DSCR9 and SMPD3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	SMPD3
Description		Down syndrome critical region 9	sphingomyelin phosphodiesterase 3
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Golgi Cis Cisterna Golgi Membrane Extracellular Region Cytoplasm Golgi Apparatus Plasma Membrane Membrane
	Molecular Function	Molecular_function	Phosphatidylserine Binding Catalytic Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding Neutral Sphingomyelin Phosphodiesterase Activity Phosphatidic Acid Binding
	Biological Process	Biological_process	Skeletal System Development Ossification Endochondral Ossification Chondrocyte Development Hematopoietic Progenitor Cell Differentiation Regulation Of Leukocyte Migration Chondrocyte Development Involved In Endochondral Bone Morphogenesis Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Signal Transduction Polysaccharide Transport Peptide Hormone Secretion Bone Mineralization Lung Development BMP Signaling Pathway Collagen Metabolic Process Cellular Response To Reactive Oxygen Species Multicellular Organism Growth Positive Regulation Of Mitotic Nuclear Division Platelet-derived Growth Factor Receptor Signaling Pathway Lung Alveolus Development Positive Regulation Of Smooth Muscle Cell Proliferation Cartilage Development Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Bone Development Respiratory System Development Regulation Of Cartilage Development Cellular Response To Hydrogen Peroxide G1 To G0 Transition Cellular Response To Magnesium Ion Cellular Response To Tumor Necrosis Factor Cellular Response To Redox State DNA Biosynthetic Process Extracellular Matrix Assembly Sphingolipid Mediated Signaling Pathway Dentinogenesis Bone Growth Mitotic Nuclear Division Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Peptide Positive Regulation Of Exosomal Secretion
Pathways			TNFR1-mediated ceramide production Glycosphingolipid catabolism
Drugs			Phosphatidyl serine
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Birth weight ( 31043758) Chronic obstructive pulmonary disease in ever smokers ( 33106845) Chronic obstructive pulmonary disease in non-current smokers ( 33106845) Chronic obstructive pulmonary disease x current smoker interaction (2df) ( 33106845) Chronic obstructive pulmonary disease x current smoker interaction (main effect) ( 33106845) Chronic obstructive pulmonary disease x ever smoker interaction (2df) ( 33106845) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340) Hemoglobin levels ( 32327693) Lipoprotein (a) levels ( 33730874) Offspring birth weight ( 31043758) Refractive error ( 32231278)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	1 interacting genes: DSCR9
Entrez ID		257203	55512
HPRD ID		10925	16154
Ensembl ID		ENSG00000230366	ENSG00000103056
Uniprot IDs			A8K0T6 Q9NY59
PDB IDs			5UVG
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Cellular_component Molecular_function
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