DSCR9 and USP33

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	USP33
Description		Down syndrome critical region 9	ubiquitin specific peptidase 33
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol Cytoskeleton Focal Adhesion VCB Complex Neuronal Cell Body Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function	G Protein-coupled Receptor Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Small GTPase Binding Ubiquitin Binding Metal Ion Binding
	Biological Process	Biological_process	Proteolysis Ubiquitin-dependent Protein Catabolic Process Endocytosis Nervous System Development Axon Guidance Regulation Of G Protein-coupled Receptor Signaling Pathway Cell Migration Protein Deubiquitination Protein Stabilization Centrosome Duplication Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of Autophagosome Assembly
Pathways			Ub-specific processing proteases Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Adult body size ( 32376654) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	18 interacting genes: CCP110 CHRM5 DDX56 DIO2 DSCR9 EIF6 ELOB ELOC PRKN SELENBP1 SNCA TRIM54 TRIM63 UBC USP15 USP21 USP28 VHL
Entrez ID		257203	23032
HPRD ID		10925	10297
Ensembl ID		ENSG00000230366	ENSG00000077254
Uniprot IDs			Q8TEY7
PDB IDs			2UZG
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	Post-translational Protein Modification Dopamine Transport Monoamine Transport Protein Deubiquitination Amyloid Fibril Formation Protein Modification By Small Protein Removal Target-directed MiRNA Degradation Elongin Complex Protein Modification Process Dopamine Uptake Involved In Synaptic Transmission Protein Ubiquitination Protein Metabolic Process Selenium Binding Protein Modification By Small Protein Conjugation Catecholamine Uptake Dopamine Uptake Regulation Of ATP Metabolic Process MiRNA Catabolic Process Phenol-containing Compound Metabolic Process Regulation Of Purine Nucleotide Metabolic Process Proteolysis Synaptic Transmission, Dopaminergic Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Cul5-RING Ubiquitin Ligase Complex Cysteine-type Deubiquitinase Activity Macromolecule Metabolic Process Cul2-RING Ubiquitin Ligase Complex Ubiquitin Ligase Complex Neurotransmitter Reuptake Regulation Of Neurotransmitter Uptake Regulation Of Dopamine Metabolic Process Phospholipase Binding Regulation Of Phosphorus Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Dopamine Secretion MiRNA Metabolic Process Regulation Of Small Molecule Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of MiRNA-mediated Gene Silencing Cysteine-type Peptidase Activity Deubiquitinase Activity Post-transcriptional Gene Silencing Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Post-transcriptional Gene Silencing Neurotransmitter Uptake Regulation Of Synaptic Vesicle Recycling Cytosol Dopamine Metabolic Process Regulation Of Protein Stability
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