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DSCR9 and PSMC1
Number of citations of the paper that reports this interaction (PubMedID
35914814
)
83
Data Source:
BioGRID
(two hybrid)
DSCR9
PSMC1
Description
Down syndrome critical region 9
proteasome 26S subunit, ATPase 1
Image
No pdb structure
GO Annotations
Cellular Component
Cellular_component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Regulatory Particle
Proteasome Regulatory Particle, Base Subcomplex
Membrane
Proteasome Accessory Complex
Molecular Function
Molecular_function
Nucleotide Binding
RNA Binding
Protein Binding
ATP Binding
ATP Hydrolysis Activity
Proteasome-activating Activity
Biological Process
Biological_process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Protein Catabolic Process
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
Assembly of the pre-replicative complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
KEAP1-NFE2L2 pathway
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Degradation of CDH1
Somitogenesis
Antigen processing: Ubiquitination & Proteasome degradation
Proteasome assembly
Proteasome assembly
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
SPOP-mediated proteasomal degradation of PD-L1(CD274)
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
Degradation of CRY and PER proteins
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
Drugs
Diseases
GWAS
Eye color traits (
20463881
)
Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction (
34099189
)
Response to platinum-based neoadjuvant chemotherapy in cervical cancer (
28120872
)
Seasonality and depression (
30217971
)
Interacting Genes
146 interacting genes:
ACTB
ACTN4
ACTR3B
ADAMTS8
ADGRB3
AKAP8L
ALDOA
APP
ASB3
ASH1L
ATXN10
BEX3
BFSP1
BICD2
BTBD1
CCDC6
CD74
CELSR3
CERCAM
CIAO3
CLTC
CLU
CNKSR1
CNOT2
COPB1
COPS4
CREBZF
CTSB
CXXC5
DARS1
DCAF6
DDX3X
DIS3L
DNAJA1
DPYSL2
DST
DYNC1H1
EFEMP1
EXTL3
EYA3
FAN1
FBH1
FBXL16
FBXO11
FN1
FN3K
FUZ
GAR1
GIT1
GNPTAB
GPRASP2
GUCY1B1
HDAC6
HNRNPK
HPF1
HPS4
IFT122
IMMT
ITCH
JAKMIP1
KALRN
KDM5A
KIF1A
KIF3A
KLHL7
LMO7
LONRF1
LRP4
MACF1
MCRS1
METTL8
MIPOL1
MORF4L1
MTMR3
MTUS2
MYCBP2
NAGK
NARS1
NBEA
NCBP1
NDUFA10
NDUFB7
NEUROD6
NFE2L3
NIPBL
NR4A2
OLR1
P4HTM
PAK1
PAK2
PBXIP1
PCCB
PDCD7
PDE4DIP
PICK1
PIK3R4
PLEKHB1
PLXNB3
PPP4R1
PRKAR1A
PSMC1
PSMD2
QRICH1
RAP1GAP
RNF10
RSBN1L
SBNO1
SEC23IP
SESN3
SGSM2
SMPD3
SMURF2
SNX5
SPARCL1
SPOCK2
SPRED1
SPRY2
SPTBN1
STAMBP
STX1A
SULF1
SYNE1
TARS1
TNKS2
TPP1
TRIM5
TRIO
TRIOBP
TRIP12
TSG101
TTYH1
USP33
USP47
USP8
VARS1
VPS54
VPS9D1
WDR13
WDR26
WDR47
WRAP53
XAB2
XRN2
ZNF528
ZNFX1
ZRSR2
40 interacting genes:
APP
ATXN7
CCDC85B
CCND3
CEBPA
CNOT7
CRK
DSCR9
FBLN5
FKBP8
HSPB1
JMJD1C
JMJD6
KDM1A
LINC01554
LNX1
MAGEA2
MAGEA2B
MEOX2
MORF4L1
OGT
PAAF1
PAX4
PIAS3
PRKN
PSMA7
PSMC2
PSMD2
PSMD5
PSMD7
PTGER4
STMN2
SUMO2
SUV39H1
TRAF6
UBASH3A
UBLCP1
VCP
VHL
ZBTB8A
Entrez ID
257203
5700
HPRD ID
10925
04084
Ensembl ID
ENSG00000230366
ENSG00000100764
Uniprot IDs
P62191
Q53XL8
PDB IDs
5GJQ
5GJR
5L4G
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
5VGZ
5VHF
5VHH
5VHI
5VHJ
5VHM
5VHN
5VHO
5VHP
5VHQ
5VHR
5VHS
6MSB
6MSD
6MSG
6MSH
6MSJ
6MSK
6WJD
6WJN
7QXN
7QXP
7QXU
7QXW
7QXX
7QY7
7QYA
7QYB
7W37
7W38
7W39
7W3A
7W3B
7W3C
7W3F
7W3G
7W3H
7W3I
7W3J
7W3K
7W3M
8CVT
8JRI
8JRT
8JTI
8K0G
8USB
8USC
8USD
9E8G
9E8H
9E8I
9E8J
9E8K
9E8L
9E8N
9E8O
9E8Q
Enriched GO Terms of Interacting Partners
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Cytoplasm
Cytoskeleton
Macromolecule Metabolic Process
Cytosol
Protein Metabolic Process
Post-translational Protein Modification
Protein Modification Process
Intracellular Protein Localization
Positive Regulation Of Wnt Signaling Pathway
Positive Regulation Of Amyloid Fibril Formation
Small GTPase Binding
Cytoskeleton-dependent Intracellular Transport
Identical Protein Binding
Regulation Of Signal Transduction
Vesicle-mediated Transport
Neuron Projection Morphogenesis
Transport Along Microtubule
Regulation Of Wnt Signaling Pathway
Protein Modification By Small Protein Conjugation
Cell Projection Morphogenesis
Positive Regulation Of Cellular Component Organization
Positive Regulation Of Microtubule Nucleation
Regulation Of Cellular Component Organization
Microtubule
Negative Regulation Of Signal Transduction
Organelle Organization
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Organelle Organization
Catabolic Process
Low-density Lipoprotein Particle Receptor Binding
Axo-dendritic Transport
Macromolecule Catabolic Process
Protein Ubiquitination
Regulation Of Microtubule Cytoskeleton Organization
Regulation Of Signaling
Microtubule-based Transport
Regulation Of Supramolecular Fiber Organization
Regulation Of Intracellular Signal Transduction
Centrosome
Nucleus
Intracellular Transport
Cellular Localization
Axon Cytoplasm
Regulation Of Cellular Response To Stress
Regulation Of Cell Communication
Establishment Of Protein Localization To Vacuole
Platelet Alpha Granule Lumen
Establishment Of Localization In Cell
Regulation Of Intrinsic Apoptotic Signaling Pathway
Proteasome Complex
Regulation Of Transcription By RNA Polymerase II
Regulation Of DNA-templated Transcription
Regulation Of Macromolecule Metabolic Process
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Post-translational Protein Modification
Regulation Of Gene Expression
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Regulation Of Metabolic Process
Regulation Of Post-translational Protein Modification
Regulation Of Protein Metabolic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Protein Modification Process
Positive Regulation Of Protein Metabolic Process
Nucleus
Positive Regulation Of Proteolysis
Positive Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Protein Sumoylation
Regulation Of Protein Catabolic Process
Proteasome Regulatory Particle, Base Subcomplex
Negative Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Factor Binding
Negative Regulation Of Biosynthetic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Ubiquitination
Positive Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Proteasomal Protein Catabolic Process
Proteasome Accessory Complex
Positive Regulation Of Protein Catabolic Process
Protein Catabolic Process
Histone Deacetylase Binding
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Catabolic Process
Regulation Of Protein Sumoylation
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of Protein Modification Process
Regulation Of Proteolysis
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