DSCR9 and HPS4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	HPS4
Description		Down syndrome critical region 9	HPS4 biogenesis of lysosomal organelles complex 3 subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane BLOC-3 Complex Cytoplasmic Vesicle Melanosome Platelet Dense Granule
	Molecular Function	Molecular_function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding Protein Homodimerization Activity Protein Dimerization Activity
	Biological Process	Biological_process	Protein Targeting Lysosome Organization Blood Coagulation Hemostasis Vesicle-mediated Transport Melanocyte Differentiation Positive Regulation Of Eye Pigmentation Protein Stabilization Platelet Dense Granule Organization Melanosome Assembly Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Hermansky-Pudlak syndrome (HPS)
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Ischemic stroke ( 26089329)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	3 interacting genes: DSCR9 HPS1 RAC1
Entrez ID		257203	89781
HPRD ID		10925	05983
Ensembl ID		ENSG00000230366	ENSG00000100099
Uniprot IDs			A0A8V8TMY3 A0A8V8TN06 A0A8V8TPB3 A8K2E6 F1LLU8 Q6P1K3 Q9NQG7
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	BLOC-3 Complex Positive Regulation Of Ovarian Follicle Development Negative Regulation Of Interleukin-23 Production Regulation Of ERK5 Cascade Angiotensin-activated Signaling Pathway Involved In Heart Process Embryonic Olfactory Bulb Interneuron Precursor Migration Cerebral Cortex GABAergic Interneuron Development Rho GDP-dissociation Inhibitor Binding Regulation Of Cell Adhesion Involved In Heart Morphogenesis Kinocilium Regulation Of Ovarian Follicle Development G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Auditory Receptor Cell Morphogenesis Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Erythrocyte Enucleation Hepatocyte Growth Factor Receptor Signaling Pathway Engulfment Of Apoptotic Cell Tangential Migration From The Subventricular Zone To The Olfactory Bulb Positive Regulation Of Bicellular Tight Junction Assembly Regulation Of Interleukin-23 Production Regulation Of Neuron Maturation Thioesterase Binding Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Negative Regulation Of Fibroblast Migration Midbrain Dopaminergic Neuron Differentiation Ruffle Assembly Platelet Dense Granule Organization Melanosome Assembly Regulation Of Hydrogen Peroxide Metabolic Process Angiotensin-activated Signaling Pathway Rac Protein Signal Transduction Hyperosmotic Response Respiratory Burst Cochlea Morphogenesis NADPH Oxidase Complex Regulation Of Ruffle Assembly Dopaminergic Neuron Differentiation Sphingosine-1-phosphate Receptor Signaling Pathway Positive Regulation Of Neutrophil Migration Sphingolipid Mediated Signaling Pathway Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lamellipodium Assembly Cerebral Cortex Cell Migration Positive Regulation Of Ruffle Assembly Phagocytic Cup Regulation Of Cell Maturation Interneuron Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Rho Protein Signal Transduction
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