FBH1 and DSCR9

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		FBH1	DSCR9
Description		F-box DNA helicase 1	Down syndrome critical region 9
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome SCF Ubiquitin Ligase Complex	Cellular_component
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Double-stranded DNA Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding DNA Translocase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	Molecular_function
	Biological Process	Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Protein Phosphorylation DNA Repair DNA Catabolic Process DNA Damage Response Protein Ubiquitination Replication Fork Processing Response To Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Biological_process
Pathways
Drugs
Diseases
GWAS			Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		12 interacting genes: CUL1 DSCR9 ESR1 PCNA PIM2 RAD51 RBX1 RNF20 RPL13A SKP1 UBC ZDHHC17	146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2
Entrez ID		84893	257203
HPRD ID		06243	10925
Ensembl ID		ENSG00000134452	ENSG00000230366
Uniprot IDs		B3KV95 F6UZG9 Q2TAK1 Q8NFZ0
PDB IDs		8F5Q
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Cul7-RING Ubiquitin Ligase Complex Macromolecule Metabolic Process Protein Monoubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Modification Process Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Cullin-RING Ubiquitin Ligase Complex Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation DNA Polymerase Binding Cullin Family Protein Binding Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Cell Cycle Phase Transition Protein Metabolic Process Cellular Response To Radiation Positive Regulation Of Autophagy Regulation Of Programmed Cell Death Chromatin Binding Nuclear Estrogen Receptor Binding Replication Fork Processing Cellular Response To Oxidative Stress Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Male Germ Cell Nucleus PCNA Complex Replisome Response To Glucoside Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Formation Of Translation Preinitiation Complex Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Cellular Response To Chemical Stress Proteolysis Lysosome Organization TORC1 Signaling Negative Regulation Of TORC1 Signaling Catabolic Process	Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway
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