DSCR9 and GAR1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		DSCR9	GAR1
Description		Down syndrome critical region 9	GAR1 ribonucleoprotein
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component	Chromosome, Telomeric Region Fibrillar Center Nucleus Nucleoplasm Telomerase Holoenzyme Complex Nucleolus Cajal Body Box H/ACA SnoRNP Complex Box H/ACA ScaRNP Complex Box H/ACA Telomerase RNP Complex Ribonucleoprotein Complex
	Molecular Function	Molecular_function	RNA Binding Protein Binding Box H/ACA SnoRNA Binding Telomerase RNA Binding
	Biological Process	Biological_process	SnoRNA Guided RRNA Pseudouridine Synthesis Pseudouridine Synthesis RRNA Processing Telomere Maintenance Via Telomerase Ribosome Biogenesis
Pathways			Telomere Extension By Telomerase rRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Eye color traits ( 20463881) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)
Interacting Genes		146 interacting genes: ACTB ACTN4 ACTR3B ADAMTS8 ADGRB3 AKAP8L ALDOA APP ASB3 ASH1L ATXN10 BEX3 BFSP1 BICD2 BTBD1 CCDC6 CD74 CELSR3 CERCAM CIAO3 CLTC CLU CNKSR1 CNOT2 COPB1 COPS4 CREBZF CTSB CXXC5 DARS1 DCAF6 DDX3X DIS3L DNAJA1 DPYSL2 DST DYNC1H1 EFEMP1 EXTL3 EYA3 FAN1 FBH1 FBXL16 FBXO11 FN1 FN3K FUZ GAR1 GIT1 GNPTAB GPRASP2 GUCY1B1 HDAC6 HNRNPK HPF1 HPS4 IFT122 IMMT ITCH JAKMIP1 KALRN KDM5A KIF1A KIF3A KLHL7 LMO7 LONRF1 LRP4 MACF1 MCRS1 METTL8 MIPOL1 MORF4L1 MTMR3 MTUS2 MYCBP2 NAGK NARS1 NBEA NCBP1 NDUFA10 NDUFB7 NEUROD6 NFE2L3 NIPBL NR4A2 OLR1 P4HTM PAK1 PAK2 PBXIP1 PCCB PDCD7 PDE4DIP PICK1 PIK3R4 PLEKHB1 PLXNB3 PPP4R1 PRKAR1A PSMC1 PSMD2 QRICH1 RAP1GAP RNF10 RSBN1L SBNO1 SEC23IP SESN3 SGSM2 SMPD3 SMURF2 SNX5 SPARCL1 SPOCK2 SPRED1 SPRY2 SPTBN1 STAMBP STX1A SULF1 SYNE1 TARS1 TNKS2 TPP1 TRIM5 TRIO TRIOBP TRIP12 TSG101 TTYH1 USP33 USP47 USP8 VARS1 VPS54 VPS9D1 WDR13 WDR26 WDR47 WRAP53 XAB2 XRN2 ZNF528 ZNFX1 ZRSR2	8 interacting genes: DSCR9 FOXP1 LARP7 NEAT1 PCBP2 SMN1 SMN2 UBC
Entrez ID		257203	54433
HPRD ID		10925	07569
Ensembl ID		ENSG00000230366	ENSG00000109534
Uniprot IDs			Q9NY12
PDB IDs			7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		Cytoplasm Cytoskeleton Macromolecule Metabolic Process Cytosol Protein Metabolic Process Post-translational Protein Modification Protein Modification Process Intracellular Protein Localization Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Small GTPase Binding Cytoskeleton-dependent Intracellular Transport Identical Protein Binding Regulation Of Signal Transduction Vesicle-mediated Transport Neuron Projection Morphogenesis Transport Along Microtubule Regulation Of Wnt Signaling Pathway Protein Modification By Small Protein Conjugation Cell Projection Morphogenesis Positive Regulation Of Cellular Component Organization Positive Regulation Of Microtubule Nucleation Regulation Of Cellular Component Organization Microtubule Negative Regulation Of Signal Transduction Organelle Organization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Organelle Organization Catabolic Process Low-density Lipoprotein Particle Receptor Binding Axo-dendritic Transport Macromolecule Catabolic Process Protein Ubiquitination Regulation Of Microtubule Cytoskeleton Organization Regulation Of Signaling Microtubule-based Transport Regulation Of Supramolecular Fiber Organization Regulation Of Intracellular Signal Transduction Centrosome Nucleus Intracellular Transport Cellular Localization Axon Cytoplasm Regulation Of Cellular Response To Stress Regulation Of Cell Communication Establishment Of Protein Localization To Vacuole Platelet Alpha Granule Lumen Establishment Of Localization In Cell Regulation Of Intrinsic Apoptotic Signaling Pathway	SMN Complex Gemini Of Cajal Bodies SMN-Sm Protein Complex DNA-templated Transcription Termination MRNA Metabolic Process Spliceosomal SnRNP Assembly Spliceosomal Complex Assembly RNA Binding Cajal Body RNA Splicing U6 2'-O-snRNA Methylation Cytoplasmic Ribonucleoprotein Granule MRNA Processing Positive Regulation Of Interleukin-21 Production Box C/D Sno(s)RNA 3'-end Processing MiRNA Inhibitor Activity Via Base-pairing RNA Metabolic Process Perikaryon Z Disc Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of SnRNA Transcription By RNA Polymerase II 7SK SnRNP RISC Complex Binding Positive Regulation Of Synoviocyte Proliferation LncRNA-mediated Post-transcriptional Gene Silencing Nucleoplasm Promoter-enhancer Loop Anchoring Activity Regulation Of Macrophage Colony-stimulating Factor Production SnRNA Modification Positive Regulation Of MiRNA Catabolic Process Viral RNA Genome Replication Osteoclast Development Regulation Of Endothelial Tube Morphogenesis Protein-RNA Complex Assembly Positive Regulation Of B Cell Receptor Signaling Pathway RNA Splicing, Via Transesterification Reactions Monocyte Activation Endothelial Cell Activation 7SK SnRNA Binding Positive Regulation Of Protein Localization To Cajal Body Paraspeckles Regulation Of MRNA Export From Nucleus IRES-dependent Viral Translational Initiation T Follicular Helper Cell Differentiation Regulation Of Defense Response RNA Processing Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development U6 SnRNA Binding Negative Regulation Of B Cell Apoptotic Process
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