DSCR9 and USP8

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	USP8
Description		Down syndrome critical region 9	ubiquitin specific peptidase 8
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Acrosomal Membrane Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Membrane Midbody Glutamatergic Synapse
	Molecular Function	Molecular_function	Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity SH3 Domain Binding Cadherin Binding K63-linked Deubiquitinase Activity K48-linked Deubiquitinase Activity
	Biological Process	Biological_process	Mitotic Cytokinesis Proteolysis Endosome Organization Ras Protein Signal Transduction Protein Deubiquitination Regulation Of Protein Stability Regulation Of Protein Localization Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Dexamethasone Stimulus Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Protein Catabolic Process At Postsynapse, Modulating Synaptic Transmission Negative Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Amyloid Fibril Formation Cellular Response To Nerve Growth Factor Stimulus
Pathways			Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Ankylosing spondylitis ( 30946743) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heel bone mineral density ( 30598549) Mean reticulocyte volume ( 32888494) Monocyte percentage of white cells ( 32888494)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	50 interacting genes: BACE1 BIRC6 BTG3 CD274 CFLAR CHMP1A CHMP1B CHMP2A CHMP2B CHMP4C CHMP7 DNAJB6 DSCR9 EPS15 GNAL GRAP2 GRB2 H2AC20 H2BC21 HUNK KIF23 MAP3K7 NBR1 NFE2L2 NTRK2 PJA1 PLA2G2A RASGRF1 RNF41 SEC31A SHANK1 SHANK3 SLBP SNCA SPP1 SQSTM1 SRC STAM STAM2 TGFBR2 TRIM54 TRIM55 TRIM63 UBC USP15 USP21 USP28 YWHAG YWHAQ YWHAZ
Entrez ID		257203	9101
HPRD ID		10925	04405
Ensembl ID		ENSG00000230366	ENSG00000138592
Uniprot IDs			A8K8N5 P40818
PDB IDs			1WHB 2A9U 2GFO 2GWF 3N3K 6F09 8ADM 8XPN 8Y9A
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Multivesicular Body Organization Multivesicular Body Assembly ESCRT III Complex Amphisome Membrane Vesicle Fusion With Vacuole Late Endosome To Vacuole Transport Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body-lysosome Fusion Membrane Fission Viral Budding From Plasma Membrane Multivesicular Body Sorting Pathway Lysosomal Membrane Organization Protein Domain Specific Binding Endosome Organization Late Endosome To Lysosome Transport Kinetochore Microtubule Viral Budding Via Host ESCRT Complex Autophagy ESCRT III Complex Disassembly Regulation Of Mitotic Spindle Assembly ESCRT Complex Disassembly Midbody Abscission Multivesicular Body Viral Budding Nuclear Membrane Reassembly Mitotic Cytokinetic Process Multivesicular Body Membrane Viral Release From Host Cell Plasma Membrane Repair Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Spindle Assembly Cytosol Vacuolar Transport Cytokinetic Process Endosome Regulation Of Mitotic Spindle Organization Proteolysis Endosomal Transport Mitotic Metaphase Chromosome Alignment Nuclear Membrane Organization Autophagosome Maturation Autophagosome Membrane Metaphase Chromosome Alignment Membrane Assembly Biological Process Involved In Interaction With Host Macroautophagy Vesicle Organization Regulation Of Microtubule Cytoskeleton Organization Proteolysis Involved In Protein Catabolic Process Midbody
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