FBH1 and RAD51

Number of citations of the paper that reports this interaction (PubMedID 25585578)
0

Data Source:
BioGRID (enzymatic study)

		FBH1	RAD51
Description		F-box DNA helicase 1	RAD51 recombinase
Image
GO Annotations	Cellular Component	Chromatin Nucleus Chromosome SCF Ubiquitin Ligase Complex	Nuclear Ubiquitin Ligase Complex Nuclear Chromosome Chromosome, Telomeric Region Chromatin Condensed Chromosome Condensed Nuclear Chromosome Lateral Element Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Mitochondrion Mitochondrial Matrix Centrosome Cytosol Cytoskeleton PML Body Protein-containing Complex Site Of Double-strand Break Perinuclear Region Of Cytoplasm Presynaptic Intermediate Filament Cytoskeleton
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Double-stranded DNA Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding DNA Translocase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity 3'-5' DNA Helicase Activity	DNA Strand Exchange Activity Nucleotide Binding DNA Binding Chromatin Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Single-stranded DNA Helicase Activity Enzyme Binding Identical Protein Binding DNA Polymerase Binding ATP-dependent DNA Damage Sensor Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Protein Phosphorylation DNA Repair DNA Catabolic Process DNA Damage Response Protein Ubiquitination Replication Fork Processing Response To Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Metabolic Process DNA Repair DNA Recombination Mitotic Recombination DNA Damage Response Meiosis I Reciprocal Meiotic Recombination Response To Xenobiotic Stimulus Response To Toxic Substance Response To X-ray Regulation Of Double-strand Break Repair Via Homologous Recombination Telomere Maintenance Via Telomere Lengthening Replication Fork Processing Telomere Organization Interstrand Cross-link Repair DNA Strand Invasion Meiotic Cell Cycle Chromosome Organization Involved In Meiotic Cell Cycle Cellular Response To Alkaloid Cellular Response To Ionizing Radiation Cellular Response To Gamma Radiation Cellular Response To Hydroxyurea Cellular Response To Cisplatin Cellular Response To Camptothecin Response To Glucoside Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Recombination-dependent Replication Fork Processing Double-strand Break Repair Involved In Meiotic Recombination Regulation Of DNA Damage Checkpoint
Pathways			HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Transcriptional Regulation by E2F6 Meiotic recombination Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs			Phosphoaminophosphonic Acid-Adenylate Ester Amuvatinib
Diseases
GWAS			Anxiety and stress-related disorders ( 31116379) Hip circumference adjusted for BMI ( 34021172) Malaria ( 31844061) Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278)
Interacting Genes		12 interacting genes: CUL1 DSCR9 ESR1 PCNA PIM2 RAD51 RBX1 RNF20 RPL13A SKP1 UBC ZDHHC17	100 interacting genes: ABL1 AGO2 ATM ATRX BARD1 BCCIP BCR BLM BRCA1 BRCA2 CASP3 CASP7 CASP8AP2 CCND1 CDH13 CHD3 CHEK1 CRYAA CSNK2A1 CSNK2B CST6 CTCF DDB2 DMC1 DNAJA3 DYRK1A ENAH EP400 ERCC2 ERCC5 EVL FANCD2 FANCI FBH1 FBXO5 FIRRM GMEB1 HID1 HNRNPC HSP90AA1 IL24 IRS1 ITIH5 MAPK8IP3 MCPH1 MDC1 MMS22L MSH4 NBN NCL NELFB NXF1 PARPBP PCSK1N PDS5B PFN1 PIAS1 PLK1 POLA1 RAD18 RAD51AP1 RAD51AP2 RAD51C RAD52 RAD54B RAD54L RAD54L2 RECQL5 RELA RFWD3 RNF20 RPA1 RPA2 RPA3 SEM1 SFR1 SIRT2 ST14 SUMO1 SUMO2 SWSAP1 TDG TFF1 TOPORS TP53 TP53BP1 UBE2I UCHL3 UGDH UHRF2 UMPS USP10 VASP VIM WDR48 WRN XPO1 XRCC2 XRCC3 ZDHHC17
Entrez ID		84893	5888
HPRD ID		06243	01557
Ensembl ID		ENSG00000134452	ENSG00000051180
Uniprot IDs		B3KV95 F6UZG9 Q2TAK1 Q8NFZ0	Q06609
PDB IDs		8F5Q	1B22 1N0W 5H1B 5H1C 5JZC 5NP7 5NWL 7C9A 7EJC 7EJE 8BQ2 8BR2 8BSC 8GYK 8JND 8JNE 8JNF 8PBC 8PBD 8R64 8RCD 8RCF 8XBT 8XBU 8XBV 8XBW 8XBX 8XBY
Enriched GO Terms of Interacting Partners?		Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Epithelial Cell Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Cul7-RING Ubiquitin Ligase Complex Macromolecule Metabolic Process Protein Monoubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process SCF Ubiquitin Ligase Complex Ubiquitin Ligase Complex Scaffold Activity Positive Regulation Of Canonical NF-kappaB Signal Transduction Modification-dependent Protein Catabolic Process Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Protein Modification Process Protein Ubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Protein Ligase Binding Cullin-RING Ubiquitin Ligase Complex Protein K48-linked Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation DNA Polymerase Binding Cullin Family Protein Binding Mitotic Cell Cycle Phase Transition Post-translational Protein Modification Cell Cycle Phase Transition Protein Metabolic Process Cellular Response To Radiation Positive Regulation Of Autophagy Regulation Of Programmed Cell Death Chromatin Binding Nuclear Estrogen Receptor Binding Replication Fork Processing Cellular Response To Oxidative Stress Macromolecule Catabolic Process Ubiquitin-dependent Protein Catabolic Process Male Germ Cell Nucleus PCNA Complex Replisome Response To Glucoside Perforant Pathway To Dendrate Granule Cell Synapse Negative Regulation Of Formation Of Translation Preinitiation Complex Histone H2B C-terminal K Residue Ubiquitin Ligase Activity Cellular Response To Chemical Stress Proteolysis Lysosome Organization TORC1 Signaling Negative Regulation Of TORC1 Signaling Catabolic Process	DNA Repair DNA Damage Response DNA Metabolic Process Double-strand Break Repair Via Homologous Recombination Double-strand Break Repair Recombinational Repair Cellular Response To Stress DNA Recombination Nucleoplasm Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process Response To Stress Macromolecule Metabolic Process Nucleus PML Body Signal Transduction In Response To DNA Damage Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Regulation Of DNA Recombination Replication Fork Regulation Of Cell Cycle Single-stranded DNA Binding Response To Ionizing Radiation DNA Binding DNA Damage Checkpoint Signaling Response To Radiation Regulation Of DNA Repair Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Process Regulation Of Double-strand Break Repair Chromosome Organization Mitotic DNA Integrity Checkpoint Signaling Chromosome Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Damaged DNA Binding Negative Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cellular Response To Stress Negative Regulation Of Cell Cycle Process Site Of Double-strand Break Homologous Recombination Negative Regulation Of DNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Primary Metabolic Process Negative Regulation Of DNA Recombination
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