DSCR9 and DDX3X

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	DDX3X
Description		Down syndrome critical region 9	DEAD-box helicase 3 X-linked
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Extracellular Region Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Eukaryotic Translation Initiation Factor 3 Complex Cytoskeleton Plasma Membrane Cytoplasmic Stress Granule Membrane Cytosolic Small Ribosomal Subunit Lamellipodium Cell Leading Edge Secretory Granule Lumen Cell Projection P Granule Canonical Inflammasome Complex Extracellular Exosome NLRP3 Inflammasome Complex Ficolin-1-rich Granule Lumen
	Molecular Function	Molecular_function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding GTPase Activity Helicase Activity Protein Binding ATP Binding Transcription Factor Binding Poly(A) Binding Eukaryotic Initiation Factor 4E Binding Hydrolase Activity ATP Hydrolysis Activity Ribonucleoside Triphosphate Phosphatase Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Signaling Adaptor Activity RNA Stem-loop Binding Gamma-tubulin Binding Ribosomal Small Subunit Binding CTPase Activity Protein Serine/threonine Kinase Activator Activity Cadherin Binding MRNA 5'-UTR Binding
	Biological Process	Biological_process	Immune System Process Cytoplasmic Pattern Recognition Receptor Signaling Pathway Translational Initiation Regulation Of Translation Apoptotic Process Chromosome Segregation Gamete Generation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Response To Virus Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Translation Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Stress Granule Assembly Positive Regulation Of Toll-like Receptor 7 Signaling Pathway Positive Regulation Of Toll-like Receptor 8 Signaling Pathway Intracellular Signal Transduction Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Ribosome Biogenesis Cytosolic Ribosome Assembly Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Translational Initiation Lipid Homeostasis Positive Regulation Of Mitochondrial Translation Cellular Response To Arsenic-containing Substance Cellular Response To Osmotic Stress Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Canonical Wnt Signaling Pathway Intrinsic Apoptotic Signaling Pathway Cellular Response To Virus Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of NLRP3 Inflammasome Complex Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Protein K63-linked Ubiquitination Protein Localization To Cytoplasmic Stress Granule Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways			Neutrophil degranulation
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Refractive error ( 32231278)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	105 interacting genes: ANXA1 APBB1 CEBPA CETN2 CRYAA CSNK2A1 DSCR9 DUX4 ESR1 GABRE HNF4A IKBKE IL7R LINC01232 LINC01554 MAVS MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NEDD4 NFKB2 NUP62 OGT PIN1 RABEP1 SREK1 SRPK2 SUMO2 TBC1D25 TRIM25 USP7 USP9X WBP4 XPO1 YWHAQ ZNF512B
Entrez ID		257203	1654
HPRD ID		10925	02154
Ensembl ID		ENSG00000230366	ENSG00000215301
Uniprot IDs			A0A2R8YDT5 A0A2R8YFS5 O00571
PDB IDs			2I4I 2JGN 3JRV 4O2C 4O2E 4O2F 4PX9 4PXA 5E7I 5E7J 5E7M 6CZ5 6O5F 7LIU 8SSW
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of Gene Expression Extracellular Vesicle Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Translation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Angiogenesis Negative Regulation Of Vasculature Development Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of MRNA Metabolic Process Regulation Of Angiogenesis Regulation Of Vasculature Development Regulation Of Translation Negative Regulation Of Protein Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Multicellular Organismal Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Signal Transduction Negative Regulation Of Developmental Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Endothelial Cell Migration Negative Regulation Of Signaling Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Communication Regulation Of MRNA Metabolic Process
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