DSCR9 and GNPTAB

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	GNPTAB
Description		Down syndrome critical region 9	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Molecular_function	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Calcium Ion Binding Protein Binding Transferase Activity Transferase Activity, Transferring Phosphorus-containing Groups Metal Ion Binding
	Biological Process	Biological_process	Lysosome Organization Protein Secretion Protein Transport N-glycan Processing To Lysosome Secretion Of Lysosomal Enzymes Carbohydrate Phosphorylation Establishment Of Localization In Cell
Pathways
Drugs
Diseases			Mucolipidosis II and III, including: Mucolipidosis II / I-cell disease; Mucolipidosis III A / Pseudo-Hurler polydystrophy; Mucolipidosis III C
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	10 interacting genes: AEN APP DISC1 DSCAM DSCR9 FAM90A1 MAPK1 PSMA1 STAMBPL1 ZNF250
Entrez ID		257203	79158
HPRD ID		10925	11350
Ensembl ID		ENSG00000230366	ENSG00000111670
Uniprot IDs			Q3T906
PDB IDs			2N6D 7S05 7S06 9BGF 9BGG
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Axon Positive Regulation Of Phosphate Metabolic Process Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Intracellular Monoatomic Cation Homeostasis Trans-synaptic Signaling Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Calcium Ion Regulation Of Developmental Growth Regulation Of Chemotaxis Cell Body Positive Regulation Of Chemotaxis Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Leukocyte Chemotaxis Neuron Recognition Regulation Of Inflammatory Response Lipoprotein Particle Synaptic Signaling Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Intracellular Monoatomic Ion Homeostasis Microglia Development Glial Cell Development Positive Regulation Of G Protein-coupled Receptor Internalization Synapse Post-embryonic Retina Morphogenesis In Camera-type Eye Netrin Receptor Binding Regulation Of Axon Extension Positive Regulation Of Axon Extension Positive Regulation Of Axonogenesis Cellular Response To Amino Acid Starvation Cytosine Metabolic Process Interleukin-34-mediated Signaling Pathway Response To Amino Acid Starvation Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone DNA Exonuclease Activity Positive Regulation Of Cellular Component Organization Monoatomic Ion Homeostasis Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
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