4AY2
4BPB
Enriched GO Terms of Interacting Partners
?
Negative Regulation Of Type I Interferon Production
Regulation Of Type I Interferon Production
Response To Stress
Regulation Of Innate Immune Response
Innate Immune Response
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Negative Regulation Of Cytokine Production
Immune Response
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Defense Response
Protein K48-linked Ubiquitination
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Ubiquitination
Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Regulation Of DNA-templated Transcription In Response To Stress
Protein Polyubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Toll-like Receptor 3 Signaling Pathway
Immune Response-regulating Signaling Pathway
Toll-like Receptor 4 Signaling Pathway
Cellular Macromolecule Catabolic Process
Regulation Of Immune Response
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Regulation Of Cytokine Production
Cellular Response To Hypoxia
Cellular Response To Decreased Oxygen Levels
Immune System Process
Toll-like Receptor Signaling Pathway
Cellular Response To Oxygen Levels
Cellular Protein Modification Process
Positive Regulation Of Immune Response
Response To Stimulus
Regulation Of Protein Catabolic Process
Regulation Of Immune System Process
Cellular Response To Stimulus
Regulation Of Proteasomal Protein Catabolic Process
Positive Regulation Of Immune System Process
Cellular Response To Stress
Proteolysis
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Type I Interferon Production
Regulation Of Type III Interferon Production
Detection Of Virus
Positive Regulation Of Type I Interferon Production
Regulation Of Type I Interferon Production
Cytoplasmic Pattern Recognition Receptor Signaling Pathway In Response To Virus
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response-activating Signal Transduction
Activation Of Innate Immune Response
Positive Regulation Of Innate Immune Response
Intracellular Receptor Signaling Pathway
Negative Regulation Of Cytokine Production
Regulation Of Innate Immune Response
Cellular Response To Virus
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Cytokine Production
Immune Response-regulating Signaling Pathway
Regulation Of Interferon-beta Production
Regulation Of Cytokine Production
Viral Process
Positive Regulation Of Immune Response
Innate Immune Response
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Defense Response To Virus
Immune Response
Regulation Of Immune System Process
Defense Response
Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
RIG-I Signaling Pathway
Response To Virus
Intracellular Signal Transduction
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Immune System Process
Viral Protein Processing
Protein Modification By Small Protein Conjugation
Positive Regulation Of Defense Response To Virus By Host
Response To Other Organism
Notch Receptor Processing
Virion Assembly
Response To Biotic Stimulus
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Response To Stress
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein Sumoylation
Glycogen Biosynthetic Process
Intracellular Transport Of Virus
Regulation Of Defense Response To Virus By Host
Positive Regulation Of Transcription Factor Import Into Nucleus
Tagcloud
?
adenovirus
apobec3a
exact
expand
hiv
ifi27
ifi44l
ifit1
ifit2
ifit3
innate
irf7
isg15
isg20
isgs
mdms
microarray
monocyte
mx1
mx2
reservoirs
rig
rsad2
select
stat1
tnfsf10
trail
viperin
vpr
Tagcloud (Difference)
?
adenovirus
apobec3a
exact
expand
hiv
ifi27
ifi44l
ifit1
ifit2
ifit3
innate
irf7
isg15
isg20
isgs
mdms
microarray
monocyte
mx1
mx2
reservoirs
rig
rsad2
select
stat1
tnfsf10
trail
viperin
vpr
Tagcloud (Intersection)
?