DSCR9 and MTMR3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	MTMR3
Description		Down syndrome critical region 9	myotubularin related protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	Cytoplasm Cytosol Membrane
	Molecular Function	Molecular_function	Phosphatidylinositol-3-phosphate Phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Zinc Ion Binding Hydrolase Activity Protein Phosphatase Binding Metal Ion Binding Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Molecular Adaptor Activity
	Biological Process	Biological_process	Protein Dephosphorylation Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Macroautophagy Cellular Response To Glucose Starvation Phosphatidylinositol Dephosphorylation Regulation Of Phosphatidylinositol Dephosphorylation Midbody Abscission Phosphatidylinositol 5-phosphate Metabolic Process Regulation Of Autophagosome Assembly
Pathways			Macroautophagy Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Behcet's disease ( 33393726) Cerebrospinal P-tau181p levels ( 28247064) Crohn's disease ( 21102463 28067908) Delirium ( 29631748) Dentures ( 31235808) Estimated glomerular filtration rate ( 31451708 31152163) Fasting glucose ( 34059833) Hematocrit ( 32888494) Hemoglobin ( 32888494) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) IgA nephropathy ( 22197929) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) LDL cholesterol ( 24097068) LDL cholesterol levels ( 28334899) Lung cancer ( 21725308) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Nephropathy ( 21399633) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Refractive error ( 32231278) Tonsillectomy ( 28928442 27182965 27941131) Type 2 diabetes ( 30297969 29632382)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	5 interacting genes: DSCR9 EXOSC5 FGFR2 HIVEP1 LONRF1
Entrez ID		257203	8897
HPRD ID		10925	09151
Ensembl ID		ENSG00000230366	ENSG00000100330
Uniprot IDs			Q13615
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Mesenchymal Cell Differentiation Involved In Lung Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Orbitofrontal Cortex Development Fibroblast Growth Factor Receptor Signaling Pathway Involved In Negative Regulation Of Apoptotic Process In Bone Marrow Cell Fibroblast Growth Factor Receptor Signaling Pathway Involved In Mammary Gland Specification Fibroblast Growth Factor Receptor Signaling Pathway Involved In Positive Regulation Of Cell Proliferation In Bone Marrow Mammary Gland Bud Formation Fibroblast Growth Factor Receptor Signaling Pathway Involved In Hemopoiesis Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Branch Elongation Involved In Salivary Gland Morphogenesis Lung-associated Mesenchyme Development Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Prostate Epithelial Cord Arborization Involved In Prostate Glandular Acinus Morphogenesis Pyramidal Neuron Development Positive Regulation Of Lipase Activity Epithelial Cell Differentiation Involved In Prostate Gland Development Bud Elongation Involved In Lung Branching Ventricular Zone Neuroblast Division Prostate Epithelial Cord Elongation Prostate Gland Morphogenesis Mesenchymal Cell Proliferation Involved In Lung Development Endochondral Bone Growth Fibroblast Growth Factor Receptor Activity Otic Vesicle Formation Orbitofrontal Cortex Development Epithelial Cell Proliferation Involved In Salivary Gland Morphogenesis Lateral Sprouting From An Epithelium Branching Morphogenesis Of A Nerve Lung Lobe Morphogenesis Limb Bud Formation Epidermis Morphogenesis Positive Regulation Of Phospholipase Activity Forebrain Neuroblast Division Lacrimal Gland Development Forebrain Ventricular Zone Progenitor Cell Division Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Exoribonuclease Complex Poly(A)-dependent SnoRNA 3'-end Processing U4 SnRNA 3'-end Processing Branching Involved In Labyrinthine Layer Morphogenesis Membranous Septum Morphogenesis Prostate Gland Growth Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Branching Involved In Salivary Gland Morphogenesis Branching Involved In Prostate Gland Morphogenesis DNA Deamination Branch Elongation Of An Epithelium Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Mesodermal Cell Differentiation
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