DSCR9 and VPS54

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	VPS54
Description		Down syndrome critical region 9	VPS54 subunit of GARP complex
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cellular_component	GARP Complex Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Trans-Golgi Network Cytosol Membrane Trans-Golgi Network Membrane Synapse Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function	Protein Binding Syntaxin Binding
	Biological Process	Biological_process	In Utero Embryonic Development Apoptotic DNA Fragmentation Protein Targeting To Lysosome Protein Targeting To Vacuole Intracellular Calcium Ion Homeostasis Golgi To Vacuole Transport Striated Muscle Contraction Mitochondrion Organization Vacuole Organization Lysosomal Transport Neuromuscular Synaptic Transmission Skeletal Muscle Tissue Development Intracellular Protein Localization Gene Expression Ubiquitin Recycling Microglia Differentiation Protein Transport Respiratory Electron Transport Chain Sphingolipid Catabolic Process Protein Localization To Cell Surface Limb Morphogenesis Post-embryonic Forelimb Morphogenesis Synaptic Transmission, Glutamatergic Regulation Of Growth Retrograde Transport, Endosome To Golgi Protein Targeting To ER Response To Antibiotic Spermatid Differentiation Skeletal Muscle Tissue Growth Astrocyte Differentiation Neuron Projection Morphogenesis Homeostasis Of Number Of Cells Homeostasis Of Number Of Cells Within A Tissue Musculoskeletal Movement Neuron Apoptotic Process Response To Calcium Ion Synaptic Transmission, GABAergic L-glutamate Import Neurofilament Cytoskeleton Organization Limb Development Motor Behavior Thrombin-activated Receptor Signaling Pathway Cellular Response To Progesterone Stimulus Vesicle-mediated Cholesterol Transport Motor Neuron Apoptotic Process Neural Tissue Regeneration Neuroinflammatory Response Negative Regulation Of Motor Neuron Apoptotic Process
Pathways			Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Clozapine-induced agranulocytosis ( 25187353) Diastolic blood pressure ( 30224653)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	6 interacting genes: DSCAM DSCR9 DYRK1A KLHL20 MOGS VPS51
Entrez ID		257203	51542
HPRD ID		10925	10302
Ensembl ID		ENSG00000230366	ENSG00000143952
Uniprot IDs			Q9P1Q0
PDB IDs
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Axon Dendrite Histone H3T45 Kinase Activity Glucosidase Activity Glc3Man9GlcNAc2 Oligosaccharide Glucosidase Activity Type II Interferon Binding Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Protein K33-linked Ubiquitination Cytosolic Transport GARP Complex Trans-Golgi Network EARP Complex Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Heterochromatin Formation Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding
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