RIGI and USP3

Number of citations of the paper that reports this interaction (PubMedID 24366338)
39

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		RIGI	USP3
Description		RNA sensor RIG-I	ubiquitin specific peptidase 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Bicellular Tight Junction Actin Cytoskeleton Membrane Ruffle Membrane Cell Projection Anchoring Junction Ribonucleoprotein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytoplasmic Ribonucleoprotein Granule Flemming Body
	Molecular Function	Nucleotide Binding Nucleic Acid Binding Double-stranded DNA Binding RNA Binding RNA Helicase Activity Double-stranded RNA Binding Single-stranded RNA Binding Helicase Activity Protein Binding ATP Binding GTP Binding Zinc Ion Binding Hydrolase Activity ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Pattern Recognition Receptor Activity Identical Protein Binding Metal Ion Binding	Cysteine-type Deubiquitinase Activity Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Histone Binding Metal Ion Binding Histone H2B Deubiquitinase Activity Histone H2A Deubiquitinase Activity
	Biological Process	Positive Regulation Of Defense Response To Virus By Host Immune System Process Positive Regulation Of Immune System Process Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MRNA Transcription Detection Of Virus Response To Virus Gene Expression Positive Regulation Of Gene Expression Regulation Of Cell Migration Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type III Interferon Production RIG-I Signaling Pathway Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Antiviral Innate Immune Response	DNA Repair Chromatin Organization Proteolysis DNA Damage Response Protein Deubiquitination DNA Repair-dependent Chromatin Remodeling
Pathways		ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Ub-specific processing proteases Ovarian tumor domain proteases OAS antiviral response TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses SARS-CoV-2 activates/modulates innate and adaptive immune responses Evasion by RSV of host interferon responses RSV-host interactions Modulation of host responses by IFN-stimulated genes	Ub-specific processing proteases
Drugs
Diseases
GWAS			A body shape index ( 34021172) Aortic root size ( 28394258) Atrial fibrillation ( 29892015) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Daytime nap ( 33568662) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil percentage of white cells ( 32888494) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Heart failure ( 20445134) Heel bone mineral density ( 28869591 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) LDL cholesterol levels ( 32203549) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum immune biomarker levels ( 32066700) Triglyceride levels ( 32203549) Type 2 diabetes ( 30054458 30297969) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		21 interacting genes: CCDC50 CYLD DHX16 FILNC1 IRGM MAVS PRKCG RNF122 RNF125 RNF135 SNX5 THAP12 TRIM40 TRIM6 TRIM65 UBC UBE2D1 UBE2D2 UBE2D3 USP15 USP3	6 interacting genes: CHEK1 IFIH1 PYCARD RIGI TP53 UBC
Entrez ID		23586	9960
HPRD ID		13131	05290
Ensembl ID		ENSG00000107201	ENSG00000140455
Uniprot IDs		A0AAQ5BIG4 O95786	Q6JHV3 Q9Y6I4
PDB IDs		2LWD 2LWE 2QFB 2QFD 2RMJ 2YKG 3LRN 3LRR 3NCU 3OG8 3ZD6 3ZD7 4AY2 4BPB 4NQK 4ON9 4P4H 5E3H 5F98 5F9F 5F9H 6GPG 6KYV 7BAH 7BAI 7JL1 7JL3 7MK1 7TNX 7TNY 7TNZ 7TO0 7TO1 7TO2 8DVR 8DVS 8DVU 8G7T 8G7U 8G7V 8SCZ 8SD0
Enriched GO Terms of Interacting Partners?		Post-translational Protein Modification Ubiquitin Protein Ligase Activity Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Type I Interferon Production Protein Ubiquitination Protein Polyubiquitination Antiviral Innate Immune Response Protein K48-linked Ubiquitination Protein Metabolic Process Ubiquitin-protein Transferase Activity Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Innate Immune Response NLRP3 Inflammasome Complex Assembly Defense Response To Symbiont Defense Response To Other Organism Macromolecule Metabolic Process Regulation Of Defense Response Cytoplasmic Pattern Recognition Receptor Signaling Pathway Response To Virus Proteolysis Ubiquitin Conjugating Enzyme Activity Immune Response Canonical Inflammasome Complex Assembly Positive Regulation Of Interferon-beta Production Positive Regulation Of Defense Response Negative Regulation Of Type I Interferon Production Defense Response To Virus Regulation Of NLRP3 Inflammasome Complex Assembly Free Ubiquitin Chain Polymerization Macromolecule Catabolic Process Type I Interferon-mediated Signaling Pathway Response To Other Organism Pattern Recognition Receptor Signaling Pathway Regulation Of Interferon-beta Production Regulation Of Cytokine Production Positive Regulation Of Peptidyl-threonine Phosphorylation Modification-dependent Protein Catabolic Process Positive Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response-activating Signaling Pathway Zinc Ion Binding Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Defense Response To Virus Positive Regulation Of Response To Cytokine Stimulus Protein Autoubiquitination Interferon-mediated Signaling Pathway Activation Of Innate Immune Response Regulation Of Immune Response CARD Domain Binding	MRNA Transcription Pattern Recognition Receptor Activity Detection Of Virus Regulation Of Interferon-beta Production Regulation Of Type III Interferon Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Type I Interferon Production Replicative Senescence Cellular Response To Exogenous DsRNA Regulation Of Interleukin-6 Production Innate Immune Response-activating Signaling Pathway Cellular Response To DsRNA Pattern Recognition Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Release Of Cytochrome C From Mitochondria Positive Regulation Of Interferon-alpha Production Activation Of Innate Immune Response Replication Fork Positive Regulation Of Defense Response To Virus By Host Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Intracellular Signal Transduction Protein Complex Oligomerization Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Response To Exogenous DsRNA Positive Regulation Of Interferon-beta Production Defense Response To Virus Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Defense Response To Virus By Host Ubiquitin Protein Ligase Binding Positive Regulation Of Innate Immune Response Response To DsRNA Single-stranded RNA Binding Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Immune Response-activating Signaling Pathway Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-8 Production Regulation Of Defense Response To Virus Response To Virus Mitotic DNA Damage Checkpoint Signaling Mitotic DNA Integrity Checkpoint Signaling Cytokine-mediated Signaling Pathway Interferon-mediated Signaling Pathway Response To Osmotic Stress Double-stranded RNA Binding RNA Helicase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Activation Of Immune Response
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