FBH1 and SKP1

Number of citations of the paper that reports this interaction (PubMedID 11956208)
0

Data Source:
HPRD (in vivo)

		FBH1	SKP1
Description		F-box DNA helicase 1	S-phase kinase associated protein 1
Image
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Double-stranded DNA Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding DNA Translocase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	Protein Binding Beta-catenin Binding Protein Domain Specific Binding Cullin Family Protein Binding Molecular Function Activator Activity Ubiquitin Ligase Complex Scaffold Activity F-box Domain Binding Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Protein Phosphorylation DNA Repair DNA Catabolic Process DNA Damage Response Protein Ubiquitination Replication Fork Processing Response To Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Protein Polyubiquitination Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Location In Nucleus Axon Development Protein K48-linked Ubiquitination Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways			Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins
Drugs			1-naphthaleneacetic acid (2S)-2-(1H-indol-3-yl)hexanoic acid (2S)-2-(1H-indol-3-yl)pentanoic acid (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid Indoleacetic acid
Diseases
GWAS			Mean platelet volume ( 32888494) Systemic lupus erythematosus ( 26502338 27399966)
Interacting Genes		12 interacting genes: CUL1 DSCR9 ESR1 PCNA PIM2 RAD51 RBX1 RNF20 RPL13A SKP1 UBC ZDHHC17	77 interacting genes: ANKRD36BP1 APIP BTRC CACYBP CAND1 CCNA2 CDCA3 CDK4 CDK9 CDKN1A CDKN1B CENPE CFLAR CKS1B CTLA4 CUL1 CUL7 DDX19B FBH1 FBXL2 FBXL20 FBXL3 FBXL4 FBXL5 FBXL8 FBXO15 FBXO16 FBXO17 FBXO2 FBXO25 FBXO27 FBXO3 FBXO32 FBXO34 FBXO4 FBXO43 FBXO44 FBXO48 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GHR GLMN GPS1 HSP90AA1 KCTD9 LAMTOR5 LMO2 MED21 MEOX2 MTUS1 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPARGC1A PPP1CA PTEN RBX1 SEC23B SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C TUBA4A UBE2D1 UHRF2
Entrez ID		84893	6500
HPRD ID		06243	03255
Ensembl ID		ENSG00000134452	ENSG00000113558
Uniprot IDs		B3KV95 F6UZG9 Q2TAK1 Q8NFZ0	P63208
PDB IDs		8F5Q	1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 3WSO 4I6J 5IBK 5JH5 5K35 5V4B 5VZT 5VZU 5XYL 6BVA 6BYH 6C16 6M90 6M91 6M92 6M93 6M94 6O60 6TTU 6VCD 6W66 6WCQ 6WNX 7B5L 7B5M 7B5R 7T1Y 7T1Z 7Z8B 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4 8S7D 8S7E 8UA6 8UBT 8UBU 9CB3 9JKB 9KBD 9KBF
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Cul7-RING Ubiquitin Ligase Complex Macromolecule Metabolic Process Protein Monoubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Modification Process Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Cullin-RING Ubiquitin Ligase Complex Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation DNA Polymerase Binding Cullin Family Protein Binding Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Cell Cycle Phase Transition Protein Metabolic Process Cellular Response To Radiation Positive Regulation Of Autophagy Regulation Of Programmed Cell Death Chromatin Binding Nuclear Estrogen Receptor Binding Replication Fork Processing Cellular Response To Oxidative Stress Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Male Germ Cell Nucleus PCNA Complex Replisome Response To Glucoside Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Formation Of Translation Preinitiation Complex Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Cellular Response To Chemical Stress Proteolysis Lysosome Organization TORC1 Signaling Negative Regulation Of TORC1 Signaling Catabolic Process	SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Protein Catabolic Process Post-translational Protein Modification Macromolecule Catabolic Process Protein Metabolic Process Proteolysis Protein Modification Process Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Catabolic Process Regulation Of Cell Cycle Ubiquitin Protein Ligase Binding Cytosol Ubiquitin-protein Transferase Activity Cullin-RING Ubiquitin Ligase Complex Cytoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Glycoprotein Catabolic Process Regulation Of DNA Metabolic Process Cul7-RING Ubiquitin Ligase Complex Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Regulation Of Protein Stability Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Binding Regulation Of Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process TORC1 Signaling
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